A5026893546- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Cardiovascular and exercise physiology
- Cellular Mechanics and Interactions
- Computational Drug Discovery Methods
- Cardiac Valve Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Mitochondrial Function and Pathology
- Muscle activation and electromyography studies
- Hippo pathway signaling and YAP/TAZ
- Transcranial Magnetic Stimulation Studies
- Heart Rate Variability and Autonomic Control
- Neurosurgical Procedures and Complications
- Autophagy in Disease and Therapy
- Prostate Cancer Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Free Radicals and Antioxidants
- Takotsubo Cardiomyopathy and Associated Phenomena
- ATP Synthase and ATPases Research
- Blood Pressure and Hypertension Studies
- Epigenetics and DNA Methylation
- Nanoparticle-Based Drug Delivery
- Cardiac Imaging and Diagnostics
- Stroke Rehabilitation and Recovery
- Cancer, Hypoxia, and Metabolism
Masaryk University
2021-2024
St. Anne's University Hospital Brno
2019-2023
University Hospital Brno
2019-2023
The mechanoregulated proteins YAP/TAZ are involved in the adipogenic/osteogenic switch of mesenchymal stem cells (MSCs). MSC fate decision can be unbalanced by controlling substrate mechanics, turn altering transmission tension through cell cytoskeleton. MSCs have been proposed for orthopedic and reconstructive surgery applications. Thus, a tight control their adipogenic potential is required order to avoid drifting towards fat tissue. Substrate mechanics has shown drive commitment regulate...
Nanodrugs represent novel solutions to reshuffle repurposed drugs for cancer therapy. They might offer different therapeutic options by combining targeted drug delivery and imaging in unique platforms. Such nanomaterials are deemed overcome the limitations of currently available treatments, ultimately improving patients’ life quality. However, despite these promises being made over three decades, poor clinical translation nanoparticle- based therapies calls deeper vitro vivo investigations....
Aim. Specify the risk rate of incorrect patient classification based on night-to-day ratio specification from singular 24-h ABPM in comparison to results 7-day monitoring Materials and Methods. 1197 24 h cycles were enrolled 171 subjects study divided into 4 groups: group 1 (40 healthy men women without exercise), 2 exercise-training women), 3 patients with ischemic coronary artery disease (51 following cardiovascular rehabilitation). The subject evaluation was percentage (dipper, nondipper,...
BACKGROUND Takotsubo cardiomyopathy (TTC) is a cardiac syndrome characterized by transient left ventricle (LV) dysfunction, typically showing apical ballooning due to akinesis with preserved basal segment contractility. The inverted form very uncommon and hypokinesis or normal LV CASE REPORT We describe the case of 49-year-old woman who developed TTC after orthotopic liver transplantation. On day 1 (D1), dyspnea oliguria suddenly appeared. A chest X-ray showed pulmonary edema,...
Abstract Extracellular matrix (ECM) tumorigenic alterations resulting in high deposition and stiffening are hallmarks of adenocarcinomas collectively defined as desmoplasia . Here, we thoroughly analysed primary prostate cancer tissues obtained from numerous patients undergoing radical prostatectomy to highlight reproducible structural changes the ECM leading loss glandular architecture. Starting patient cells, established tumoroids (PCTs) demonstrated they require TGF-β signalling pathway...
OBJECTIVES: Cisplatin is a widely used anticancer drug for the treatment of many solid cancers.DNA damage thought to be key mechanism cisplatin's activity.However, cisplatin may also affect cellular metabolism.The aim this study was determine effect on types ATP production (OXPHOS versus glycolysis) and their rate in prostate cancer cells potentially protective autophagy amino acids during treatment.We wanted investigate potential synergy between metabolic effects inhibition...