A5100724524- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Liver Diseases and Immunity
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Liver Disease and Transplantation
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Hepatitis C virus research
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Neonatal Health and Biochemistry
- COVID-19 and healthcare impacts
- Opioid Use Disorder Treatment
- Pharmaceutical Practices and Patient Outcomes
- Neuroendocrine Tumor Research Advances
- Substance Abuse Treatment and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Lipids, and Metabolism
University of California, San Francisco
2021-2024
University of California San Francisco Medical Center
2024
Promega (United States)
2024
Peter MacCallum Cancer Centre
2022
Brigham and Women's Hospital
2020-2021
Harvard University
2020-2021
Smith-Kettlewell Eye Research Institute
2020
Massachusetts Eye and Ear Infirmary
2020
University of Oklahoma Health Sciences Center
2020
McMaster University
2020
Large language models (LLMs) hold tremendous potential for accelerating clinical research and augmenting care. One of the most promising LLM use cases is natural processing (NLP) extraction elements from unstructured text, which LLMs may be superior to existing NLP software packages.1Singhal K. et al.Nature. 2023; 620: 172-180Crossref PubMed Scopus (188) Google Scholar,2Bhattarai al.bioRxiv.[Preprint, September 29. https://doi.org/10.1101/2023.09.27.559788Crossref (0) Scholar Due its...
Abstract Background LIV-1, a transmembrane protein and downstream target of STAT3, is highly expressed in breast cancer cells. It associated with lymph node involvement metastatic progression. SGN-LIV1A an anti-LIV-1 antibody conjugated via protease-cleavable linker to monomethyl auristatin E (MMAE). Upon binding cell-surface internalized releases MMAE, which disrupts microtubulin induces apoptosis. Methods This ongoing, phase 1 study evaluates safety, tolerability, pharmacokinetics,...
Abstract Background and Aims Consensus guidelines recommend high‐dose corticosteroids (1–2 mg/kg/day methylprednisolone equivalents) for treating grade ≥3 immune checkpoint inhibitor (ICI) hepatitis. We examined the effect of corticosteroid dosing on time to alanine aminotransferase (ALT) normalization, need additional immunosuppression, steroid‐related complications. Approach Results conducted a retrospective cohort study 215 ICI‐treated patients from 2010 2020 who developed (ALT > 200...
Large language models (LLMs) have proven useful for extracting data from publicly available sources, but their uses in clinical settings and with are unknown.
The chick chorioallantoic membrane (CAM) begins to develop by day 7 after fertilization and matures 12. CAM is naturally immunodeficient highly vascularized, making it an ideal system for tumor implantation. Furthermore, the contains extracellular matrix proteins such as fibronectin, laminin, collagen, integrin alpha(v)beta3, MMP-2, attractive model study invasion metastasis. Scientists have long taken advantage of physiology using a angiogenesis. More recently, assay has been modified work...
Background In the current study, authors assessed risks and outcomes of immune checkpoint inhibitor (ICI) rechallenge in patients with resolved grade 3 to 4 ICI hepatitis because guidelines recommend permanent discontinuation these patients. Methods The performed a retrospective cohort study from 2010 through 2019 melanoma who were treated ≥1 ICIs recovered hepatitis. primary outcome was recurrence secondary development any immune‐related adverse event (irAE) requiring rechallenge. Best...
552 Background: HIMALAYA showed that D+T and D are effective options for unresectable hepatocellular carcinoma (uHCC). However, data on outcomes according to the adherence inclusion criteria in routine clinical practice lacking. Methods: In context of a prospectively maintained database including 1293 patients (pts) with uHCC treated immunotherapy, we analysed pts or across 8 centres USA, Asia Europe. Pts who met >1 key exclusion criterion (prior systemic therapy, Child-Pugh class B-C,...
540 Background: Hepatocellular carcinoma (HCC) is a cancer with poor prognosis and rising incidence. The combination of atezolizumab plus bevacizumab (A+B) prolongs survival as 1 st line therapy in advanced HCC (aHCC) but confers rare risk serious bleeding. brain metastases (BM) have high hemorrhage rates contraindicate the A+B regimen. Alternative immunotherapies also prolong without increased bleeding risk. We conducted retrospective review large, diverse, center registry to estimate...
Chemoresistance cells have features similar to cancer stem cells. Elimination of these is an effective therapeutic strategy clinically combat chemoresistance non-small cell lung (NSCLC). Here, we demonstrate that Doublecortin-like kinase1 (DCLK1) the key developing and associated stemness in NSCLC. DCLK1 highly expressed human adenocarcinoma strongly correlated with stemness. Silencing inhibits NSCLC primary secondary spheroid formation, which prerequisite feature tumor inhibition reduced...
The utility of liver biopsy in diagnosis
Rituximab is a monoclonal anti-CD20 antibody that standard of care for treatment B-cell non-Hodgkin lymphoma (NHL). The purpose this study was to quantify the incidence rituximab (R)-related interstitial pneumonitis (IP) in patients with NHL receiving immunochemotherapy. All who received cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), (CVP), R-CHOP or R-CVP Princess Margaret Hospital between June 1998 August 2009 were retrospectively reviewed. We compared cohorts did not...
Background: We evaluated the impact of gastroenterology/hepatology consultation, as recommended by guidelines, on management severe immune checkpoint inhibitor (ICI)–induced hepatitis. Methods: conducted a multicenter, retrospective cohort study 294 patients who developed grade ≥3 (alanine aminotransferase [ALT] >200 U/L) ICI-induced hepatitis, with early consultation defined occurring within 7 days diagnosis. The primary outcome was time to ALT normalization (≤40 U/L), and secondary...
Summary Background Immune checkpoint inhibitors (ICIs) are effective oncologic agents which frequently cause immune‐related adverse events (irAEs) can impact multiple organ systems. Onco‐Gastroenterology is a novel and emerging subspecialty within gastroenterology focused on cancer treatment‐related complications. Gastroenterologists must be prepared to identify manage diverse immune‐mediated toxicities including enterocolitis, hepatitis, pancreatitis other ICI‐induced toxicities. Aim To...
BACKGROUND: Serum bilirubin is inversely associated with cardiovascular risk. Atazanavir, an HIV protease inhibitor that competitively inhibits conjugation, provides a unique opportunity to examine whether selectively increasing cardioprotective. We sought determine patients receiving atazanavir manifest reduced risk of disease compared those darunavir, does not increase serum bilirubin. METHODS AND RESULTS: This was retrospective cohort study 1020 HIV. The main outcome time myocardial...
Preoperative risk stratification is used to derive an optimal treatment plan for patients requiring cancer surgery. Patients with reversible factors are candidates prehabilitation programmes. This pilot study explores the impact of preoperative covariates comorbid disease (Charlson Co-morbidity Index), serum biomarkers, and traditional cardiopulmonary exercise testing (CPET)-derived parameters functional capacity on postoperative outcomes after major colorectal surgery.Consecutive who...
To determine the effect of povidone iodine (PI), an antiseptic commonly used prior to ocular surgery, on viability mixed populations conjunctival stratified squamous and goblet cells, purified cells stromal fibroblasts in primary culture.Mixed population epithelial (stratified cells), were grown culture from pieces human conjunctiva using either supplemented DMEM/F12 or RPMI. Cell type was evaluated by immunofluorescence microscopy. Cells treated for 5 min with phosphate-buffered saline...
The human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase and tumor-associated antigen abnormally expressed in various types of cancer, including breast, ovarian, gastric cancer. HER2 overexpression highly correlated with increased tumor aggressiveness, poorer prognosis, shorter overall survival. Consequently, multiple HER2-targeted therapies have been developed approved; however, only subset patients benefit from these treatments, relapses are common. More...
Spine surgery rates have increased and the high postoperative morbidity in these patients result costs. Consequently, it is essential to identify at risk of adverse outcomes.To assess whether preoperative Timed Up Go (TUG) test performance can predict high-grade complications.A prospective cohort study undergoing elective thoracolumbar spine a tertiary care hospital between 2017 2018. Patients were assessed preoperatively assigned slow-TUG group if unable perform or time was ≥18.4 s. Primary...
Despite scant evidence, current guidelines indicate that esophageal varices are a relative contraindication to transesophageal echocardiography (TEE). The aim of this study is compare the risk gastrointestinal bleeding following TEE among cirrhotic patients with and without endoscopically-documented varices. This retrospective analysis cirrhosis who underwent upper endoscopy within 4 years at five institutions between January 2000 March 2020. Primary outcome was overt bleeding. Secondary...