A5029012447- Curcumin's Biomedical Applications
- Occupational and environmental lung diseases
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Shoulder Injury and Treatment
- Research in Cotton Cultivation
- Sirtuins and Resveratrol in Medicine
- Tendon Structure and Treatment
- Protease and Inhibitor Mechanisms
- Phagocytosis and Immune Regulation
- Exercise and Physiological Responses
- Retinoids in leukemia and cellular processes
- Flavonoids in Medical Research
- Vitamin D Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and biosynthesis
- Botulinum Toxin and Related Neurological Disorders
- Connective tissue disorders research
- Cerebral Palsy and Movement Disorders
Aarhus University Hospital
2021
University of Rome Tor Vergata
2008-2020
Sapienza University of Rome
2010
// Laura Masuelli 1 , Enrica Di Stefano Massimo Fantini 2 Rosanna Mattera Monica Benvenuto Marzocchella Pamela Sacchetti Chiara Focaccetti 3 Roberta Bernardini Ilaria Tresoldi Valerio Izzi Maurizio Mattei Giovanni Vanni Frajese 4 Florigio Lista 5 Andrea Modesti and Roberto Bei Department of Experimental Medicine, University Rome "Sapienza", Rome, Italy Clinical Sciences Translational "Tor Vergata", STA, Dipartimento di Scienze Motorie, Umane e della Salute, Università Roma, Foro Italico...
// Laura Masuelli 1 , Monica Benvenuto 2 Enrica Di Stefano Rosanna Mattera Massimo Fantini Giuseppina De Feudis Enrico Smaele Ilaria Tresoldi Maria Gabriella Giganti Andrea Modesti 2, 3 and Roberto Bei Department of Experimental Medicine, University Rome "Sapienza", Rome, Italy Clinical Sciences Translational "Tor Vergata", Center for Regenerative (CIMER), Correspondence to: Bei, email: bei@med.uniroma2.it Keywords: curcumin, malignant mesothelioma, apoptosis, autophagy, proliferation...
Malignant mesothelioma (MM) is a tumor arising from mesothelium. MM patients' survival poor. The polyphenol 4',5,7,-trihydroxyflavone Apigenin (API) "multifunctional drug". Several studies have demonstrated API anti-tumoral effects. However, little known on the in vitro and vivo effects of MM. Thus, we analyzed cell proliferation, cycle regulation, pro-survival signaling pathways, apoptosis, autophagy human mouse cells. We evaluated anti-tumor activities mice transplanted with #40a cells...
Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) represents the causal agent of a potentially fatal disease (coronavirus 2019) that is actually great global public health concern. SARS-COV-2 has diffused throughout world surprisingly fast demonstrating far greater infectivity than previously known human coronaviruses and it also responsible for an unusual high variety symptoms in affected patients. Since viruses need to penetrate cells replicate, one their most important...
Abstract Background Spasticity is present in more than 80% of the population with cerebral palsy (CP). The aim this study was to describe and compare use three spasticity reducing methods; Botulinum toxin-A therapy (BTX-A), Selective dorsal rhizotomy (SDR) Intrathecal baclofen (ITB) among children adolescents CP six northern European countries. Methods This registry-based included population-based data born 2002 2017 recorded follow-up programs for Sweden, Norway, Denmark, Iceland Scotland,...
The structure of a tendon is an important example complexity ECM three-dimensional organization. extracellular matrix (ECM) macromolecular network with both structural and regulatory functions. components belong to four major types macromolecules: the collagens, elastin, proteoglycans, noncollagenous glycoproteins. Tendons are made by fibrous, compact connective tissue that connect muscle bone designed transmit forces withstand tension during contraction. Here we show ultrastructural...
Matrix metalloproteinases (MMPs) exhibit an important function in extracellular matrix degradation. MMPs modulate the activation of growth factors, cytokines and metastasis. At present, effect exercise on serum levels MMP-2 -9 remains unclear. The aim present study was to investigate various physical activities circulating MMP‑2 ‑9 breast cancer (BC) survivors healthy subjects. A total 66 female subjects were enrolled study. cohort included 46 BC 20 divided into 5 groups: Group (17...
The structure of a tendon is an important example complexity ECM three-dimensional organization.The extracellular matrix (ECM) macromolecular network with both structural and regulatory functions.ECM components belong to four major types macromolecules: the collagens, elastin, proteoglycans, noncollagenous glycoproteins.Tendons are made by fibrous, compact connective tissue that connect muscle bone designed transmit forces withstand tension during contraction.Here we show ultrastructural...
Racemic Gossypol [(±)-GOS], composed of both (−)-GOS and (+)-GOS, is a small BH3-mimetic polyphenol derived from cotton seeds. (±)-GOS has been employed well tolerated by cancer patients. Head neck carcinoma (HNC) represents one the most fatal cancers worldwide, significant proportion HNC expresses high levels antiapoptotic Bcl-2 proteins. In this study, we demonstrate that inhibits cell proliferation induces apoptosis autophagy human pharynx, tongue, salivary gland lines mouse cells...
The antitumor activity induced by intratumoral vaccination with poxvirus expressing a tumor antigen was shown to be superior that subcutaneous vaccination. Salivary gland carcinomas overexpress ErbB2. Trastuzumab, monoclonal antibody ErbB2, proposed for salivary tumors treatment. We explored the effectiveness of recombinant vaccinia virus ErbB2/Neu (rV-neu T) vaccine in hampering growth transplanted Neu-overexpressing BALB-neu T cancer cells (SALTO) mice. male mice were subcutaneously...
The purpose of our study was to investigate the histological, histochemical and ultrastructural aspects proximal femoral growth plate in slipped capital epiphysis (SCFE).Eight core biopsies were performed during situ epiphysiodesis patients with SCFE that at pre-slipping stage two cases mild slipping (Southwick angle < 30°) six cases. After fixation, specimens processed for either histological or studies.The thicker than normal cases, 3:1 ratio between thickness resting zone other zones...
Acromioclavicular joint cyst (AJC) is a very uncommon condition of the shoulder observed in elderly patients, caused by degenerative acromioclavicular (AC) joint, frequently associated to rotator cuff tendon tear. There are two possible cause for formation. We report different cases AC synovial cyst, with and without tear.We cases, patients aged respectively 80 77 years, large AJC. In one case, was tear, while other did not present any evident lesion. Both cysts were successfully surgical...
Regular exercise improves physical function and quality of life reduces fatigue in cancer survivors; these health benefits could be due to the anti-inflammatory effects exercise. In this study we examined a whole-body programme dragon boat paddling on production reactive oxygen species (ROMs), antioxidant capacity (BAP) circulating levels several interleukins breast patients. Thirty four women surgically treated for were enrolled study: 20 them usually row boats recreationally while 14...
Endomorphin-1 (EM-1) is an endogenous opioid peptide selectively binding to μ receptors (MORs). Besides its analgesic effects on the central nervous system (CNS), it has been recently reported that EM-1 can cross blood-brain barrier (BBB) and diffuse into blood, behaving as analgesic/anti-inflammatory molecule peripheral tissues, thus leading hypothesis could represent a soluble modulator of immune cell functions. Interestingly, nothing known about possible monocytes, main circulating...
Clear cell hidradenoma (CCH) is a superficial adnexal tumor of the sweat glands. It generally appears on trunk or scalp and uncommon upper lower limbs; it extremely rare hand. CCH tend to be benign, with low malignancy risk. Treatment based complete surgical excision. We report case palm hand in an 83-year old patient. An male patient presented small mass palmar surface his left hand, which was progressively increasing over 5 years. The surgically excised after sonography sent for histologic...