A5047186428- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Legionella and Acanthamoeba research
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Estrogen and related hormone effects
- Antifungal resistance and susceptibility
- Bacterial biofilms and quorum sensing
- Genomics and Phylogenetic Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Biosensors and Analytical Detection
- Mosquito-borne diseases and control
- Water Treatment and Disinfection
- Pneumonia and Respiratory Infections
- Hepatitis Viruses Studies and Epidemiology
- Cytokine Signaling Pathways and Interactions
- HIV Research and Treatment
- Antibiotic Resistance in Bacteria
- Chronic Lymphocytic Leukemia Research
- Bacterial Identification and Susceptibility Testing
- Tuberculosis Research and Epidemiology
- Cytomegalovirus and herpesvirus research
- Viral Infections and Vectors
- Genital Health and Disease
University of Modena and Reggio Emilia
2015-2025
Policlinico di Modena
2012-2024
European Society of Clinical Microbiology and Infectious Diseases
2022-2024
Polyclinic General Hospital
2016
Tohoku University
2012
National Operating Committee on Standards for Athletic Equipment
2010
University of Palermo
2003
Abstract Mycobacterium tuberculosis and leprae have remained, for many years, the primary species of genus clinical microbiological interest. The other members genus, referred to as nontuberculous mycobacteria (NTM), long been underinvestigated. In last decades, however, number reports linking various NTM with human diseases has steadily increased treatment difficulties emerged. Despite availability whole genome sequencing technologies, limited effort devoted genetic characterization...
We report the first worldwide case of Usutu virus (USUV) neuroinvasive infection in a patient with diffuse large B cell lymphoma who presented fever and neurological symptoms was diagnosed meningoencephalitits. The cerebrospinal fluid positive for USUV, USUV also demonstrated serum plasma samples by RT-PCR sequencing. Partial sequences premembrane NS5 regions viral genome were similar to Vienna Budapest isolates.
Clinical course in hepatocellular carcinoma may be very different. We prospectively evaluated 96 patients with unsuitable for radical therapy to investigate factors that could influence survival. Clinical, pathologic, and molecular data of were analyzed by univariate multivariate analysis. The overall actuarial probability survival at year 1, 2, 3, 4, 5, 6 was 72%, 41%, 38%, 24%, 20%, 9%. At analysis, alpha-fetoprotein (AFP) ( P = .0082); alkaline phosphatase .0281); bilirubin .0076);...
Variant liver oestrogen receptor transcripts in hepatocellular carcinoma are associated with aggressive clinical course and unresponsiveness to tamoxifen. To evaluate the impact on survival tumour growth of megestrol (progestin drug acting at post-receptorial level) we enrolled 45 patients HCC characterized by variant receptors a prospective, randomized study vs. placebo. Presence was determined RT/PCR. 24 were no treatment 21 therapy 160 mg day–1. Results analysed Kaplan-Meier Cox methods....
Abstract We report two fatal cases of acute liver failure secondary to herpes simplex virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for prompt recognition reactivation these undergoing immunomodulatory treatment, may have potentially relevant clinical consequences.
The identification and typing of bacteria are very expensive time-consuming due to their growth times, the expertise needed. MALDI-TOF MS represents a fast technique, reproducible with molecular approaches. This technique is still poorly applied in Legionella surveillance estimation occurring only at genus level. aim this study was compare three sample preparation methods: direct smear (DS), extended (EDS), full extraction (E), using MALDI Biotyper, developing an in-house library. Moreover,...
Coinfection with hepatitis B (HBV) and C (HCV) viruses is associated a more severe liver disease, increased frequency in the development of hepatocellular carcinoma, resistance to interferon (IFN) therapy when performed standard dosages used single infections. In attempt verify whether outcome IFN patients coinfection can be improved, we have planned prospective, randomized trial medium high three times week for 6 months.Thirty HBV-HCV coinfection, chronic were receive either or 9 MU...
Carbapenem-resistant Acinetobacter baumannii (CRAB) infection outbreaks are difficult to control and sometimes require cohorting of CRAB-positive patients or temporary ward closure for environmental cleaning. We aimed at controlling the deadly 2018 CRAB outbreak in a 12 bed- intensive care unit (ICU) including 9 beds 220 m2 open space. implemented new multimodal approach without closure, temporarily limiting admissions.A five-component bundle was introduced reinforcement hand hygiene sample...
Legionella spp. are widespread bacteria in aquatic environments with a growing impact on human health. Between the 61 species, pneumophila is most prevalent diseases; contrary, non- species less detected clinical diagnosis or during environmental surveillance due to their slow growth culture and absence of specific rapid diagnostic/analytical tools. Reliable isolate identification essential estimate source infection, undertake containment measures, determine treatment. Matrix-assisted laser...
Abstract Legionella pneumophila, a Gram-negative bacillus, is the causative agent of Legionnaire’s disease, form severe community-acquired pneumonia. Infection can have high morbidity, with proportion patients requiring ICU admission, and up to 10% mortality, which exacerbated by lack efficacy typical empirical antibiotic therapy against spp. The fastidious nature entire Legionellaceae family historically required inclusion activated charcoal in solid medium remove growth inhibitors,...
Purpose: Several scoring systems to evaluate patients with hepatocellular carcinoma (HCC) exist. A good system should provide information on prognosis and guide therapeutic decisions. The presence of variant liver estrogen receptor (ER) transcripts in the tumor has been shown be strongest negative predictor survival HCC. aim this study was compare predictive value commonly applied clinical for HCC that evaluation ER (molecular system). Materials Methods: staged according Okuda...
J Oral Pathol Med (2012) 41 : 16–20 Background: cancer is the sixth most common malignancy in developed countries, representing almost 3% of malignant tumors. Tobacco use and alcohol consumption are well‐established risk factors. However, observation that patients with oral have not been exposed to these factors suggests additional causes may promote carcinogenesis. A link has suggested between human papillomavirus (HPV) cavity but significance HPV contribution carcinogenesis as well...
Fourteen mycobacterial strains isolated from pulmonary samples of independent patients in the state Pará (Brazil), and three Italy, were characterized using a polyphasic approach. Thorough genetic investigation, including whole-genome sequencing, demonstrated that belong to M. simiae complex, being most closely related Mycobacterium interjectum. For 14 strains, evidence emerged supporting their inclusion previously unreported species genus Mycobacterium, for which name paraense sp. nov. is...