A5005796282- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Malaria Research and Control
- Hemoglobinopathies and Related Disorders
- Retinal Diseases and Treatments
- Vascular Malformations Diagnosis and Treatment
- Agriculture and Farm Safety
- Antibiotics Pharmacokinetics and Efficacy
- Intracranial Aneurysms: Treatment and Complications
- Amyotrophic Lateral Sclerosis Research
- Colorectal Cancer Treatments and Studies
- Antibiotic Resistance in Bacteria
- Radiomics and Machine Learning in Medical Imaging
- Cardiac tumors and thrombi
- Cerebrovascular and Carotid Artery Diseases
- Pneumonia and Respiratory Infections
- Acute Lymphoblastic Leukemia research
- Pancreatic and Hepatic Oncology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Metabolism, Diabetes, and Cancer
- Retinal Development and Disorders
- Radiopharmaceutical Chemistry and Applications
- Neurogenetic and Muscular Disorders Research
University of Genoa
2014-2024
Ente Ospedaliero Ospedali Galliera
2021-2024
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale
2013-2022
Hôpital Paris Saint-Joseph
2011-2021
Hôpital Saint Joseph
2021
University of Perugia
2013
Cancer stem cells (CSCs) are considered the cell subpopulation responsible for breast cancer (BC) initiation, growth, and relapse. CSCs identified as self-renewing tumor-initiating cells, conferring resistance to chemo- radio-therapy several neoplasias. Nowadays, th (about 10mM)e pharmacological targeting of is an ineludible therapeutic goal. The antidiabetic drug metformin was reported suppress in vitro vivo CSC survival different tumors and, particular, BC preclinical models. However, few...
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The annual movements of migratory birds can contribute to the spread African ticks and tick-borne pathogens potential public health concern across Europe. aim study was investigate their role in possible introduction into European countries during spring migration. A total 2344 were collected three seasons from 1079 captured on Italian stop-over islands northbound Once identified, each tick tested by RT-PCR for presence Crimean-Congo hemorrhagic fever (CCHFV), West Nile (WNV), Usutu (USUV)...
Cerebral cavernous malformations (CCMs) are vascular lesions of the CNS characterized by abnormally enlarged capillary cavities. CCMs can occur as sporadic or familial autosomal dominant form. Familial cases associated with mutations in CCM1[K-Rev interaction trapped 1 (KRIT1)], CCM2 (MGC4607) and CCM3 (PDCD10) genes. In this study, a three-gene mutation screening was performed direct exon sequencing, cohort 95 Italian patients either familial, well on their at-risk relatives. Sixteen 16...
In 2012, serotypes 1 and 4 of bluetongue virus (BTV) entered co‑circulated in Sardinia. The following year, BTV‑1 spread all over Sardinia invaded Sicily the Italian Tyrrenian coast. 2014, this strain extensively mainland Italy, causing severe outbreaks. late BTV‑4 was detected Southern Italy (Apulia region). This study reports detection BTV species Culicoides (Diptera: Ceratopogonidae) collected during epidemics between 2012 2014. A total 2,925 pools (83,102 midges), sorted from 651...
West Nile virus (WNV) is one of the most serious public health threats that Europe and Mediterranean countries are currently facing. In Italy, WNV emerged in 1998 has been circulating since 2008. To tackle its continuous incursions, Italian national regional institutions set up a surveillance program, which includes serological screening sentinel horses, sentinel-chickens backyard poultry flocks on all equine neurological cases, resident captured wild dead birds, vectors. This communication...
Metformin is an antidiabetic drug which possesses antiproliferative activity in cancer cells when administered at high doses, due to its unfavorable pharmacokinetics. The aim of this work was develop a pharmacological tool for the release metformin proximity tumor, allowing local concentrations, and demonstrate vivo antitumor efficacy after prolonged exposition. A 1.2% w/w thermoresponsive parenteral formulation based on poloxamers P407 P124, injectable room temperature undergoing sol-gel...
SUMMARY West Nile virus (WNV) strains belonging to lineage 2 were detected and isolated from the tissues of a goshawk two carrion crows in Sardinia August 2012. According NS3 sequence analysis, Sardinian isolates shared high level similarity with those Italian which circulated 2011 homologous 2004 Hungarian isolate. Following human fatality reported Olbia, this study is first report spread enzootic circulation WNV Sardinia.
Abstract Background Lung perfusion defects (PDs) have been described in COVID-19 using dual-energy computed tomography pulmonary angiography (DE-CTPA). We assessed the prevalence and characteristics of PDs patients with suspected embolism (PE) negative CTPA. Methods This retrospective study included non-COVID-19 pneumonia groups DE-CTPA for PE. Two radiologists rated presence PD within lung opacities analyzed type pattern (i.e. homogeneous or heterogeneous). The clinical, biological,...
Bioavailability of deferasirox (DFX) is significantly affected by the timing administration relative to times and composition meals. Its elimination half-life also highly variable - in some patients as a result gene polymorphisms. Understanding whether plasma levels are related specific characteristics could help physicians devise drug regimen tailored individual patient.We analyzed concentrations (CDFX ) 80 with transfusion-dependent anemias, such thalassemia, high performance liquid...
The aim of the study was to recreate in-vitro artificial aqueous humor with same physico-chemical properties human be used as a standard matrix in chromatography assess drug concentration anterior and posterior chamber eye.The prepared according chemical compositions reported literature. then analysed via HPLC-UV method compared from 15 patients who underwent cataract surgery. Known concentrations widely-used ophthalmological drugs were added order whether it can explore ocular disposition...
SUMMARY West Nile virus (WNV) circulation dynamics in the context of urban environment is not yet elucidated. In this perspective, three groups eight rock pigeons ( Columbia livia ) were inoculated with WNV lineage 1 strains isolated Italy between 2009 and 2012. The did develop any clinical signs consistent acute infection. All animals seroconverted shed up to 15 days post-infection by oral or cloacal routes. all infected viraemia lasted for 4 post-infection. No WNV-specific gross...