A5051361990- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neuroscience of respiration and sleep
- Prenatal Substance Exposure Effects
- Advanced Memory and Neural Computing
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
University of Colorado Denver
2022-2024
University of Colorado Anschutz Medical Campus
2022-2023
Abstract Serotonin (5-HT) imbalances in the developing prefrontal cortex (PFC) are linked to long-term behavioral deficits. However, synaptic mechanisms underlying 5-HT-mediated PFC development unknown. We found that chemogenetic suppression and enhancement of 5-HT release during first two postnatal weeks decreased increased density strength excitatory spine synapses, respectively, on layer 2/3 pyramidal neurons mice. single spines induced structural functional potentiation (LTP), requiring...
Abstract Thousands of people suffer from nausea with pregnancy each year. Nausea can be alleviated cannabidiol (CBD), a primary component cannabis that is widely available. However, it unknown how fetal CBD exposure affects embryonic development and postnatal outcomes. binds activates receptors are expressed in the brain important for development, including serotonin (5HT 1A ), voltage-gated potassium (Kv)7 receptors, transient potential vanilloid 1 receptor (TRPV1). Excessive activation...
Dendritic spines can be directly connected to both inhibitory and excitatory presynaptic terminals, resulting in nanometer-scale proximity of opposing synaptic functions. While dually innervated (DiSs) are observed throughout the central nervous system, their developmental timeline functional properties remain uncharacterized. Here we used a combination serial section electron microscopy, live imaging, local synapse activity manipulations investigate DiS development function rodent...
Abstract Bidirectional trans ‐synaptic signaling is essential for the formation, maturation, and plasticity of synaptic connections. Synaptic cell adhesion molecules (CAMs) are prime drivers in shaping identities pathways. A series recent studies provide evidence that diverse presynaptic proteins dictate regulation specific properties postsynaptic neurons. Focusing on mammalian CAMs, this article outlines several exemplary cases supporting notion highlights how these pathways collectively...
Abstract Thousands of people suffer from nausea with pregnancy each year. Nausea can be alleviated cannabidiol (CBD), a primary component cannabis that is widely available. However, it unknown how fetal CBD exposure affects embryonic development and postnatal outcomes. binds activates receptors are important for expressed in the brain, including serotonin (5HT 1A ), voltage-gated potassium (Kv)7 receptors, transient potential vanilloid 1 receptor (TRPV1). Excessive activation these during...