A5061496922- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Hepatitis C virus research
- Microscopic Colitis
- Gastrointestinal Tumor Research and Treatment
- Palliative Care and End-of-Life Issues
- Pancreatitis Pathology and Treatment
- Clostridium difficile and Clostridium perfringens research
- Iron Metabolism and Disorders
- Neurofibromatosis and Schwannoma Cases
- Geriatric Care and Nursing Homes
- Bacterial Identification and Susceptibility Testing
- Mobile Health and mHealth Applications
- Radiomics and Machine Learning in Medical Imaging
- Celiac Disease Research and Management
- Transplantation: Methods and Outcomes
- Antifungal resistance and susceptibility
- Biliary and Gastrointestinal Fistulas
- Blood donation and transfusion practices
Brigham and Women's Hospital
2018-2024
Harvard University
2019-2024
Icahn School of Medicine at Mount Sinai
2021
Yale University
2016-2019
VA Connecticut Healthcare System
2016
Universität Hamburg
1979
Abstract Background and Aims Consensus guidelines recommend high‐dose corticosteroids (1–2 mg/kg/day methylprednisolone equivalents) for treating grade ≥3 immune checkpoint inhibitor (ICI) hepatitis. We examined the effect of corticosteroid dosing on time to alanine aminotransferase (ALT) normalization, need additional immunosuppression, steroid‐related complications. Approach Results conducted a retrospective cohort study 215 ICI‐treated patients from 2010 2020 who developed (ALT > 200...
Background In the current study, authors assessed risks and outcomes of immune checkpoint inhibitor (ICI) rechallenge in patients with resolved grade 3 to 4 ICI hepatitis because guidelines recommend permanent discontinuation these patients. Methods The performed a retrospective cohort study from 2010 through 2019 melanoma who were treated ≥1 ICIs recovered hepatitis. primary outcome was recurrence secondary development any immune‐related adverse event (irAE) requiring rechallenge. Best...
The utility of liver biopsy in diagnosis
Gastrointestinal immune-related adverse events are frequently caused by immune checkpoint inhibitors (ICIs) and often require interruption of cancer treatment. Compared with ICI colitis enteritis, limited information exists about gastritis. This study characterized clinical features treatment outcomes gastritis.Consecutive patients who received ICIs underwent endoscopy gastric biopsies while on from 2011 to 2021 were retrospectively assessed. Specific histopathologic identified gastritis.Of...
Background: We evaluated the impact of gastroenterology/hepatology consultation, as recommended by guidelines, on management severe immune checkpoint inhibitor (ICI)–induced hepatitis. Methods: conducted a multicenter, retrospective cohort study 294 patients who developed grade ≥3 (alanine aminotransferase [ALT] >200 U/L) ICI-induced hepatitis, with early consultation defined occurring within 7 days diagnosis. The primary outcome was time to ALT normalization (≤40 U/L), and secondary...
Background: Patients with end-stage liver disease (ESLD) have high mortality, but low utilization of palliative care. A transitional care clinic (TCLC), bridging inpatient hepatology to outpatient clinics, should offer the ideal setting for advance planning (ACP). Objective: To examine ACP and related outcomes TCLC patients who died within one year initial visit. Design: Retrospective chart review. Setting: Nontransplant eligible ESLD patients, seen in postdischarge from an unit....
Immune checkpoint inhibitor-induced pancreatic injury (ICI-PI) ranges from asymptomatic hyperlipasemia to symptomatic acute pancreatitis (AP). The proportion of while receiving ICIs that is attributable therapy remains unclear. We evaluated the etiology in patients ICIs, and clinical characteristics, management, outcomes ICI-PI.We assessed 6,450 consecutive adult with cancer who received ICI doses between 2011 2019, 364 whom had at least 1 instance elevated serum lipase after initiation were...
We aimed to develop a predictive model of disease severity for cirrhosis using MRI-derived radiomic features the liver and spleen compared it existing metrics MELD score clinical decompensation. The is compiled solely by blood parameters, so far, was not investigated if extracted image-based have potential reflect potentially complement calculated score.This retrospective study eligible patients with ([Formula: see text]) who underwent contrast-enhanced MR screening protocol hepatocellular...
Infections in patients with cirrhosis are common among those who develop variceal hemorrhage. Prophylactic antimicrobial treatment third generation cephalosporins is recommended advanced and gastrointestinal However no infectious source identified up to 50% of clinical sepsis. We report the first case Paracoccus yeeii bacteremia a patient decompensated presented This rare gram negative organism that occurs naturally soil has been difficult isolate until recent technological advances may not...
1Department of Internal MedicineYale University School MedicineNew HavenCT 2Section Digestive DiseasesYale 3Section DiseasesVA‐CT Healthcare SystemWest *ADDRESS CORRESPONDENCE AND REPRINT REQUESTS TO:Guadalupe Garcia‐Tsao, M.D.Section Medicine333 Cedar Street1080 LMPP.O. Box 208019New Haven, CT 06520‐8019E‐mail: [email protected]
Despite scant evidence, current guidelines indicate that esophageal varices are a relative contraindication to transesophageal echocardiography (TEE). The aim of this study is compare the risk gastrointestinal bleeding following TEE among cirrhotic patients with and without endoscopically-documented varices. This retrospective analysis cirrhosis who underwent upper endoscopy within 4 years at five institutions between January 2000 March 2020. Primary outcome was overt bleeding. Secondary...
Radiomics extracts quantitative image features to identify biomarkers for characterizing disease. Our aim was characterize the ability of radiomic extracted from magnetic resonance (MR) imaging liver and spleen detect cirrhosis by comparing patients with those without cirrhosis.This retrospective study compared MR-derived between undergoing hepatocellular carcinoma screening intraductal papillary mucinous neoplasm surveillance 2015 2018 using same protocol. Secondary analyses stratified...
Patients of Jehovah's Witnesses faith who are in need liver transplantation pose unique challenges. These patients should be seen at transplant centers with experience caring for to formulate careful preoperative, intraoperative, and postoperative strategies on an individualized basis multidisciplinary input mitigate the risk bleeding complications prepare potentially catastrophic scenarios. In-depth conversations about what constitutes acceptable bloodless transfusion both patient center...