A5071101610- Cancer Immunotherapy and Biomarkers
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Spinal Dysraphism and Malformations
- Spinal Fractures and Fixation Techniques
- Infectious Diseases and Tuberculosis
- Fetal and Pediatric Neurological Disorders
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Head and Neck Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Anesthesia and Pain Management
- Medical Imaging and Analysis
- Clusterin in disease pathology
- Testicular diseases and treatments
Griffith University
2025
Sir Ganga Ram Hospital
2001-2024
UPMC Hillman Cancer Center
2023
Chitwan Medical College
2022-2023
College of Medical Sciences
2022-2023
University of Chicago
2017-2021
Nepal Medical College Teaching Hospital
2020
Tan Tock Seng Hospital
2013
Oak Ridge National Laboratory
2012
Louisiana State University Health Sciences Center Shreveport
2004-2006
The authors hypothesized that patients developing immune-related adverse events (irAEs) while receiving immune checkpoint inhibition (ICI) for recurrent/metastatic head and neck cancer (HNC) would have improved oncologic outcomes.Patients with HNC received ICI at 2 centers. Univariate multivariate logistic regression, Kaplan-Meier methods, Cox proportional hazards regression were used to associate the irAE status overall response rate (ORR), progression-free survival (PFS), (OS) in cohort 1...
Lemierre syndrome is an uncommon condition classically described in acute oropharyngeal infection with septic thrombophlebitis of the internal jugular vein and metastatic embolism particularly to lungs. It commonly young healthy adults isolation Fusobacterium necrophorum. We describe a case 50-year-old man newly diagnosed diabetes mellitus presenting neck abscess secondary Klebsiella pneumoniae. Our patient made good recovery appropriate antimicrobial therapy, prompt surgical drainage,...
Background/Objectives: Surgical guides have been used in a variety of dental procedures, such as implant placement to improve clinical accuracy and reduce post-operative complications. This report presents novel versatile workflow for the design fabrication “multi-purpose” fully-guided tooth- bone-supported one-piece surgical guide. Methods: Briefly, intraoral perioral anatomical features were captured by an scan cone-beam computed tomography scan. The data segmented aligned with analysis...
6014 Background: Anti-programmed death receptor-1 (PD-1) therapies are approved for recurrent/metastatic head and neck (H&N) cancer progressing on or after platinum-based chemotherapy, immune competence may modulate anti-tumor response. We hypothesized that developing immune-related adverse events (irAEs) while receiving anti-PD-1 therapy metastatic H&N would be associated with improved outcomes. Methods: 114 patients unselected PD-ligand 1 (PD-L1) status received therapy. Adverse (AEs) were...
Gliomas are the most common type of malignant brain tumor, which arise from glial cells. They make up about 40% all primary tumors and around 70% tumors. can occur anywhere in central nervous system (CNS) have a poor prognosis. The average survival glioma patients is approximately 6-15 months with aspects life. In this edge, identification proteins secreted by cancer cells special interest because it may provide better understanding tumor progression early diagnosis diseases. Extracellular...
Gliomas are the most prevalent kind of malignant and severe brain cancer. Apoptosis regulating mechanisms disturbed in gliomas, as they added forms malignancy. Understanding apoptosis other associated processes thought to be critical for understanding origins tumors designing anti-cancerous drugs treatment. The purpose this study was evaluate variation expression level several apoptotic proteins that responsible low high-grade glioma. This suggests a significant change five proteins:...
Between 1989 and 1994, 50 patients suffering from congenital atlantoaxial dislocation with either an assimilated atlas or a thin deficient posterior arch of the were treated occipitocervical fusion using technique described by Jain colleagues in 1993 few modifications. An artificial bridge created occipital bone along margin foramen magnum was fused to axis sublaminar wiring interposed strut lateral onlay grafts. Ten (20%) also underwent joint intraarticular instillation chips. In 22 (44%)...
Ventriculoperitoneal (VP) shunts are among the most frequently performed operations in management of hydrocephalus. Abdominal complications, though rare, reported to occur 5–47%. VP shunt obstruction or malfunction leads raised intracranial pressure, which requires immediate intervention. Recently we have used laparoscope manage abdominal complications two patients. The first patient had hydrocephalus secondary tubercular meningitis. She developed recurrent intraabdominal cerebrospinal fluid...
6038 Background: An elevated neutrophil-to-lymphocyte ratio (NLR) is associated with tumor-induced inflammation and poor prognosis in a variety of treatment settings. Moreover, tumor-derived myeloid growth factors (Seiwert et al. ASCO 2017) could elevate the NLR suppress cytotoxic T-cell activity anti-PD-1 efficacy. We hypothesized that high baseline will associate outcomes patients metastatic head neck (H&N) cancer receiving therapy. Methods: 114 H&N unselected for PD-ligand 1 (PD-L1)...
Background: Modified Mallampati test is a standard method of assessing the airway for predicting potentially difficult laryngoscopy and intubation. This requires patient to be in sitting position evaluation. Although applicable majority patients, evaluation may not always convenient or advisable. Objectives: To compare modified grades between supine find out their corelation Cormack Lehane grade. Materials: prospective study was conducted 215, ASA I II patients undergoing various routine...
e18061 Background: Cetuximab, a monoclonal antibody against EGFR, is the only approved targeted therapy for head and neck squamous cell carcinoma (HNSCC), with single agent response rate of 13%. Patients (Pt) who respond to Cetuximab eventually develop resistance. In present study we case report deep, sustained cetuximab, followed by development acquired resistance, which was overcome different EGFR antibody. Here first known resistance mutation HNSCC provide mechanistic validation. Methods:...
Background: We report the clinical presentation, radiographic studies, intraoperative findings, histopathological analysis, and post-treatment outcome in 26 patients diagnosed with spinal synovial cysts (SSCs). Aims: To describe operative postoperative follow-up SSCs. Settings Design: The study was retrospective design, involving chart review. Individual patient data tabulated patterns were recognized. Materials Methods: charts for who underwent surgical extirpation of SSC between April 1993...
This anatomic study evaluated the extent that a fronto-orbital osteotomy (FOO) added to bilateral frontal craniotomy widened exposure midline compartment of anterior, middle, and posterior cranial fossae. The goal was determine if would significantly increase angles for two targets: foramen magnum (FM) anterior clinoid process (ACP). Stepwise dissections were performed on five cadaveric heads. A made, followed by FOO. After ethmoids removed, planum sphenoidale drilled enter sphenoid sinus....
8557 Background: PD-L1 expression and the Interferon-Gamma gene profile (IFN-G GEP) are predictive of response to checkpoint blockade in several solid tumors. Relevant biomarkers mm pts treated with these agents have not been determined; were evaluated a phase 2 trial P (NCT02399371). Methods: Eligible had histologically confirmed MM, PS 0-1, disease progression on 1-2 prior regimens. 200 mg was given Q21 days. Part A (N = 35) determined rate (RR) unselected assessed an optimal threshold...
6049 Background: PD-1 checkpoint blockade is active in head and neck squamous cell carcinomas (HNC) with a response rate of ~18% significant impact on survival. However, only subset patients benefits (Seiwert, Lancet Oncol). Biomarkers such as PD-L1 IHC the Interferon-Gamma gene expression profile (INF-G GEP) identify inflamed tumors higher chance (~35-40%). it remains unclear why majority INF-G still do not respond, or how to overcome constitutive resistance. Methods: 50 anti-PD-1 treated...
Meningioma is the second most common type of intracranial brain tumor. Immunohistochemical techniques have shown prodigious results in role epidermal growth factor receptor variant III (EGFR vIII) glioma and other cancers. However, EGFR vIII meningioma still question. This study attempt confer searches for position attained by progression expression meningioma. Immunohistochemistry technique showed that highly expressed benign tumors as compared to atypical with a significant p-value...