A5013507502- Prenatal Substance Exposure Effects
- Cannabis and Cannabinoid Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Prenatal Screening and Diagnostics
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Homelessness and Social Issues
- Testicular diseases and treatments
- Pancreatic function and diabetes
- LGBTQ Health, Identity, and Policy
- Metabolism, Diabetes, and Cancer
- Maternal and Perinatal Health Interventions
- Ethics and Legal Issues in Pediatric Healthcare
- Genetics and Neurodevelopmental Disorders
- Sleep and related disorders
- Genetic Syndromes and Imprinting
University of Colorado Denver
2022-2025
Children's Hospital Colorado
2024-2025
Colorado Center For Hospice and Palliative Care
2025
University of Colorado Anschutz Medical Campus
2022-2024
Background: Prenatal exposure to cannabis may influence childhood cognition and behavior, but the epidemiologic evidence is mixed. Even less known about potential impact of secondhand during early childhood. Objective: This study sought assess whether prenatal and/or postnatal was associated with behavior. Study design: sub-study included a convenience sample 81 mother–child pairs from Colorado-based cohort. Seven common cannabinoids (including delta 9-tetrahydrocannabinol (Δ9-THC)...
Abstract Thousands of people suffer from nausea with pregnancy each year. Nausea can be alleviated cannabidiol (CBD), a primary component cannabis that is widely available. However, it unknown how fetal CBD exposure affects embryonic development and postnatal outcomes. binds activates receptors are expressed in the brain important for development, including serotonin (5HT 1A ), voltage-gated potassium (Kv)7 receptors, transient potential vanilloid 1 receptor (TRPV1). Excessive activation...
ABSTRACT Sex chromosome aneuploidies (SCAs) are chromosomal variations that result from an atypical number of X and/or Y chromosomes. Combined, SCAs affect ~1/400 live births, including individuals with Klinefelter syndrome (47, XXY), Turner (45, and variants), Double XYY), Trisomy XXX), rarer tetrasomies pentasomies. Individuals experience a wide variety physical health, mental healthcare experiences differ the standard population. To understand priorities SCA community we surveyed...
Abstract Objective: To understand labor and delivery nurses' attitudes behaviors toward pregnant patients with substance use disorders or mental health concerns. Suicide overdose are among the leading causes of preventable maternal deaths nationwide, underscoring urgency addressing issues related to supporting behavioral Design: We surveyed a subpopulation nurses in Colorado Results: Survey respondents were 154 from 14 hospitals that represented 45% state's 2022 births: Half reported their...
Metformin is used by women during pregnancy to manage diabetes and crosses the placenta, yet its effects on fetus are unclear. We show that liver a site of metformin action in fetal sheep macaques, given relatively abundant OCT1 transporter expression hepatic uptake following infusion into sheep. To determine action, we performed studies primary hepatocytes from sheep, juvenile macaques. increases AMP-activated protein kinase (AMPK) signaling, decreases mammalian target rapamycin (mTOR)...
Abstract Unintentional overdose is a leading driver of maternal death in Colorado. The high volume deaths from preventable causes lends questions to failures our clinical and community‐based care for pregnant postpartum people. Colorado Maternal Mortality Review Committee identified 3 main contributors including stigma the community health system, fragmentation need more clinician training. Perinatal Care Quality Collaborative led 3‐pronged intervention address these challenges improve...
Sex chromosome aneuploidies (SCAs) are chromosomal variations that result from an atypical number of X and/or Y chromosomes. Combined, SCAs affect ~1/400 live births, including individuals with Klinefelter syndrome (47,XXY), Turner (45,X and variants), Double (47,XYY), Trisomy (47,XXX), rarer tetrasomies pentasomies. Individuals experience a wide variety physical health, mental healthcare experiences differ the standard population. To understand priorities SCA community we surveyed...
Background and objectives: Sex chromosome trisomy (SCT) is a common chromosomal abnormality associated with increased risks for early developmental delays neurodevelopmental disorders later in childhood. Our objective was to quantify the spectrum of milestones SCT. We hypothesized milestone achievement SCT than general population. Methods: Data were collected as part eXtraordinarY Babies Study, prospective natural history health trajectories prenatally identified sample infants Parent...
Abstract Thousands of people suffer from nausea with pregnancy each year. Nausea can be alleviated cannabidiol (CBD), a primary component cannabis that is widely available. However, it unknown how fetal CBD exposure affects embryonic development and postnatal outcomes. binds activates receptors are important for expressed in the brain, including serotonin (5HT 1A ), voltage-gated potassium (Kv)7 receptors, transient potential vanilloid 1 receptor (TRPV1). Excessive activation these during...
ABSTRACT Sex chromosome aneuploidies (SCAs) are a family of genetic disorders that result from an atypical number X and/or Y chromosomes. SCAs the most common chromosomal abnormality, affecting ∼1/400 live births, yet often underdiagnosed, leading to over-representation more severely impacted individuals in many clinical studies. In addition this ascertainment bias, existing work has also been limited by low geographic and demographic diversity. To address these limitations, we have created...
Abstract Introduction Hypergonadotropic hypogonadism is a characteristic clinical manifestation of Turner syndrome (TS). While up to 30% and 20% people with TS will have spontaneous thelarche menarche respectively, there lack evidence predict who retain sufficient ovarian function achieve these outcomes. The aim this study was determine if follicle-stimulation hormone (FSH) and/or luteinizing (LH) concentrations measured in infancy would accurately later or menarche. Methods Patients...
ABSTRACT Context 47,XXY/Klinefelter syndrome (XXY) is associated with impaired testicular function and differences in physical growth, metabolism, neurodevelopment. Clinical features of XXY may be attributable to inadequate testosterone during the mini-puberty period infancy. Objective We tested hypothesis that exogenous treatment positively effects short-term physical, hormonal, neurodevelopmental outcomes infants XXY. Design Double-blind randomized controlled trial, 2017-2021 Setting US...
<p>Metformin is used by women during pregnancy to manage diabetes and crosses the placenta, yet its effects on fetus are unclear. We show that liver a site of metformin action in fetal sheep macaques, given relatively abundant<em> OCT1</em> transporter expression hepatic uptake following infusion into sheep. To determine action, we performed studies primary hepatocytes from sheep, juvenile macaques. Metformin increases AMP-activated protein kinase (AMPK) signaling,...
<p>Metformin is used by women during pregnancy to manage diabetes and crosses the placenta, yet its effects on fetus are unclear. We show that liver a site of metformin action in fetal sheep macaques, given relatively abundant<em> OCT1</em> transporter expression hepatic uptake following infusion into sheep. To determine action, we performed studies primary hepatocytes from sheep, juvenile macaques. Metformin increases AMP-activated protein kinase (AMPK) signaling,...
Objective: To assess whether fetal exposure to cannabis is associated with childhood behavior, independent of nicotine. Study design: This pilot study included 97 mother-child pairs from a Colorado-based cohort. Maternal urine was collected at ~27 weeks gestation and analyzed for cotinine twelve cannabinoids/metabolites (including delta 9-tetrahydrocannabinol cannabidiol). Fetal dichotomized as exposed (any cannabinoid≥limit detection [LOD]) not exposed. nicotine (cotinine≥LOD) Generalized...
Welcome to the 2021 Virtual Cannabis Research Conference! This three-day, comprehensive conference explores new cannabis research frontiers in medicine, science, and society. Visit CRC Exhibit Hall, between 8:00 am - 4:30 pm MT meet exhibitors. | Turn your camera & mic on visit Networking Lounge. Mingle with other attendees around clock. Visit: [Conference Program Book](https://online.fliphtml5.com/wowbk/dwbj/#p=1) [Virtual...