A5058423460- Bone health and treatments
- Prostate Cancer Treatment and Research
- Biomarkers in Disease Mechanisms
- Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Genomics, phytochemicals, and oxidative stress
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- Sirtuins and Resveratrol in Medicine
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Tea Polyphenols and Effects
- Ginseng Biological Effects and Applications
- Phytochemicals and Antioxidant Activities
- Bone health and osteoporosis research
- Occupational and environmental lung diseases
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Protein Degradation and Inhibitors
- Prostate Cancer Diagnosis and Treatment
- Ginger and Zingiberaceae research
Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana
2024
University of Rome Tor Vergata
2018-2022
The main aim of this study was to investigate the putative association among presence prostate cancer cells, defined as osteoblast-like cells (POLCs), and showing expression typical morphological molecular characteristics osteoblasts, development bone metastasis within 5 years diagnosis, uptake 18F-choline evaluated by PET/CT analysis. To end, biopsies (n = 110) were collected comprising 44 benign lesions 66 malignant lesions. Malignant further subdivided into two groups: from patients that...
Abstract Head and neck cancer (HNC) has frequently an aggressive course for the development of resistance to standard chemotherapy. Thus, use innovative therapeutic drugs is being assessed. Bortezomib a proteasome inhibitor with anticancer effects. In vitro antitumoral activity was investigated employing human tongue (SCC-15, CAL-27), pharynx (FaDu), salivary gland (A-253) cell lines murine line (SALTO-5) originated from adenocarcinoma arising in BALB- neu T male mice transgenic oncogene...
The survival rate for head and neck cancer patients has not substantially changed in the last two decades. We previously showed that rV-neuT intratumoral injections induced an efficient antitumor response rejection of transplanted Neu (rat ErbB2/neu oncogene-encoded protein)-overexpressing salivary gland tumor cells BALB-neuT mice (BALB/c transgenic rat oncogene). However, reiterated poxviral vaccinations increase neutralizing antibodies to viral proteins humans prevent immune against...
Abstract Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh are deregulated in MM. Thus, molecules involved these pathways could be used for targeted therapy approaches. The aim of this study was to evaluate effects inhibitors Hh- (GANT-61) (Afatinib)-mediated when alone or combination, on growth, cell cycle, death autophagy, modulation transduction three human MM lines different histotypes....
Due to the increasing number of authorized events in European Union, it is crucial for official laboratories enforce market control detect and quantify genetically modified organisms. In this study, an in-house validation quantitative duplex ddPCR methods was performed involving MON87701, MON87769, MON89788 CV-127-9 assays with respect lectin reference gene. Since provide accurate quantification, show less sensitivity PCR inhibitors are more suitable multiplexing compared real-time PCR,...
Abstract Head and neck cancer (HNC) has frequently an aggressive course for the development of resistance to standard chemotherapy. Thus, use innovative therapeutic drugs is being assessed. Bortezomib a proteasome inhibitor with strong in vitro vivo anticancer effects. In antitumoral activity was investigated employing human pharynx (FaDu), tongue (SCC-15, CAL-27), salivary gland (A-253) cell lines murine line (SALTO-5) originated from adenocarcinoma arising BALB- neu T male mice transgenic...