A5044044754- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cutaneous lymphoproliferative disorders research
- Cerebrovascular and Carotid Artery Diseases
- Chronic Lymphocytic Leukemia Research
- Breast Lesions and Carcinomas
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Acute Myeloid Leukemia Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related Molecular Pathways
- Fungal Infections and Studies
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Cancer and Skin Lesions
- Soft tissue tumor case studies
- CNS Lymphoma Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Myasthenia Gravis and Thymoma
- Sarcoma Diagnosis and Treatment
- Estrogen and related hormone effects
- SARS-CoV-2 and COVID-19 Research
- Prostate Cancer Treatment and Research
University of Rome Tor Vergata
2015-2024
Policlinico Tor Vergata
2009-2023
St. Eugenio Hospital
2004
Policlinico Umberto I
1988
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a derived from precursors of cells. Cutaneous involvement represents often the first manifestation disease. We studied 45 skin biopsies 33 patients (M:F=7.25:1; median age: 71 y; age range: 30 to 89) with BPDCN delineate histopathologic and immunophenotypic features this Patients presented generalized (n=18), localized (n=6), or solitary (n=9) macules, plaques, and/or tumors. Staging investigations at presentation were negative in 20...
In the last decade, several studies have reported an unexpected and seemingly paradoxical inverse correlation between BMI incidence of cardiovascular diseases. This so called "obesity paradox effect" has been mainly investigated through imaging methods instead histologic evaluation, which is still best method to study instability carotid plaque. Therefore, purpose our was evaluate by histology role obesity in destabilization plaques interaction with age, gender other major cerebrovascular...
Background: this study aims to investigate the possible association among histopathologic features of carotid plaque instability, presence micro- or macrocalcifications, expression in situ inflammatory biomarkers, and occurrence major risk factors process a large series plaques. Methods: total 687 plaques from symptomatic asymptomatic patients were collected. Histological evaluation was performed classify calcium deposits micro macrocalcifications according their morphological (location...
Development and maintenance of healthy stratified epithelia require the coordination complex transcriptional programmes. The transcription factor p63, a member p53 family, plays crucial role in epithelial development homeostasis. Analysis p63-dependent transcriptome indicated that one important aspect p63 functions is regulation cell–cell cell–matrix adhesion However, limited knowledge exists on relevant molecules involved physiological formation. Similarly, data are available to understand...
There is recent mounting evidence that nanoparticles may have enhanced toxicological potential in comparison to the same material bulk form. The aim of this study was develop a new method for unmask asbestos nanofibers from Formalin-Fixed, Paraffin-Embedded tissue. an increasing amount enhance Formalin-Fixed (FFPE) For first time, we applied Energy Dispersive X-ray (EDX) microanalysis through transmission electron microscopy demonstrate presence histological specimens patients with possible...
Background: Surgical stress and anesthesia affect the patient9s immune system. Analysis of lymphocyte response after breast-conserving surgery was conducted to investigate differences between effects general local anesthesia. Materials Methods: Fifty-six patients with breast cancer were enrolled for BCS through or Total leukocytes, total lymphocytes, lymphocyte-subsets including CD3<sup>+</sup>, CD19<sup>+</sup>, CD4<sup>+</sup>, CD8<sup>+</sup>, CD16<sup>+</sup>CD56<sup>+</sup>...
Background/Aim: Positron emission tomography/computed tomography (PET/CT) with <sup>18</sup>F-fluorodeoxyglucose (18F-FDG) has recently been used to investigate lymph node (LN) metastases and several predictive features in patients breast cancer (BC). The aim of this study was assess the value non-invasive imaging procedure for axillary staging. Patients Methods: Fifty early primary unilateral, locally advanced, or recurrent invasive operable BC were enrolled. All underwent preoperative...
Structural abnormality of the 11q23 band (11q23+) bearing MLL gene translocation (MLL+) is a recurrent chromosome change observed in 3% to 7% acute lymphoblastic leukemias and 4% myeloblastic leukemias. The resolution conventional cytogenetics (CC) detecting rearrangement limited when translocative partner has telomeric location; furthermore, CC can barely discriminate between true 11q23+/MLL+ rearrangements clustering within 11q22~25 region without involvement (MLL–). We characterized...
Structural abnormality of the 11q23 band (11q23+) bearing MLL gene translocation (MLL+) is a recurrent chromosome change observed in 3% to 7% acute lymphoblastic leukemias and 4% myeloblastic leukemias. The resolution conventional cytogenetics (CC) detecting rearrangement limited when translocative partner has telomeric location; furthermore, CC can barely discriminate between true 11q23+/MLL+ rearrangements clustering within 11q22~25 region without involvement (MLL–). We characterized...
Clinical evidences have shown good results using dermal/epidermal substitutes (DESs) to treat diabetic foot ulcers. Recent studies suggest that, in addition their scaffold action, DESs may favor wound healing by influencing bed inflammatory cells. This study aims investigate whether DES influence the infiltrate and macrophages polarization toward a reparative phenotype. Fifteen patients with chronic ulcers been randomly enrolled: 5 treated only standard of care, served as control group (CG),...
Background/Aim: In 2016, in the United States, more than 50% of breast cancer (BC) cases were diagnosed patients older 60 years age. Our study aimed to estimate risk locoregional recurrence (LR) who underwent breast-conservative treatment (BCT), according Patients and Methods: This retrospective monocentric analyzed 613 BCT between 2003 2014. divided into groups age: Under70 (under 70 old) Over70 (above old). Margins width, histology results, prognostic predictive factors compared. Subgroup...
Renal denervation represents an emerging treatment for resistant hypertension in patients with end-stage renal disease, but data about the anatomic substrate of this are lacking. Therefore, aim study was to investigate morphological basis sympathetic hyperactivity setting hemodialysis identify anatomical that could warrant use new therapeutic approach.