A5003607573- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Inflammatory Bowel Disease
- Microscopic Colitis
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Orthopaedic implants and arthroplasty
- Helicobacter pylori-related gastroenterology studies
- Cancer Research and Treatments
- Bone Tissue Engineering Materials
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Gut microbiota and health
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Heavy Metal Exposure and Toxicity
- Cervical Cancer and HPV Research
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
Università Cattolica del Sacro Cuore
2016-2025
Agostino Gemelli University Polyclinic
2002-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2024
Centro di Riferimento Oncologico della Basilicata
2004-2024
Catholic University of America
2005-2023
Chinese Academy of Sciences
2019
Tianjin Medical University
2019
Translational Therapeutics (United States)
2019
University of Pennsylvania
2019
University of Chieti-Pescara
2013-2019
Several in vitro and vivo studies suggest local systemic effects following exposure to carbon nanotubes. No data are available, however, on their possible embryotoxicity mammals. In this study, we tested the effect of pristine oxidized single-wall nanotubes (SWCNTs) development mouse embryo. To end, SWCNTs (from 10 ng 30 μg/mouse) were administered female mice soon after implantation (postcoital day 5.5); days later, animals sacrificed, uteri, placentas, fetuses examined. A high percentage...
We investigated whether platelets prime colon cancer cells for metastasis and pharmacological inhibition of platelet function may prevent it. Coculturing HT29 human carcinoma with led to the induction mesenchymal-like characterized by downregulation E-cadherin upregulation Twist1, enhanced cell mobility a proaggregatory action on platelets. These changes were prevented different antiplatelet agents, aspirin[an inhibitor cyclooxygenase(COX)-1], DG-041[an antagonist prostaglandin(PG)E2 EP3...
Abstract Antimicrobial peptides (AMPs) play a key role in the innate immunity, first line of defense against bacteria, fungi, and viruses. AMPs are small molecules, ranging from 10 to 100 amino acid residues produced by all living organisms. Because their wide biodiversity, insects among richest most innovative sources for AMPs. In particular, insect Hermetia illucens (Diptera: Stratiomyidae) shows an extraordinary ability live hostile environments, as it feeds on decaying substrates, which...
Cyclooxygenase (COX)-2–derived prostanoids can influence several processes that are linked to carcinogenesis. We aimed address the hypothesis platelets contribute aberrant COX-2 expression in HT29 colon carcinoma cells and reveal role of platelet-induced on proteins involved malignancy marker genes epithelial-mesenchymal transition (EMT). Human cocultured with rapidly adhered cancer induced mRNA expression, but not protein synthesis, which required late release platelet-derived growth factor...
Abstract The CD40/CD40 ligand (CD40L) pathway is involved in Crohn’s disease (CD) pathogenesis. In the patients’ circulation, soluble CD40L (sCD40L) levels are elevated and surface increased platelets T cells, whereas intestine CD40 overexpressed microvasculature cells. therapeutic effects of infliximab CD attributed to its systemic anti-TNF-α action, but because TNF-α modulates both CD40L, we investigated whether affects CD40/CD40L intestine. Eighteen patients were evaluated before after...
Increased homocysteine contributes to the pathophysiology of several chronic inflammatory diseases. Whether could participate in mucosal inflammation bowel disease (IBD) has not been explored yet. Our aims were study levels plasma and IBD patients assess whether can trigger an reaction on human intestinal microvascular endothelial cells (HIMECs).Homocysteine was measured plasma, biopsy, lamina propria mononuclear cell (LPMC) supernatants from normal subjects. HIMEC cultured presence...
Pleuro-pulmonary solitary fibrous tumor (SFT) is a relatively uncommon mesenchymal neoplasm of uncertain histogenesis, unknown molecular features, and unpredictable clinical behavior. Although complete resection universally accepted as the most important single prognostic factor, some clinicopathologic characteristics (gross appearance, size, mitotic index, necrosis, hypercellularity, pleomorphism) are related to patient outcome, staging system based on these parameters with practical...
Regulation of cell mechanics allows cancer cells to acquire specialized functions. Primary tumor soft rounded are responsible for volume increase, while elongated stiff invade neighbouring tissues. Once reached the lymph node, reorganize actin and increase adhesion cope with high shear forces.