A5051590202- Gestational Diabetes Research and Management
- Pancreatic function and diabetes
- Diabetes Management and Research
- Pregnancy and preeclampsia studies
- Bariatric Surgery and Outcomes
- Diabetes and associated disorders
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Liver Disease Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Glaucoma and retinal disorders
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Mobile Health and mHealth Applications
- Climate Change and Health Impacts
- Maternal Mental Health During Pregnancy and Postpartum
- Advanced Chemical Sensor Technologies
- Diabetes Treatment and Management
- Cinema and Media Studies
- Breastfeeding Practices and Influences
- Food Security and Health in Diverse Populations
Australian National University
2016-2025
Canberra Hospital
2016-2025
Act Health
2017-2024
ACT Government
2009-2024
Camden and Campbelltown Hospitals
2024
Government of the Northern Territory
2024
IP Australia
2024
University of Asia Pacific
2024
Madras Diabetes Research Foundation
2023
Bankstown Lidcombe Hospital
2023
We have proposed the “glucolipotoxicity” hypothesis in which elevated free fatty acids (FFAs) together with hyperglycemia are synergistic causing islet β-cell damage because high glucose inhibits fat oxidation and consequently lipid detoxification. The effects of 1–2 d culture both rat INS 832/13 cells human β-cells were investigated medium containing (5, 11, 20 mm) presence or absence various FFAs. A marked effect concentrations saturated FFA (palmitate stearate) on inducing death by...
Whether treatment of gestational diabetes before 20 weeks' gestation improves maternal and infant health is unclear. Download a PDF the Research Summary. We randomly assigned, in 1:1 ratio, women between 4 19 weeks 6 days' who had risk factor for hyperglycemia diagnosis (World Health Organization 2013 criteria) to receive immediate or deferred no treatment, depending on results repeat oral glucose-tolerance test [OGTT] at 24 28 (control). The trial included three primary outcomes: composite...
Abstract Diabetic ketoacidosis (DKA) is a life‐threatening acute complication of diabetes characterized by the accumulation ketone bodies in blood. Breath acetone, ketone, directly correlates with blood ketones. Therefore, monitoring breath acetone can significantly enhance safety and efficacy care. In this work, design fabrication an InP/Pt/chitosan nanowire array‐based chemiresistive sensor reported. By incorporation chitosan as surface‐functional layer Pt Schottky contact for efficient...
The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin secretion (GIIS) predicts that malonyl-CoA derived from glucose metabolism inhibits fatty acid oxidation, thereby increasing the availability LC-CoA for lipid signaling to cellular processes involved in exocytosis. For directly testing model, INSr3 cell clones overexpressing decarboxylase cytosol (MCDc) a tetracycline regulatable manner were generated, and INS(832/13) rat islets infected with MCDc-expressing...
Abstract Aims/hypothesis Pancreatic beta cell dedifferentiation, transdifferentiation into other islet cells and apoptosis have been implicated in failure type 2 diabetes, although the mechanisms are poorly defined. The endoplasmic reticulum stress response factor X-box binding protein 1 (XBP1) is a major regulator of unfolded response. XBP1 expression reduced islets people with but its role adult differentiated unclear. Here, we assessed effects Xbp1 deletion tested whether XBP1-mediated...
In most gestational diabetes mellitus (GDM) studies, cohorts have included women combined into study populations without regard to whether hyperglycemia was present earlier in pregnancy. this we sought compare perinatal outcomes between groups: with early GDM (EGDM group: diagnosis before 20 weeks' gestation but no treatment until 24-28 if still present), late (LGDM only at gestation), and normoglycemia (control participants).
BackgroundA recently undertaken multicenter randomized controlled trial (RCT) "Treatment Of BOoking Gestational diabetes Mellitus" (TOBOGM: 2017–2022) found that the diagnosis and treatment of pregnant women with early gestational mellitus (GDM) improved pregnancy outcomes. Based on data from trial, this study aimed to assess cost-effectiveness GDM (from <20 weeks') among risk factors for hyperglycemia in compared usual care (no until 24–28 a healthcare perspective.MethodsParticipants'...
OBJECTIVE To compare pregnancy outcomes among women with a normal oral glucose tolerance test (OGTT) before 20 weeks’ gestation (early) and at 24–28 (late) (no gestational diabetes mellitus, or No-GDM), those early GDM randomized to observation subsequent OGTT (GDM-Regression), on both occasions (GDM-Maintained). RESEARCH DESIGN AND METHODS Women &lt;20 risk factors who were recruited for controlled treatment trial included. treated late (according the World Health Organization’s 2013...
In 47 patients with diabetic nephropathy (29 type I, 18 II) renal function and blood pressure (BP) (treated or without an angiotensin-converting enzyme [ACE] inhibitor, enalapril [10 mg], in 38 hypertensive patients) were followed over 4 years. A percutaneous biopsy was performed all initially repeated a representative 19 treated hypertension after Mean glomerular volume (MGV), interstitial fibrosis (IF), capillary volume, sclerosed glomeruli (GS) measured histomorphometrically. fall...
The authors investigated 50 Yersinia enterocolitica infections during an outbreak of illness due to contaminated tofu (soybean curd) in Washington State between December 15, 1981 and February 22, 1982. most common clinical syndrome (36 patients) was gastrointestinal infection for which two patients underwent appendectomies one a partial colectomy. Of the remaining 14 patients, six had extraintestinal infections, fever alone, were asymptomatic. with enteric younger (median age three years)...