A5020324875- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Bone health and treatments
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Biomarkers in Disease Mechanisms
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Cancer Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- Thyroid Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Circadian rhythm and melatonin
- Cardiac Structural Anomalies and Repair
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Advanced X-ray and CT Imaging
- Neuroendocrine Tumor Research Advances
- Advanced Radiotherapy Techniques
- Atherosclerosis and Cardiovascular Diseases
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 detection and testing
- HER2/EGFR in Cancer Research
Policlinico Tor Vergata
2017-2024
University of Rome Tor Vergata
2012-2023
ORCID
2022
San Raffaele University of Rome
2021
Saint Camillus International University of Health and Medical Sciences
2021
Istituto Neurologico Mediterraneo
2021
Azienda Ospedaliero Universitaria Ospedali Riuniti
2013
Ospedali Riuniti di Foggia
2011-2012
Centro di Riferimento Oncologico della Basilicata
2007
European Institute of Oncology
2005-2006
This study aims to investigate: (a) the putative association between presence of microcalcifications and expression both epithelial-to-mesenchymal transition bone biomarkers, (b) role in breast osteoblast-like cells (BOLCs) formation, (c) microcalcification composition cancer progression.
Background: this study aims to investigate the possible association among histopathologic features of carotid plaque instability, presence micro- or macrocalcifications, expression in situ inflammatory biomarkers, and occurrence major risk factors process a large series plaques. Methods: total 687 plaques from symptomatic asymptomatic patients were collected. Histological evaluation was performed classify calcium deposits micro macrocalcifications according their morphological (location...
In this study, we investigated the relationship between expression of main in situ markers breast cancer and presence osteoblast-like cells (BOLCs). We collected 100 biopsies. Serial paraffin sections were obtained from each biopsy to perform histological classifications immunohistochemical analyses (RUNX2, RANKL, vimentin, TGFβ, Ki67, CD44, ER, PR HER2). Linear regression analysis showed a positive significant correlation number BOLCs EMT-related (vimentin TGFβ), Ki67 ER. Conversely,...
This study aims to investigate the possible different roles of BMP-2 variants, cytoplasmic and nuclear variant, in both epithelial mesenchymal transition microcalcifications origin human breast cancers. To this end, situ expression was associated with main biomarkers (e-cadherin vimentin) molecules involved bone metabolisms (RUNX2, RANKL, SDF-1) by immunohistochemistry. In addition, presence microcalcifications. Our data showed a significant association among number BMP-2-positive cells...
The main aim of this study was to investigate the putative association among presence prostate cancer cells, defined as osteoblast-like cells (POLCs), and showing expression typical morphological molecular characteristics osteoblasts, development bone metastasis within 5 years diagnosis, uptake 18F-choline evaluated by PET/CT analysis. To end, biopsies (n = 110) were collected comprising 44 benign lesions 66 malignant lesions. Malignant further subdivided into two groups: from patients that...
The aim of this study was to investigate the persistence SARS-CoV-2 in post-mortem swabs subjects who died from infection. presence virus evaluated airways 27 positive patients at three different time points (T1 2 h; T2 12 T3 24 h) by real-time PCR. Detection antibodies performed Maglumi 2019-nCoV IgM/IgG chemiluminescence assay. viral RNA still detectable 70.3% cases within h after death and 66,6% up death. Our data showed an increase load 78,6% individuals (T3) comparison that (T1)....
The immune system plays an important role in the defense against neoplastic disease and responses show temporal changes related to circadian variations of antibodies, total lymphocytes peripheral blood cell mediated responses. In this study we evaluate, lymphocyte subpopulations interleukin-2 (IL-2) serum levels samples collected at four-hour intervals for 24-hours starting 06.00h from ten healthy subjects aged 65–79 years (mean age ± S.E. 67.28 ±3.11) suffering untreated non small lung...
The main aim of this study was to investigate the possible association between 18F–choline uptake and histopathological features prostate biopsies such as Gleason Group expression both epithelial mesenchymal transition (vimentin) bone mineralization (bone morphogenetics protein (BMP)-2, runt-related transcription factor 2 (RUNX2), receptor activator nuclear factor-κB ligand (RANKL), vitamin D (VDR), pentraxin 3 (PTX3) in situ biomarkers. To end, we enrolled 79 consecutive cancer patients...