A5016931055- Renal and related cancers
- Renal cell carcinoma treatment
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Ethics and Legal Issues in Pediatric Healthcare
- Bone Tumor Diagnosis and Treatments
- Pediatric Urology and Nephrology Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Childhood Cancer Survivors' Quality of Life
- Urological Disorders and Treatments
- Tumors and Oncological Cases
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Glioma Diagnosis and Treatment
- Liver Disease and Transplantation
- Soft tissue tumor case studies
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Musculoskeletal synovial abnormalities and treatments
- Fungal Infections and Studies
- Congenital Anomalies and Fetal Surgery
- Medical Imaging and Pathology Studies
Children's Healthcare of Atlanta
2021-2025
Emory University
2021-2025
Vardhman Mahavir Medical College & Safdarjung Hospital
2019-2025
Safdarjang Hospital
2011-2024
Cincinnati Children's Hospital Medical Center
2017-2024
Children's Hospital of Philadelphia
2024
Nationwide Children's Hospital
2022-2024
Mayo Clinic
2024
Children's Hospital of Pittsburgh
2022-2024
University of Pennsylvania
2024
The Children's Oncology Group study AREN0534 aimed to improve event-free survival (EFS) and overall (OS) while preserving renal tissue by intensifying preoperative chemotherapy, completing definitive surgery 12 weeks from diagnosis, modifying postoperative chemotherapy based on histologic response.
Purpose This analysis of patients in the Children's Oncology Group A3973 study evaluated impact extent primary tumor resection on local progression and survival assessed concordance between clinical central imaging review-based assessments extent. Patients Methods The analytic cohort (n = 220) included who had both surgery review site. For this analysis, categories < 90% ≥ were used, with data derived from operating surgeons' (all patients), as well blinded computed tomography scans for a...
Purpose The National Wilms Tumor Study (NWTS) treatment of favorable histology tumor with lung metastases was vincristine/dactinomycin/doxorubicin (DD4A) and radiation therapy (RT). AREN0533 study applied a new risk stratification strategy to improve event-free survival (EFS) while reducing exposure RT. Methods Patients isolated showing complete nodule response (CR) after 6 weeks DD4A continued receiving chemotherapy without incomplete (IR) or loss heterozygosity at chromosomes 1p/16q...
BACKGROUND The current study was conducted to characterize the epidemiology, histology, and radiographic features of as well surgical approach pediatric adolescent renal cell carcinoma (pRCC). METHODS pRCC cases prospectively enrolled on Children's Oncology Group AREN03B2 underwent central pathology, radiology, surgery, oncology review. RESULTS As June 2012, 120 a total 3250 patients (3.7%) were found have unilateral RCC (median age, 12.9 years [range, 1.9‐22.1 years]; 52.5% female). Central...
Background The National Wilms Tumor Study (NWTS) approach to treating stage III favorable-histology tumor (FHWT) is Regimen DD4A (vincristine, dactinomycin, and doxorubicin) radiation therapy. Further risk stratification required improve outcomes reduce late effects. We evaluated clinical biologic variables for patients with FHWT without combined loss of heterozygosity (LOH) at chromosomes 1p 16q treated in the Children’s Oncology Group protocol AREN0532. Methods From October 2006 August...
To determine if observation alone after nephrectomy in very low-risk Wilms tumor (defined as stage I favorable histology tumors with weight <550g and age at diagnosis <2 years) results satisfactory event-free survival overall survival, to correlate relapse biomarkers.The AREN0532 study enrolled patients confirmed by central review of pathology, diagnostic imaging, surgical reports. After nephrectomy, were followed without adjuvant chemotherapy. Evaluable analyzed for WT1mutation, 1p 16q copy...
BACKGROUND Renal cell carcinomas (RCCs) are rare in young patients. Knowledge of their pathologic and molecular spectrum remains limited, no prospective studies have been performed to date this population. This study analyzes patients diagnosed with RCC who were prospectively enrolled the AREN03B2 Children's Oncology Group (COG). The objective was classify these tumors aid focused genetic testing characterize features. METHODS All registered as by central review retrospectively re‐reviewed...
AREN0321 evaluated the activity of vincristine and irinotecan (VI) in patients with newly diagnosed diffuse anaplastic Wilms tumor (DAWT) whether a regimen containing carboplatin (regimen UH1) addition to I agents used National Tumor Study 5 (NWTS-5; vincristine, doxorubicin, cyclophosphamide, etoposide plus radiotherapy) would improve patient outcomes.Patients stage II IV DAWT without measurable disease received UH1. Patients were eligible receive VI (vincristine, 1.5 mg/m2 per day...
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases characterized by synovial inflammation and the most common rheumatic complaint in children. To facilitate research treatment, JIA has been further classified on basis number joints involved, additional symptoms, family history, serologic findings. Imaging patients with historically relied radiography, which allows accurate assessment chronic changes JIA, including growth disturbances, periostitis, joint malalignment....
Appropriate imaging is imperative in evaluating children with a primary hepatic malignancy such as hepatoblastoma or hepatocellular carcinoma. For use the adult patient population, American College of Radiology created Liver Imaging Reporting and Data System (LI-RADS) to provide consistent terminology improve interpretation. At present, no similar consensus exists guide interpretation pediatric patients at risk for developing liver neoplasm how best evaluate known neoplasm. Therefore, new...
Background A primary objective of Children's Oncology Group study AREN0534 (Treatment for Patients With Multicentric or Bilaterally Predisposed, Unilateral Wilms Tumor) was to facilitate partial nephrectomy in 25% children with bilaterally predisposed unilateral tumors (Wilms tumor/aniridia/genitourinary anomalies/range developmental delays [WAGR] syndrome; and multifocal overgrowth syndromes). The purpose this prospective achieve excellent event‐free survival (EFS) overall (OS) while...
Abstract Background Pre‐operative assessment of intravascular extension Wilms tumor is essential to guide management. Our aim evaluate the diagnostic performance multidetector CT in detection thrombus tumor. Procedure The study population was drawn from first 1,015 cases AREN03B2 Children's Oncology Group. scans children with (n = 62) and without 111) at nephrectomy were independently reviewed by two radiologists, blinded patient information. Doppler sonography results obtained institutional...
The purpose of this study was to conduct a phase I trial <sup>90</sup>Y-DOTATOC determine the dose-toxicity profile in children and young adults with somatostatin receptor–positive tumors. <b>Methods:</b> A 3 × design used highest tolerable dose <sup>90</sup>Y-DOTATOC, administered activities 1.11, 1.48, 1.85 GBq/m<sup>2</sup>/cycle given cycles at 6-wk intervals. An amino acid infusion coadministered radiopharmaceutical for renal protection. Eligibility criteria included an age 2–25 y,...
To retrospectively determine the diagnostic performance of computed tomography (CT) in identifying presence or absence preoperative Wilms tumor rupture.The cohort was derived from AREN03B2 study Children's Oncology Group. The approved by institutional review board and compliant with HIPAA. Written informed consent obtained before enrollment. diagnosis rupture established central notes surgery and/or pathologic examination. Seventy cases were matched to 70 controls without according age...
To compare whole-body magnetic resonance (MR) imaging with conventional for detection of distant metastases in pediatric patients common malignant tumors.This institutional review board-approved, HIPAA-compliant, multicenter prospective cohort study included 188 (109 male, 79 female; mean age, 10.2 years; range, < 1 to 21 years) newly diagnosed lymphoma, neuroblastoma, or soft-tissue sarcoma. Informed consent was obtained and all underwent noncontrast material-enhanced MR standard-practice...
LBA3 Background: ASCT improves event-free survival (EFS) for HR-NB. Pilot studies suggest that intensification of myeloablative therapy using tandem further outcome We conducted a multicenter RCT comparing vs. single consolidation in patients with Methods: Between 11/2007 and 2/2012, 652 eligible (pts) newly diagnosed HR-NB received induction therapy: 6 cycles chemotherapy including initial 2 dose-intensive cyclophosphamide/topotecan followed by PBSC collection. Randomization occurred at end...
Abstract Background The purpose of this study was to evaluate the frequency and characteristics surgical protocol violations (SPVs) among children undergoing surgery for renal tumors who were enrolled on Children's Oncology Group (COG) tumor biology classification AREN03B2. Methods AREN03B2 opened in February 2006, as March 31, 2013, there 3,664 eligible patients. review forms 3,536 patients with unilateral disease centrally reviewed SPVs. frequency, type, number violations, institutional...