A5092014489- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Oral health in cancer treatment
- Peptidase Inhibition and Analysis
- Mitochondrial Function and Pathology
- Head and Neck Cancer Studies
- Circular RNAs in diseases
- Proteoglycans and glycosaminoglycans research
- Cancer-related gene regulation
- MicroRNA in disease regulation
Masaryk University
2023-2024
Abstract Extracellular vesicles (EVs) are important mediators of intercellular communication in the tumour microenvironment. Many studies suggest that cancer cells release higher amounts EVs exposing phosphatidylserine (PS) at surface. There lots interconnections between biogenesis and autophagy machinery. Modulation can probably affect not only quantity but also their content, which deeply influence resulting pro-tumourigenic or anticancer effect modulators. In this study, we found...
Induction of autophagy represents an effective survival strategy for nutrient-deprived or stressed cancer cells. Autophagy contributes to the modulation communication within tumor microenvironment. Here, we conducted a study metabolic and signaling implications associated with induced by glutamine (Gln) serum starvation PI3K/mTOR inhibitor inducer NVP-BEZ235 (BEZ) in head neck squamous cell carcinoma (HNSCC) line FaDu. We compared effect these different types induction on ATP production,...