A5102978563- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- Polyomavirus and related diseases
- Salmonella and Campylobacter epidemiology
- Biosensors and Analytical Detection
- Brucella: diagnosis, epidemiology, treatment
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Malaria Research and Control
- Animal Virus Infections Studies
- Advanced biosensing and bioanalysis techniques
- Bacillus and Francisella bacterial research
- Plant Virus Research Studies
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Burkholderia infections and melioidosis
- Parvovirus B19 Infection Studies
- Synthesis and biological activity
- COVID-19 and Mental Health
- Yersinia bacterium, plague, ectoparasites research
- Advanced Chemical Sensor Technologies
- Long-Term Effects of COVID-19
Ministry of Defence
2023-2024
Sapienza University of Rome
2023-2024
Azienda Sanitaria Locale Viterbo
2023
Istituto Superiore di Sanità
2014
Alexandria University
2014
Sana'a University
2014
University of Rome Tor Vergata
2014
Veterinary Medical Center
2011-2013
University of Florence
1994-2012
Azienda Ospedaliero-Universitaria Careggi
2001
Abstract Background The genome of Bacillus anthracis , the etiological agent anthrax, is highly monomorphic which makes differentiation between strains difficult. A Multiple Locus Variable-number tandem repeats (VNTR) Analysis (MLVA) assay based on 20 markers was previously described. It has considerable discrimination power, reproducibility, and low cost, especially since proposed can be typed by agarose-gel electrophoresis. However in an emergency situation, faster genotyping access to...
Data concerning the transmission of novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) in paucisymptomatic patients are lacking. We report an Italian case disease 2019 with multiple biological samples positive for SARS-CoV-2. This was detected using World Health Organization protocol on cases and contact investigation. Current discharge criteria impact extra-pulmonary SARS-CoV-2 discussed.
Abstract Background The genus Brucella contains highly infectious species that are classified as biological threat agents. timely detection and identification of the microorganism involved is essential for an effective response not only to warfare attacks but also natural outbreaks. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) a rapid method analysis samples. advantages this method, compared conventional techniques, rapidity, cost-effectiveness,...
Plasmodium vivax infection is known to be rare in West/Central Africa, the most accepted explanation being lack of expression erythroid Duffy antigen local human populations. negativity prevents parasite exploit entry mechanism on red blood cell surface. However, there are a growing number reported infections Duffy-negative individuals. Data P. circulation Cameroon limited. The aim study was evaluate presence, and its association with genotype West Cameroon. Overall, 484 samples were...
We investigated 400 cases of dengue-like illness in persons hospitalized during an outbreak Al Hudaydah, Yemen, 2012. Overall, 116 dengue and 49 chikungunya were diagnosed. Dengue virus type 2 was the predominant serotype. The co-circulation these viruses indicates that mosquitoborne infections represent a public health threat Yemen.
In the era of sustainability, use natural compounds as antimicrobial is rational selection to avoid release pollutants into environment. Among compounds, essential oils are characterized by reliable activity and their estimated grow in future, thus detection an asked point. Herein, we report electrochemical reagent-free paper-based device for oils, namely thymol, eugenol, carvacrol adding a few µL solution onto electrode. We functionalized working electrode drop casting with carbon black,...
Coronaviruses are a family of viruses that cause disease in mammals and birds. In humans, coronaviruses infections on the respiratory tract can be fatal. These both mild illnesses such as common cold lethal SARS, MERS, COVID-19. Air transmission represents principal mode by which people become infected SARS-CoV-2. To reduce risks air this powerful pathogen, we devised method inactivation based propagation electromagnetic waves area to sanitized. We optimized conditions controlled laboratory...
Two forms of human polyomavirus JC (JCV) genome are known based upon the structure transcriptional control region (TCR) virus: archetypal form, which is commonly detected in urine, and rearranged was first brain tissue from progressive multifocal leukoencephalopathy (PML) patients. The latter actually includes a group TCR variants that, relative to former, characterized by various deletions and/or duplications. aim this study establish whether or not correlation exists among type, spreading...
A collection of 3069 human sera collected in the area municipality Modena, Emilia Romagna, Italy, was retrospectively investigated for specific antibodies against Usutu (USUV) and West Nile viruses (WNV). All samples resulting positive using a preliminary screening test were analyzed with plaque reduction neutralization test. Overall, 24 confirmed as USUV (0.78%) 13 WNV (0.42%). The results suggest that 2012, circulating more than North‐eastern Italy.
For RNA viruses, helicases have long been recognized to play critical roles during virus replication cycles, facilitating proper folding and of viral RNAs, therefore representing an ideal target for drug discovery. SARS-CoV-2 helicase, the non-structural protein 13 (nsp13) is a highly conserved among all known coronaviruses, and, at moment, one most explored targets identify new possible antiviral agents. In present study, we six diketo acids (DKAs) as nsp13 inhibitors able block both...
To evaluate whether antibodies specific for the vaccinia virus (VV) are still detectable after at least 45 years from immunization. confirm that VV-specific endowed with capacity to neutralize Mpox (MPXV) in vitro. test a possible role of polyclonal non-specific activation maintenance immunologic memory.
Abstract Background Brucellosis, a zoonosis caused by the genus Brucella , has been eradicated in Northern Europe, Australia, USA and Canada, but remains endemic most areas of world. The strain biovar typing field samples isolated outbreaks is useful for tracing back source infection may be crucial discriminating naturally occurring versus bioterrorist events, being potential biological warfare agent. In last years MLVA-16 described spp. genotyping. MLVA band profiles resolved different...
West Nile Virus (WNV) is a flavivirus that requires an efficient humoral and cellular host response for the control of neuroinvasive infection. We previously reported existence six alternative open reading frame proteins in WNV genome, one which entitled WARF4 exclusively restricted to lineage I virus. able elicit antibodies infected horses; however, there was no direct experimental proof this novel protein. The purpose study demonstrate vitro production protein following infection cultured...
Difficulty in controlling SARS-CoV-2 transmission made the ability to inactivate viruses aerosols and fomites be an important attractive risk reduction measure. Evidence that light frequencies have inhibit microorganisms has already been reported by many studies which, however, focused on ultraviolet (UV) wavelengths, which are known induce potential injury humans. In present study, effect suspensions of a Light Emitting Diode (LED) device capable radiating non-hazardous visible spectrum...
Abstract The SARS‐CoV‐2 life cycle is strictly dependent on the environmental redox state that influences both virus entry and replication. A reducing environment impairs binding of spike protein (S) to angiotensin‐converting enzyme 2 receptor (ACE2), while a highly oxidizing thought favor S interaction with ACE2. Moreover, interferes homeostasis in infected cells promote oxidative folding its own proteins. Here we demonstrate synthetic low molecular weight (LMW) monothiol dithiol compounds...
Brucellosis is an important zoonosis caused by the genus Brucella. In addition Brucella represents potential biological warfare agents due to high contagious rates for humans and animals. Therefore, strain typing epidemiological tool may be crucial tracing back source of infection in outbreaks discriminating naturally occurring versus bioterroristic event. A Multiple Locus Variable-number tandem repeats (VNTR) Analysis (MLVA) assay based on 15 polymorphic markers was previously described....