A5010491075- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Blood disorders and treatments
- Otitis Media and Relapsing Polychondritis
- Spondyloarthritis Studies and Treatments
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Ocular Diseases and Behçet’s Syndrome
- Inflammatory Myopathies and Dermatomyositis
- Immune responses and vaccinations
- Parvovirus B19 Infection Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Gastrointestinal disorders and treatments
- Blood groups and transfusion
- Mast cells and histamine
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Alkaline Phosphatase Research Studies
- Kruppel-like factors research
- Psoriasis: Treatment and Pathogenesis
Federico II University Hospital
2024
University of Verona
2009-2018
Psoriatic arthritis (PsA) is an inflammatory whose pathogenesis poorly understood; it characterized by bone erosions and new formation. The diagnosis of PsA mainly clinical diagnostic biomarkers are not yet available. aim this work was to clarify some aspects the disease identify specific gene signatures in paired peripheral blood cells (PBC) synovial biopsies patients with PsA. Moreover, we tried that can be used practice.PBC 10 were study expression using Affymetrix arrays. values...
Endothelin-1 (ET-1) plays a pivotal role in vasoconstriction, fibrosis, and inflammation, the key features of systemic sclerosis (SSc). ET-1 receptors (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mtext>ET</mml:mtext></mml:mrow><mml:mrow><mml:mtext>A</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>and<mml:math...
Behçet disease (BD) is a chronic inflammatory multisystem characterized by oral and genital ulcers, uveitis, skin lesions. Disease etiopathogenesis still unclear. We aim to elucidate some aspects of BD pathogenesis identify specific gene signatures in peripheral blood cells (PBCs) patients with active using novel expression network analysis. 179 genes were modulated 10 PBCs when compared healthy donors. Among differentially expressed the top enriched function was immune response,...
Systemic sclerosis (SSc) is a rare connective tissue disease characterized by three pathogenetic hallmarks: vasculopathy, dysregulation of the immune system, and fibrosis. A particular feature SSc increased frequency some types malignancies, namely breast, lung, hematological malignancies. Moreover, may also be paraneoplastic disease, again indicating strong link between cancer scleroderma. The reason this association still unknown; therefore, we aimed at investigating whether genetic or...
Background Psoriatic arthritis (PsA) is a chronic inflammatory disease of unknown origin, characterized by erosions and new bone formation. Diagnosis PsA mainly clinical there are no biomarkers available. Moreover in autoantibodies have not been described so far. Indeed an autoimmune origin has suggested but never proven. Aim the study was to investigate possible presence typically associated with PsA. Methods We used pooled IgG immunoglobulins derived from 30 patients screen random peptide...
Background . Behçet’s disease (BD) is a chronic inflammatory multisystem characterized by oral and genital ulcers, uveitis, skin lesions. MicroRNAs (miRNAs) are key regulators of immune responses. Differential expression miRNAs has been reported in several autoimmune diseases; however, their role BD not fully elucidated. We aimed to identify miRNA signatures associated with investigate potential implication the pathogenesis. Methods microarray analysis was performed blood cells patients...
Background . Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by bone erosions and new formation. MicroRNAs (miRNAs) are key regulators of the immune responses. Differential expression miRNAs has been reported in several autoimmune diseases; however, their role PsA not fully elucidated. We aimed to identify miRNA signatures associated with investigate potential implication disease pathogenesis. Methods microarray was performed blood cells patients healthy controls....
Psoriatic arthritis (PsA) is an inflammatory arthritis, characterised by inflammation of entheses and synovium, leading to joint erosions new bone formation. It affects 10% 30% patients with psoriasis, has estimated prevalence approximately 1%. PsA considered be primarily autoimmune disease, driven autoreactive T cells directed against autoantigens present in the skin joints. However autoinflammatory origin recently been proposed. Long noncoding RNAs (lncRNAs) are more than 200 nucleotides...
The CD30/CD30L signalling system has been implicated in the pathogenesis of several autoimmune and inflammatory conditions. In rheumatoid arthritis (RA), soluble CD30 (sCD30) levels reflect recruitment + T cells into inflamed joints correlate with a positive response to immunosuppressive therapy. aim our report was clarify role RA. Our analysis CD30L cell subsets peripheral blood (PB) synovial fluid (SF) RA patients related cytokine profiles suggests involvement polarization towards Th17...
Background Regular intravenous immunoglobulin treatment is used to replace antibody deficiency in primary immunodeficiency diseases; however the therapeutic effect seems be related not only replacement but also an active role modulation of immune response. Common variable most frequent seen clinical practice. Methods We have studied patients with common by evaluating gene-expression profiles from Affimetrix HG-U133A. Some gene array results were validated real time RT-PCR and measurement...
The etiology of Ankylosing spondylitis (AS) is still unknown and the identification involved molecular pathogenetic pathways a current challenge in study disease. Adalimumab (ADA), an anti-tumor necrosis factor (TNF)-alpha agent, used treatment AS. We aimed at identifying modified by ADA patients with good response to treatment. Gene expression analysis Peripheral Blood Cells (PBC) from six responders four not responder was performed before after Differentially expressed genes (DEGs) were...
Common variable immunodeficiency (CVID) is a primary characterized by the failure of B lymphocytes differentiation leading to deficient immunoglobulins secretion. The identified genetic defects account only for minority cases. importance cells immunophenotyping in classification CVID known. This procedure can identify alterations on cell surface molecules expression that could explain some immunological disorders characteristic CVID. Moreover, immunophenotypical aspects correlate with...
Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. We describe the case of 20-year-old man from India living in Italy since 2003, who presented with erythematous papules and nodules distributed on his arms, legs, face 2006. He also had episodes high fever, polyarthritis, episcleritis. Sarcoidosis was suspected basis elevated angiotensin-converting enzyme bronchoalveolar lavage fluid, patient treated corticosteroids for about year. A flare occurred each time...
Abstract: Systemic sclerosis (SSc) is an autoimmune disease characterized by immune dysfunction and abnormalities of the microvasculature with vascular obliteration, eventually leading to fibrosis skin, gastrointestinal tract, lungs, heart, kidney. The etiology pathogenesis SSc remain unclear, despite recent significant progress in field. Immune activation microangiopathy are followed widespread organ fibrosis, failure increased mortality. production inflammatory cytokines growth factors...
Abstract Purpose Inborn errors of immunity (IEI) represent a heterogeneous group rare genetically determined diseases. In some cases, patients present with complex or atypical phenotypes, not fulfilling the accepted diagnostic criteria for IEI and, thus, at high risk misdiagnosis delay. This study aimed to validate platform that, through opinion immunologist experts, improves process and level care atypical/complex IEI. Methods Here, we describe functioning IEI-Virtual Consultation System...
A 30-year-old male presented at the emergency room with itchy, erythematous skin lesions that had recently worsened, becoming more diffuse, exfoliated, and scaly. He also joint pain in his wrists, knees, ankles. Given symptoms, a physical examination, anamnestic data, diagnosis of erythrodermic psoriasis psoriatic arthritis was made. The patient treated and, after observation overnight, discharged following day.