A5081802715- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Epigenetics and DNA Methylation
- Viral Infections and Immunology Research
- Pharmacological Effects and Toxicity Studies
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Autopsy Techniques and Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory mediators and NSAID effects
- Bone and Joint Diseases
- Blood properties and coagulation
- RNA modifications and cancer
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- Cancer-related gene regulation
- Immune responses and vaccinations
- Folate and B Vitamins Research
- Blood Coagulation and Thrombosis Mechanisms
- Cholesterol and Lipid Metabolism
- Respiratory viral infections research
- Toxoplasma gondii Research Studies
- Kruppel-like factors research
University of Verona
2013-2024
Azienda Ospedaliera Universitaria Integrata Verona
2019-2024
Abstract Background The liver hormone hepcidin regulates iron homoeostasis that is often altered in hepatocellular carcinoma ( HCC ). Epigenetic phenomena control gene expression through a dynamic fashion; therefore, considering the plasticity of both and epigenetic mechanisms their role carcinogenesis, we investigated whether HAMP ) modulated by DNA methylation, thus affecting status human . Materials methods Thirty‐two patients affected nonviral were enrolled, main clinical biochemical...
Aim: Sickle cell disease (SCD) is a debilitating monogenic disorder of red blood cells, characterized by acute pain episodes during vaso-occlusive crises (VOCs). Here, we developed and validated medical app, SCD-MED-ALERT, for home management in patients with SCD. Methods: The SCD-MED-ALERT app multilingual standalone application iOS Android. It was proposed to young adult SCD (n = 47) attending comprehensive sickle centers within the Società Italiana Talassemie ed Emoglobinopatie (SITE)...
BACKGROUND The desire for pregnancy in sickle cell disease (SCD) women has become a true challenge hematologists, requiring multidisciplinary approach. Erythrocytapheresis (ECP) is an important therapeutic tool SCD, but only limited data on starting time and the effects of ECP during are available. STUDY DESIGN AND METHODS This double‐center retrospective cross‐sectional study total 46 single pregnancies SCD from January 2008 to June 2017. was started at 10.7 ± 5.2 weeks gestation,...
Colon cancer is one of the most frequent solid tumor and simultaneous diagnosis primary colon liver metastases occurs in about fourth cases. The current knowledge on epigenetic signatures, especially those related to hydroxymethylation tissue, synchronous metastasis blood circulating cells lacking. This study aimed investigate both methylcytosine (mCyt) hydroxymethylcytosine (hmCyt) status DNA individual patients from metastases, cancer-free tissues leukocytes. Patients undergoing curative...
Common variable immunodeficiency (CVID) is a primary characterized by the failure of B lymphocytes differentiation leading to deficient immunoglobulins secretion. The identified genetic defects account only for minority cases. importance cells immunophenotyping in classification CVID known. This procedure can identify alterations on cell surface molecules expression that could explain some immunological disorders characteristic CVID. Moreover, immunophenotypical aspects correlate with...
Polymorphisms within one-carbon metabolism genes have been largely studied in relation to cancer risk for the function of this pathway nucleotide synthesis and DNA methylation. Aims study were explore possible link among several common functional gene polymorphisms survival rate primary liver cancers, i.e., hepatocellular carcinoma cholangiocarcinoma, assess additional effect global methylation on mortality risk. Forty-seven patients genotyped ten polymorphisms: DHFR 19bp ins/del, TS...
Background Mechanisms underlying hepatocellular carcinoma (HCC) development are largely unknown. The role of trace elements and proteins regulating metal ions homeostasis, i.e. metallothioneins (MTs), recently gained an increased interest. Object the study was to investigate promoter DNA methylation in MTs transcriptional regulation possible prognostic significance serum HCC. Methods Forty-nine HCC patients were enrolled clinically characterized. Cu, Se, Zn contents measured by Inductively...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of disease 2019 (COVID-19), in which coagulation abnormalities and endothelial dysfunction play a key pathogenic role. Tissue factor (TF) expression triggered by dysfunction. Activated VII-antithrombin (FVIIa-AT) complex reflects indirectly FVIIa-TF interaction has been proposed as potential biomarker prothrombotic diathesis. FVIIa-AT plasma concentration was measured 40 patients (30 males 10 females; 64.8 ±...
To The Editor, In adults, the diagnosis and clinical management of atypical hemolytic uremic syndrome is still a challenge for hematologists [1-3]. Here, we report case 40-year-old previously healthy man presented to emergency department with fever (39.6°C) bilateral persistent foot pain. He has been 2 days earlier by his primary care doctor due lower extremities pain sensation low body temperature during physical activity. At admission, he was found diaphoretic, apyretic (reported...
Topic: 27. Thalassemias Background: Patients with Transfusion-Dependent β-thalassemia (TDT) are characterized by an impaired innate and adaptive immune response, mainly due to chronic transfusions iron overload. We recently reported early antibody response SARS-CoV-2 vaccination in TDT patients comparable that observed a control group of health-care workers (HCW). Nevertheless, the vaccine-induced anti-RBD antibodies declined more rapidly respect HCW, similarly healthy elderly subjects,...