A5036536225- Force Microscopy Techniques and Applications
- Trace Elements in Health
- Education, Psychology, and Social Research
- Cellular Mechanics and Interactions
- Chemotherapy-induced organ toxicity mitigation
- Autophagy in Disease and Therapy
- Dendrimers and Hyperbranched Polymers
- Polymer Surface Interaction Studies
- Heavy Metal Exposure and Toxicity
- Molecular Biology Techniques and Applications
- Chromium effects and bioremediation
- Metabolomics and Mass Spectrometry Studies
- Bone Metabolism and Diseases
- Nigella sativa pharmacological applications
- Taxation and Legal Issues
- Spectroscopy Techniques in Biomedical and Chemical Research
- Proteoglycans and glycosaminoglycans research
- Operations Management Techniques
- Orthopedic Infections and Treatments
- Geological Formations and Processes Exploration
- Space Exploration and Technology
- Iron Metabolism and Disorders
- Biological Activity of Diterpenoids and Biflavonoids
- Radiopharmaceutical Chemistry and Applications
- Extracellular vesicles in disease
Masaryk University
2017-2024
Central European Institute of Technology
2017
Brno University of Technology
2017
We focused on the biomechanical and morphological characteristics of prostate cancer cells their changes resulting from effect docetaxel, cisplatin, long-term zinc supplementation. Cell population surviving treatment was characterized as follows: cell stiffness assessed by atomic force microscopy, motility invasion capacity were determined colony forming assay, wound healing coherence-controlled holographic real-time analysis. Cells metastatic origin exhibited lower height than derived...
Abstract Prostate cancer is the most commonly diagnosed tumor disease in men, and its treatment still a big challenge standard oncology therapy. Magnetically actuated microrobots represent promising technology modern nanomedicine, offering advantage of wireless guidance, effective cell penetration, non‐invasive actuation. Here, new biodegradable magnetically zinc/cystine‐based for situ prostate cells are reported. The fabricated via metal‐ion‐mediated self‐assembly amino acid cystine...
Abstract Extracellular vesicles (EVs) are important mediators of intercellular communication in the tumour microenvironment. Many studies suggest that cancer cells release higher amounts EVs exposing phosphatidylserine (PS) at surface. There lots interconnections between biogenesis and autophagy machinery. Modulation can probably affect not only quantity but also their content, which deeply influence resulting pro-tumourigenic or anticancer effect modulators. In this study, we found...
BACKGROUND Failure in intracellular zinc accumulation is a key process prostate carcinogenesis. Nevertheless, epidemiological studies of administration have provided contradicting results. In order to examine the impact artificial increase zinc(II) ions on cancer metabolism, PNT1A, 22Rv1, and PC-3 prostatic cell lines—depicting different stages progression—and their zinc-resistant counterparts were used. To determine "benign" "malignant" metabolic profiles, amino acid patterns, gene...
Abstract Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels heavy metals and their binding proteins can contribute Antiradical capacity levels metallothionein (MT), (zinc copper), selected antioxidants (bilirubin, cysteine, glutathione) were determined 70 type 2 diabetes mellitus (T2DM) subjects 80 healthy Caucasian origin. Single nucleotide polymorphism...
// Marketa Svobodova 1, 2, 3 , Martina Raudenska Jaromir Gumulec Jan Balvan 1 Michaela Fojtu Monika Kratochvilova Hana Polanska Zuzana Horakova 4 Rom Kostrica Petr Babula Zbynek Heger 3, 5 and Michal Masarik 2 Department of Physiology, Faculty Medicine, Masaryk University, CZ-62500 Brno, Czech Republic Pathological Central European Institute Technology, Brno University CZ-61600 Otorhinolaryngology Head Neck Surgery, St. Anne's Hospital, CZ-65691 Chemistry Biochemistry, Mendel in CZ-61300...
The main dose-limiting side effect of cisplatin is nephrotoxicity. utilization an issue balancing tumour toxicity versus platinum-induced In this study, we focused on intraorgan distribution common essential trace elements zinc, copper, and iron in healthy mouse kidneys platinum after treatment. Renal 12 nontreated Nu-Nu mice (males) was assessed by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Furthermore, 9 were treated with cisplatin. order concentration as...
The failure of intracellular zinc accumulation is a key process in prostate carcinogenesis. Although cancer cells can accumulate after long-term exposure, chronic oversupply may accelerate carcinogenesis or chemoresistance. Because progression associated with energetically demanding cytoskeletal rearrangements, we investigated the effect presence on biophysical parameters, ATP production, and EMT characteristics two cell lines (PC-3, 22Rv1). Prolonged exposure to increased spare respiratory...
OBJECTIVES: Cisplatin is a widely used anticancer drug for the treatment of many solid cancers.DNA damage thought to be key mechanism cisplatin's activity.However, cisplatin may also affect cellular metabolism.The aim this study was determine effect on types ATP production (OXPHOS versus glycolysis) and their rate in prostate cancer cells potentially protective autophagy amino acids during treatment.We wanted investigate potential synergy between metabolic effects inhibition...
Neuroblastoma represents a malignancy of the sympathetic nervous system characteristic by biological heterogeneity. Thus, chemotherapy exhibits only low effectivity in curing high-risk forms. Previous studies revealed cytotoxic potential valproate on neuroblastoma cells. Nevertheless, these omitted effects hypoxia, despite its undeniable tumorigenic role. In this study, we addressed question whether promotes binding platinum-based anti-cancer drugs (cisplatin, carboplatin and oxaliplatin) to...