A5007526227- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Substance Abuse Treatment and Outcomes
- Obesity, Physical Activity, Diet
- Alcohol Consumption and Health Effects
- Child and Adolescent Psychosocial and Emotional Development
- Botulinum Toxin and Related Neurological Disorders
- Eating Disorders and Behaviors
- Treatment of Major Depression
- Infant Health and Development
- Behavioral Health and Interventions
- Bipolar Disorder and Treatment
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Alcoholism and Thiamine Deficiency
- Child and Adolescent Health
- Maternal Mental Health During Pregnancy and Postpartum
- Adolescent and Pediatric Healthcare
- Obsessive-Compulsive Spectrum Disorders
- Youth Substance Use and School Attendance
- Attention Deficit Hyperactivity Disorder
- Neural dynamics and brain function
- Diet and metabolism studies
University of Colorado Denver
2019-2021
University of Colorado Anschutz Medical Campus
2018-2021
Denver Health Medical Center
2019
Department of Behavioral Health
2019
Health and Hospital Corporation
2019
Summary Background Recent work has implicated disinhibited eating behaviours (DEB) as a potential pathway toward obesity development in children. However, the underlying neurobiology of young, healthy weight children, prior to development, remains unknown. Objectives This study tested relationship between DEB and intrinsic neuronal activity connectivity young children without obesity. Methods Brain networks overeating including reward, salience executive control networks, default mode...
Background: While case series have established the efficacy of deep brain stimulation (DBS) in treating obsessive-compulsive disorder (OCD), it has been our experience that few OCD patients present without comorbidities affect outcomes associated with DBS treatment. Here we therapy for who all comorbid disease, together results programming strategies. Methods: For this series, assessed five underwent ventral capsule/ventral striatum (VC/VS) between 2015 and 2019 at University Colorado...
Background Acute alcohol produces effects on cerebral metabolism and blood flow. Alcohol is converted to acetate, which serves as a source of energy for the brain an agonist at G protein‐coupled receptors distributed in different cell types body including neurons. Acetate has been hypothesized play role flow (CBF) response after ingestion. We tested whether administration acetate would alter CBF pattern similar or from that ingestion healthy individuals. Methods Twenty‐four participants were...
Children visiting emergency departments (EDs) are disproportionately affected by mental health disorders. Integrated behavioral models hold promise for improving care among ED patients. We implemented and evaluated a novel service integrated psychology trainees in safety net hospital's pediatric urgent care.Consultations interventions provided were identified from the service's patient registry. Patients treated matched based on age, sex, day, month of presentation to control patients who...
Objectives: Evaluate the association between school-based treatment of substance use disorders and academic outcomes by developing a system simple easily tracked performance metrics coinciding with an established program. Methods: This study provided to 75 high school students enrolled without exclusion who voluntarily sought care for disorders. Participants were in 12-week program individual motivational interviewing, acceptance commitment therapy, family sessions, case management,...
Applications of quantitative network analysis to functional brain connectivity have become popular in the last decade due their ability describe general topological principles networks. However, many issues arise when standard statistical techniques are applied magnetic resonance imaging (fMRI) maps. Frequently, summary measures these maps, such as global efficiency and clustering coefficients, collapse changing structures graph topology from scales one. This can result a loss whole-brain...
Objective The impact of in utero exposure to maternal overweight and obesity on offspring metabolic health is well documented. Neurodevelopmental outcomes among these children are, however, less studied. To address this gap, the current study investigated brain function 4‐ 6‐year‐old exposed or during gestation compared with that born mothers healthy BMI pregnancy. Methods Resting‐state functional magnetic resonance imaging was used neuronal activity connectivity a passive viewing task...
Connectivity within the human connectome occurs between multiple neuronal systems—at small to very large spatial scales. Independent component analysis (ICA) is potentially a powerful tool facilitate multi-scale analyses. However, ICA has yet be fully evaluated at low (10 or fewer) and ultra-high dimensionalities (200 greater). The current investigation used data from Human Connectome Project (HCP) determine following: (1) if larger networks, meta-networks, are present dimensionality, (2)...
Neuroimaging studies using functional magnetic resonance imaging (fMRI), which measures brain activity by detecting the changes in blood oxygenation levels, are advancing our understanding of pathophysiology dystonia. Neurobiological disturbances dystonia, however, may affect neurovascular coupling and impact interpretability fMRI studies. We evaluated here whether hemodynamic response patterns during a behaviorally matched motor task altered isolated cervical dystonia (CD). Twenty-five CD...
Alcohol use disorders (AUDs) are associated with altered regulation of physiological processes in the brain. Acetate, a metabolite ethanol, has been implicated several that disrupted AUDs including transcriptional regulation, metabolism, inflammation, and neurotransmission. To further understand effects acetate on brain function AUDs, we investigated cerebral blood flow (CBF), systemic inflammatory cytokines, behavior AUD.
Abstract Applications of quantitative network analysis to functional brain connectivity have become popular in the last decade due their ability describe general topological principles networks. However, many issues arise when standard statistical techniques are applied magnetic resonance imaging (fMRI) maps. Frequently, summary measures these maps, such as global efficiency and clustering coefficients, collapse changing structures graph topology from scales one. This can result a loss...