A5019625357- Advanced Glycation End Products research
- Telomeres, Telomerase, and Senescence
- Health, Environment, Cognitive Aging
- Genetics, Aging, and Longevity in Model Organisms
- Advanced Proteomics Techniques and Applications
- GABA and Rice Research
- Advanced biosensing and bioanalysis techniques
- Mass Spectrometry Techniques and Applications
- Alzheimer's disease research and treatments
- Diabetes Management and Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Folate and B Vitamins Research
- Circadian rhythm and melatonin
- HIV-related health complications and treatments
- Galectins and Cancer Biology
- Biosensors and Analytical Detection
- Single-cell and spatial transcriptomics
- Lipid metabolism and biosynthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Iron Metabolism and Disorders
- Glycosylation and Glycoproteins Research
- Chromium effects and bioremediation
- Cardiovascular Health and Disease Prevention
- Dietary Effects on Health
National Institute on Aging
2022-2025
National Chemical Laboratory
2013-2024
National Institutes of Health
2023
Council of Scientific and Industrial Research
2021
Academy of Scientific and Innovative Research
2017-2019
University of Leeds
2016
West Bengal University of Animal and Fishery Sciences
2007
Advanced glycation end products (AGEs) are implicated in the pathology of Alzheimer's disease (AD), as they induce neurodegeneration following interaction with receptor for AGE (RAGE). This study aimed to establish a mechanistic link between AGE-RAGE signaling and AD pathology. AGE-induced changes neuro2a proteome were monitored by SWATH-MS. Western blotting cell-based reporter assays used investigate regulated APP processing tau phosphorylation primary cortical neurons. Selected protein...
Abstract The aging process is universal, and it characterized by a progressive deterioration decrease in physiological function leading to decline on the organismal level. Nevertheless, number of genetic non-genetic interventions have been described, which successfully extend healthspan lifespan different species. Furthermore, clinical trials evaluating feasibility promote human health. goal annual Biological Sciences Section Gerontological Society America meeting was share current knowledge...
Gliomas are the most common type of malignant brain tumor, which arise from glial cells. They make up about 40% all primary tumors and around 70% tumors. can occur anywhere in central nervous system (CNS) have a poor prognosis. The average survival glioma patients is approximately 6-15 months with aspects life. In this edge, identification proteins secreted by cancer cells special interest because it may provide better understanding tumor progression early diagnosis diseases. Extracellular...
Methylglyoxal (MG) is a highly reactive dicarbonyl known to be elevated under the hyperglycemic conditions of diabetes and implicated in development diabetic complications.
Meteorin (Metrn) and Meteorin-like (Metrnl) are homologous secreted proteins involved in neural development metabolic regulation. In this study, we have performed
Adult goats (no. = 18) were supplemented with chromium (Cr, 0.5 mg/kg concentrate) for 120 days as Cr chloride and yeast complex their responses in terms of glucose tolerance serum profiles metabolites hormones measured. The fed 200 g/day the concentrate reared under a semi-intensive regimen. supplementation significantly reduced ( P 0.049) cholesterol 0.0001) levels compared same control group (calculated % change between 0 120). Serum cortisol on day was lower than < 0.05). Overall, mean...
Abstract Cellular senescence increases with age and contributes to age-related declines pathologies. We identified circulating biomarkers of associated diverse clinical traits in humans facilitate future non-invasive assessment individual burden efficacy testing novel senotherapeutics. Using a nanoparticle-based proteomic workflow, we profiled the senescence-associated secretory phenotype (SASP) monocytes examined these proteins plasma samples (N = 1060) from Baltimore Longitudinal Study...
<title>Abstract</title> Cellular senescence increases with age and contributes to age-related declines pathologies. We identified circulating biomarkers of associated diverse clinical traits in humans facilitate future non-invasive assessment individual burden efficacy testing novel senotherapeutics. Using a nanoparticle-based proteomic workflow, we profiled the senescence-associated secretory phenotype (SASP) monocytes examined these proteins plasma samples (N = 1060) from Baltimore...
Methylglyoxal (MG), a glycolytic intermediate and reactive dicarbonyl, is responsible for exacerbation of insulin resistance diabetic complication. In this study, MG-induced secretome rat muscle cells was identified relatively quantified by SWATH-MS. A total 643 proteins were in secretome, which 82 upregulated 99 downregulated more than 1.3-fold SWATH analysis. Further, secretory from the classical pathway nonclassical using SignalP SecretomeP, respectively. 180 with SignalP, 113 SecretomeP....
Introduction One of the initial steps in development cardiovascular diseases involves endothelial dysfunction (ED), wherein regulatory functions vascular endothelium are disrupted. ED can be caused by chemically-modified plasma proteins that present vivo whose levels elevated metabolites and drugs found bloodstream. Under conditions such as prolonged hyperglycemia diabetes, there glucose-modified or ‘glycated’ proteins, also known advanced glycation end-products AGEs. The interaction these...
Abstract Senescent cell accumulation drives aging and related pathologies including metabolic disorders neurodegeneration, their selective elimination is a promising therapeutic approach to treat multiple diseases of in humans. However, developing drugs eliminate senescent cells requires specific biomarkers selectively identify target these vivo. In this study, we have performed comprehensive quantitative proteomic profiling surface proteomes (surfaceomes) potential senescence biomarker...
Abstract Senescent cell accumulation is a known driver of aging and age-related pathologies. Clearance senescent cells promising approach to increase longevity reduce multiple diseases in humans. Flavonoid compounds are present fruits vegetables, which certain flavonoids (e.g., quercetin fisetin) have demonstrated senolytic, or ‘senescent-cell-killing’, activity culture mice. However, the cellular mechanism senolysis efficacy these not renal epithelial cells. Here, we combine flavonoid drug...