A5076664078- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Electrospun Nanofibers in Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Artery Disease Management
- Tissue Engineering and Regenerative Medicine
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Cardiac Health and Mental Health
- Mesenchymal stem cell research
- Cardiac, Anesthesia and Surgical Outcomes
- Blood Pressure and Hypertension Studies
- Ultrasound in Clinical Applications
Carmel Medical Center
2014-2024
Technion – Israel Institute of Technology
2011-2024
Clalit Health Services
2018
Pluristem Therapeutics (Israel)
2017-2018
University of Pennsylvania
2012-2016
National Heart Lung and Blood Institute
1992-2015
National Institutes of Health
2015
Children's National
2015
Boğaziçi University
2015
University of Michigan
2012
Background— Multidetector computed tomography (MDCT) has high diagnostic value for detecting or excluding coronary artery stenosis. We examined performance characteristics of MDCT diagnosing an acute syndrome in patients presenting to the emergency department (ED) with possible ischemic chest pain and relation clinical outcome during a 15-month follow-up period. Methods Results— prospectively studied 58 (56±10 years age, 36% female) possibly origin no new ECG changes elevated biomarkers. The...
Background: Periodontitis is associated with increased prevalence of cardiovascular morbidity and mortality; however, the nature this association unclear. There a rationale that indicates presence periodontal pockets which can harbor pathogenic microorganisms evoke host response could elicit systemic effect. The hypothesis study may be elevated blood lipid levels, known risk factor for atherosclerotic disease. Methods: health 10,590 Israeli military service men women was assessed using...
Heparanase is a heparan sulfate degrading endoglycosidase participating in extracellular matrix degradation and remodeling. synthesized as 65 kDa non-active precursor that subsequently undergoes proteolytic cleavage, yielding 8 50 protein subunits heterodimerize to form an active enzyme. The protease responsible for heparanase processing currently unknown, the sub-cellular site. In this study, we characterize antibody (733) preferentially recognizes compared precursor. We have utilized other...
Heparanase is a mammalian endoglycosidase that degrades heparan sulfate (HS) at specific intrachain sites, an activity strongly implicated in cell dissemination associated with metastasis and inflammation. In addition to its structural role extracellular matrix assembly integrity, HS sequesters multitude of polypeptides reside the as reservoir. A variety growth factors, cytokines, chemokines, enzymes can be released by heparanase profoundly affect tissue function. Thus, bioavailability,...
We evaluated the extent to which anatomic barriers vector penetration might influence distribution of successful in vivo gene transfer into normal arterial wall. A double-balloon catheter technique with infusion pressures 100 400 mm Hg was used infuse microscopic tracer particles size range liposomes and viral vectors elastic arteries sheep. Localization tissue sections by light, fluorescence, electron microscopy suggested that vector-sized were delivered intima direct adventitia via vasa...
Intravascular stents, currently in experimental human use for recurrent arterial stenosis, are plagued by subacute thrombosis. As a therapeutic approach to stent-related thrombosis, we and others have suggested coating stents with endothelial cells before implantation. In previous study demonstrated the feasibility of that were genetically modified secrete large amounts tissue plasminogen activator. present attempted both develop clinically applicable protocol stent seeding test whether...
In vitro prevascularization of engineered tissue constructs promises to enhance their clinical applicability. We hypothesize that adult endothelial cells (ECs), isolated from limb veins elderly patients, bear the vasculogenic properties required form vascular networks in can later integrate with host vasculature upon implantation. Here, we show ECs formed vessel were more developed and complex than those by human umbilical vein (HUVECs) seeded various supporting on three-dimensional (3D)...
Engineered tissues are a promising tool for addressing the growing need and organs in surgical reconstructions. Prevascularization of implanted is expected to enhance survival prospects post transplantation minimize deficiencies and/or hypoxia deeper tissue. Here, we fabricate three-dimensional, prevascularized engineered muscle containing human myoblasts, genetically modified endothelial cells secreting angiopoietin 1 (ANGPT1) smooth vascular growth factor (VEGF). The shows enhanced host...
Autonomic control of the cardiovascular system may be impaired in type 2 diabetes and is associated with increased morbidity mortality. Parameters obtained during stress testing reflect early stages cardiac autonomic dysfunction provide prognostic information asymptomatic diabetes. We performed maximal exercise treadmill 594 patients without known coronary heart disease. The significance physiological parameters was assessed, including chronotropic incompetence (<80% rate reserve), abnormal...
The hemodynamic effects of cardiac pacing at different rates and in modes were studied 21 patients who candidates for permanent pacemaker implantation. Nine these had primary conduction disturbances (PCD), ten ischemic heart disease (IHD), seven with additional failure (CHF), two hypertrophic cardiomyopathy (HCM). In PCD, atrial (AOO) AV sequential (DVI) did not change systolic blood pressure pulse but ventricular (VVI) caused a progressive fall measurements, especially as rate increased....
Type 2 diabetics are at increased risk for vascular events, but the value of further stratification coronary heart disease (CHD) in asymptomatic subjects is unclear. We examined added computed tomography angiography over clinical scores (United Kingdom Prospective Diabetes Study), and artery calcium a population-based cohort type diabetics.Subjects (n=630) underwent baseline assessment (64-slice scanner). Plaque site, volume, calcific content, arterial remodeling were recorded using...
Coronary artery disease often progresses more rapidly in diabetics, but the integrated impact of diabetes and early revascularization status on late or repeat contemporary era is less clear.Coronary angiography was performed 12,420 patients between years 2000-2015 [none, percutaneous coronary intervention (PCI) bypass surgery (CABG)] determined. Subsequent procedures were recorded over a median follow-up 67 months its relation to diabetic baseline studied.Early none 5391, PCI 5682 CABG 1347...