A5022155048- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Cardiac Arrhythmias and Treatments
- Muscle Physiology and Disorders
- Emergency and Acute Care Studies
- Diabetes Management and Research
- Cardiomyopathy and Myosin Studies
- Childhood Cancer Survivors' Quality of Life
- Viral Infections and Immunology Research
- Respiratory Support and Mechanisms
- Pregnancy and Medication Impact
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Adverse Reactions
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Healthcare Decision-Making and Restraints
- Cardiovascular Issues in Pregnancy
University of Utah
2020-2025
Primary Children's Hospital
2020-2025
Cincinnati Children's Hospital Medical Center
2017-2023
Children's Medical Center
2023
University of Cincinnati
2023
Phoenix Children's Hospital
2018-2021
Children's National
2014-2017
Stanford University
2013
Lucile Packard Children's Hospital
2013
Handheld echocardiography (HAND) has good sensitivity and specificity for rheumatic heart disease (RHD) when performed by cardiologists. However, physician shortages in RHD-endemic areas demand less-skilled users to make RHD screening practical. We examine nurse performance interpretation of HAND using a simplified approach screening.Two nurses received training on approach. Consented students at two schools Uganda were eligible participation. A (HAND interpreted non-expert) was compared...
There is significant interest in NO pathway modulators, specifically type 5 phosphodiesterase inhibitors (PDE5is), to treat patients with a Fontan circulation. Trials, however, have had mixed results. The relationship between the and clinical status circulation knowledge gap. We performed targeted metabolomic analysis using liquid chromatography coupled mass spectrometry quantify plasma metabolite concentrations from 2 well-characterized populations of circulation: Boston Adult Congenital...
Abstract Paediatric ventricular assist device patients, including those with single ventricle anatomy, are increasingly managed outside of the ICU. We used retrospective chart review our centre experience to quantify adverse event rates and ICU readmissions for 22 complex paediatric patients on support (15 two ventricles, 7 ventricle) after floor transfer. The median age was 1.65 years. majority utilised Berlin EXCOR (17, 77.3%). There were 9 length stay 2 days. Adverse events noted in...
Ventricular assist device (VAD) options vary for children in different weight groups. This study evaluates contemporary usage and outcomes based on weight. Data from the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) registry were examined patients with dilated cardiomyopathy (DCM) 4 cohorts: <8 kg, 8-20 21-40 >40 devices implanted 3/2013-10/2020. Adverse event rates ultimate outcome (deceased, alive device, transplanted, or ventricular recovery) analyzed. 222 DCM identified...
Ventricular assist device (VAD) use for failed stage II palliation (S2P) is increasing with limited data on outcomes. To address this knowledge gap, we conducted a multicenter retrospective review of the Advanced Cardiac Therapies Improving Outcomes Network registry. We leveraged registry to analyze clinical course, complications, and survival systemic VADs (SVAD) after S2P. identified 34 patients from 15 centers between 2012 2022 implanted at median age 1.8 years [interquartile range (IQR)...
Abstract Pediatric heart transplant patients face the highest waitlist mortality in solid organ transplantation. Given relatively fixed number of donor organs becoming available each year, improving utilization could potentially have significant impact on reducing mortality. Donor to recipient weight ratio has historically been used identify suitable donors; however, this method does not take into account potential for variance size due complex congenital disease or underlying...
Abstract Background Identification of patients with latent rheumatic heart disease by echocardiography presents a unique opportunity to prevent progression. Myocardial strain is more sensitive indicator cardiac performance than traditional measures systolic function. Objective The objective this study was test the hypothesis that abnormalities in myocardial may be present children disease. Methods Standard images electrocardiogram gating were obtained from Ugandan found have as well control...
Abstract Introduction Rheumatic heart disease causes substantial morbidity in children low-income countries. School-based echocardiographic screening has been suggested as a means to identify with latent disease; however, little is known about the experience of and teachers participating screenings. The aim our study was assess students’ teachers’ school-based areas for improvement. Materials methods A programme conducted five schools Northern Uganda 2013. After 8 months, an age-...
Abstract Background There are conflicting data regarding the relationship between center volume and outcomes in pediatric heart transplantation. Previous studies have not fully accounted for differences case mix, particularly high‐risk congenital disease (CHD) groups. We aimed to evaluate using Pediatric Heart Transplant Society (PHTS) Registry explore how mix may affect outcomes. Methods A retrospective cohort study of all patients PHTS who received a transplant from 2009 2018 was...
Introduction: Fontan circulatory failure (FCF) is associated with poor long-term survival. The impact of Fontan-specific morbidities on outcomes in those evaluated for heart transplant (HT) are not well understood. Hypothesis: FCF-specific morbidities, their degree severity, and the accumulation mortality individuals undergoing HT. Methods: This 20 center, retrospective cohort study FCF from 2008-2023 collected data waitlist (WL), post-HT outcomes. Each unique morbidity was defined graded...
Abstract Background Fontan circulatory failure (FCF) is a chronic state in palliated single ventricle heart disease with high morbidity and mortality including failure, multisystem end-organ disease, need for transplant. Specific FCF morbidities have not been rigorously defined, limiting study of how impact pre- post-HT outcomes. We hypothesized that FCF-related affect survival from transplant waitlisting through 1-year post-heart Methods This 20-center, retrospective cohort collected...