A5078040270- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Telomeres, Telomerase, and Senescence
- Advanced Proteomics Techniques and Applications
- Biochemical effects in animals
- Advanced biosensing and bioanalysis techniques
- Cerebrovascular and genetic disorders
- Diet and metabolism studies
- Advanced Biosensing Techniques and Applications
- Health, Environment, Cognitive Aging
- Forensic Toxicology and Drug Analysis
- Liver Disease and Transplantation
- GDF15 and Related Biomarkers
- Computational Drug Discovery Methods
- Immune responses and vaccinations
- Single-cell and spatial transcriptomics
- Click Chemistry and Applications
- Cannabis and Cannabinoid Research
- S100 Proteins and Annexins
- CRISPR and Genetic Engineering
- Psychedelics and Drug Studies
- Cardiovascular Health and Risk Factors
- Bone Tumor Diagnosis and Treatments
National Institute on Aging
2022-2024
National Institutes of Health
2022-2024
Division of Cancer Epidemiology and Genetics
2024
National Cancer Institute
2023-2024
United States Department of Health and Human Services
2024
Center for Cancer Research
2023
Institute on Aging
2022
Maimonides Medical Center
2018
Loyola University Chicago
2018
Manhattan Psychiatric Center
2018
SomaScan is a high-throughput, aptamer-based proteomics assay designed for the simultaneous measurement of thousands proteins with broad range endogenous concentrations. In its most current version, 7k v4.1 capable measuring 7288 human proteins. this work, we present an extensive technical assessment platform based on study 2050 samples across 22 plates. Included in design were inter-plate duplicates from 102 subjects, which allowed us to characterize different normalization procedures,...
Dysregulation of the immune system and dietary patterns that increase inflammation can risk for cognitive decline, but mechanisms by which inflammatory nutritional habits may affect development impairment in aging are not well understood. To determine whether plasma proteins linked to diet predict future impairment, we applied high-throughput proteomic assays samples from a subset (n = 1528) Women's Health Initiative Memory Study (WHIMS) participants (mean [SD] baseline age, 71.3 [SD 3.8]...
Abstract Infections have been associated with the incidence of Alzheimer disease and related dementias, but mechanisms responsible for these associations remain unclear. Using a multicohort approach, we found that influenza, viral, respiratory, skin subcutaneous infections were increased long-term dementia risk. These also region-specific brain volume loss, most commonly in temporal lobe. We identified 260 out 942 immunologically relevant proteins plasma differentially expressed individuals...
Few studies have comprehensively examined how health and disease risk influence Alzheimer's (AD) biomarkers. The present study the association of 14 protein-based indicators with plasma neuroimaging biomarkers AD neurodegeneration.
Abstract Cerebral small vessel disease (SVD), as defined by neuroimaging characteristics such white matter hyperintensities (WMHs), cerebral microhemorrhages (CMHs), and lacunar infarcts, is highly prevalent has been associated with dementia risk other clinical sequelae. Although conditions hypertension are known to contribute SVD, little about the diverse set of subclinical biological processes molecular mediators that may also influence development progression SVD. To better understand...
Ecstasy, a popular drug among the younger generation, primary psychoactive component of which is 3,4-Methylenedioxymethamphetamine (MDMA), rarely known to have acute psychiatric effects and when it does, usually short term. We describe patient who presented emergency room in psychotic state after using ecstasy recreationally. Given his aggressive behavior community risk for self-harm, he was emergently hospitalized ensure safety. He developed persistent symptoms (delusions) one dose...
Abstract Base editing encompasses techniques that efficiently alter specific nucleotides at the DNA or RNA level. Initially explored for inherited diseases, these hold promise addressing various genetically driven disorders caused by single nucleotide variants (SNVs). The precise programmability of base editors (BEs) sequences allows customization rare genetic variants, tailoring them to individual patients within affordability and delivery constraints. Cancer stems from accumulation...
Abstract Background: Chordoma is a rare bone tumor with high recurrence partially due to incomplete resection. Recent studies suggest that chordoma heterogeneous disease may comprise of molecular subtypes manifesting distinct clinical outcomes. Molecular classification improve our knowledge biology and patient stratification. However, its rareness, profiling data limited. The aim this study was identify management using methylation data. Methods: Genomic DNA extracted from fresh frozen...
Abstract Cellular senescence increases with age and contributes to age-related declines pathologies. We identified circulating biomarkers of associated diverse clinical traits in humans facilitate future non-invasive assessment individual burden efficacy testing novel senotherapeutics. Using a nanoparticle-based proteomic workflow, we profiled the senescence-associated secretory phenotype (SASP) monocytes examined these proteins plasma samples (N = 1060) from Baltimore Longitudinal Study...
<title>Abstract</title> Cellular senescence increases with age and contributes to age-related declines pathologies. We identified circulating biomarkers of associated diverse clinical traits in humans facilitate future non-invasive assessment individual burden efficacy testing novel senotherapeutics. Using a nanoparticle-based proteomic workflow, we profiled the senescence-associated secretory phenotype (SASP) monocytes examined these proteins plasma samples (N = 1060) from Baltimore...
Abstract Background Cerebral small vessel disease (cSVD), as defined by neuroimaging characteristics such white matter hyperintensities (WMHs), cerebral microhemorrhages (CMHs), and lacunar infarcts, is highly prevalent has been associated with dementia risk other clinical sequelae. Although factors for cSVD have identified, little known about the biological processes molecular mediators that influence development progression. Methods Within Atherosclerosis Risk in Communities (ARIC) study,...
Abstract Base editing (BE) techniques offer efficient means to modify specific nucleotides in the genome. While current research mainly focuses on applying BE for treating genetic diseases caused by single-nucleotide variants (SNVs), its potential cancer is worth exploring, as many tumors arise from an accumulation of various mutations. primarily consist a fusion between Cas nuclease and deaminase (Cas-BE), that enables A-to-G or C-to-T edits. This allows correction G&gt;A T&gt;C...
Abstract Background Prior infections can modify the risk for dementia and neurodegenerative disease, yet mechanisms by which contribute to neurodegeneration remain unclear. Method We examined how infection diagnoses documented in Baltimore Longitudinal Study of Aging (BLSA) are associated with rates change brain volumes over time, these same relate using hospital records from UK Biobank a Finnish multicohort sample (the Public Sector study, Health Social Support Still Working study). After...
<h3>Objective:</h3> Determine whether proteomic indicators of peripheral (non-neurologic) health are associated with change in cognition and brain volume. <h3>Background:</h3> Numerous diseases have been health. Changes the plasma proteome related to physical disease status likely contribute cognitive structural changes. Plasma changes may therefore be leveraged study link between <h3>Design/Methods:</h3> We used samples from participants Baltimore Longitudinal Study Aging (BLSA) assess...
Although liver dysfunction has been implicated in Alzheimer’s disease (AD), it remains unknown how may influence the trajectory of brain and cognitive changes older adults. We related to longitudinal measures structure cognition Baltimore Longitudinal Study Aging. Liver was identified using ICD-9 classification codes. Brain volume were assessed serially a 3T MRI battery. Baseline AD/neurodegeneration plasma biomarkers measured. 1,008 participants (9% with history) included analysis. After...
ABSTRACT SomaScan is a high-throughput, aptamer-based proteomics assay designed for the simultaneous measurement of thousands proteins with broad range endogenous concentrations. In its most current version, 7k v4.1 capable measuring 7,288 human proteins. this work, we present an extensive technical assessment platform based on study 2,050 samples across 22 plates. Included in design were inter-plate duplicates from 102 subjects, which allowed us to characterize different normalization...
Abstract Background Prior studies suggest that peripheral health and comorbid disease can influence Alzheimer’s (AD) pathology neurodegenerative processes. However, no to date have comprehensively examined how measures of risk for non‐neurological relate biomarkers commonly used in AD research. The present study the association between 16 protein‐based indicators plasma brain amyloid‐β (Aβ) accumulation, phosphorylated tau, neurodegeneration, reactive astrogliosis. Method Plasma‐based (Aβ...
Introduction: Several studies demonstrate that cardiovascular (CV) health - even among individuals without overt CV disease is associated with brain function and may influence Alzheimer’s (AD) dementia progression. Using a proteomic score to quantify the full spectrum of health, current study examined association protein-based indicators risk CV-related mortality structure older adults. Methods: The SomaScan platform was used for plasma phenotyping in Baltimore Longitudinal Study Aging...