A5102006032- interferon and immune responses
- RNA regulation and disease
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Vector-Borne Animal Diseases
- Plant Parasitism and Resistance
- Biological Control of Invasive Species
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Plant and Fungal Species Descriptions
- Congenital Anomalies and Fetal Surgery
- Inflammasome and immune disorders
- Animal Virus Infections Studies
- Prenatal Screening and Diagnostics
- Parvovirus B19 Infection Studies
- Virus-based gene therapy research
- Genital Health and Disease
- COVID-19 diagnosis using AI
- Traditional Chinese Medicine Studies
- T-cell and Retrovirus Studies
- Seaweed-derived Bioactive Compounds
- Polyomavirus and related diseases
- Advanced optical system design
- NF-κB Signaling Pathways
Promega (United States)
2023-2024
Anhui Medical University
2024
University of Connecticut
2022-2023
Harbin Veterinary Research Institute
2015-2023
Chinese Academy of Agricultural Sciences
2013-2023
Hunan Agricultural University
2023
Shandong Academy of Sciences
2023
Qilu University of Technology
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020
Chongqing Medical University
2020
Inflammatory factors and type I interferons (IFNs) are key components of host antiviral innate immune responses, which can be released from the pathogen-infected macrophages. African swine fever virus (ASFV) has developed various strategies to evade including alteration inflammatory responses IFNs production. However, molecular mechanism underlying inhibition production by ASFV-encoded proteins not been fully understood. Here we report that ASFV infection only induced low levels IL-1β in...
Abstract African swine fever is a severe animal infectious disease caused by virus (ASFV), and the morbidity mortality associated with virulent ASFV isolates are as high 100%. Previous studies showed that ability of to antagonize IFN production closely related its pathogenicity. Here, we report HLJ/18 infection induced low levels type I inhibited cGMP-AMP–induced in porcine alveolar macrophages were isolated from specific pathogen-free Landrace piglets. Subsequently, an unbiased screen was...
African swine fever (ASF) is a highly contagious infectious disease of domestic pigs and wild boars caused by virus (ASFV), with mortality rate up to 100%. In order replicate efficiently in macrophages monocytes, ASFV has evolved multiple strategies evade host antiviral responses. However, the underlying molecular mechanisms which ASFV-encoded proteins execute immune evasion are not fully understood. this study, we found that pH240R strongly inhibits transcription, maturation, secretion...
The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting secretion of IL-1β and inflammatory pathologic responses. Viral RNA can induce activation. However, none the components has ability to bind viral RNA. Therefore, it had been proposed that there might have some unidentified cytosolic sensors could initiate In this study, DDX19A, member DEAD/H-box protein family, was identified as novel component using arterivirus infection model. We found...
Highlights•DDX19 suppresses IRF3 phosphorylation•DDX19 competes with TBK1 or IKKε binding to the IAD domain of IRF3•DDX19 recruits Lamtor2 promote and degradation•DDX19 inhibits type I IFN production thus enhances viral replicationSummaryDExD/H-box helicase members are key receptors for recognizing nucleic acids, they regulate retinoic acid-inducible gene (RIG-I)-like receptor (RLR)-mediated interferon (IFN) production. Here, we report that DExD/H-box family member RNA 19 (DDX19) is a...
The epithelial cell adhesion molecule (EpCAM) is often overexpressed in many types of tumors, including colorectal cancer. We sequenced and humanized an EpCAM mouse antibody used it to develop bispecific EpCAM-CD3 antibodies. Three different designs were generate antibodies such as CrossMab knob-in-hole, ScFv-CD3 ScFv (BITE), ScFv-human Fc designs. These showed strong specific binding the EpCAM-positive Lovo line T cells, specifically killed cells not EpCAM-negative Colo741 presence...
Type I interferon (IFN) plays an essential role in the host innate immune responses. Several ubiquitin-conjugating enzyme (E2) family members were reported to regulate type IFN production and antiviral However, molecular mechanisms are still not fully understood. Here, we report that UBE2S acts as a negative regulator signaling pathway. Ectopic expression of inhibits responses enhances viral replications, whereas deficiency suppresses replications both vitro vivo. Inhibition І by is...
TRAF family member-associated NF-κB activator (TANK) is a scaffold protein that assembles into the interferon (IFN) regulator factor 3 (IRF3)-phosphorylating TANK-binding kinase 1 (TBK1)–(IκB) ε (IKKε) complex, where it involved in regulating phosphorylation of IRF3 and IFN production. However, functions TANK encephalomyocarditis virus (EMCV) infection-induced type I production are not fully understood. Here, we demonstrated that, instead stimulating production, EMCV-HB10 strain infection...
As an initial step towards understanding the molecular mechanisms by which plants become invasive, we present here first transcriptome analysis for invasive weed Mikania micrantha. The was based on 75-nucleotide short reads data generated Illumina Genome Analyzer II system. A total of 31 131 unique sequences were assembled de novo 8.7 million filtered paired-end sequence individual M. micrantha growing in field. 73 % showed significant similarity to existing proteins NCBI database, and 21...
The human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase and tumor-associated antigen abnormally expressed in various types of cancer, including breast, ovarian, gastric cancer. HER2 overexpression highly correlated with increased tumor aggressiveness, poorer prognosis, shorter overall survival. Consequently, multiple HER2-targeted therapies have been developed approved; however, only subset patients benefit from these treatments, relapses are common. More...
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a urinary disorder that affects youthful to middle-aged men most frequently. It has been revealed Th17/Treg imbalance crucial factor in the pathophysiological mechanisms behind this disease. However, imbalance's are unknown. In experimental autoimmune prostatitis (EAP) mouse model, NLRP3 inflammasome was turned on, IL-1β levels went up. Moreover, there exists discernible positive association between upsurge and perturbation of...
We successfully constructed a full-length cDNA infectious clone of the encephalomyocarditis virus (EMCV) HB10 strain and obtained partially attenuated rEMCV-C9 with shorter poly(C) tract. Our results showed that length EMCV-HB10 tract was related to pathogenicity in vivo. Using pEMCV-C9 as backbone, we novel viral vector pC9-MCS-∆2A by inserting fragment containing 127 amino acid deletion 2A protein, primary cleavage cassette, FLAG tag multiple cloning site (MCS) at junction VP1 ∆2A....
As an initial step towards understanding the molecular mechanisms by which plants become invasive, we present here first transcriptome analysis for invasive weed Mikania micrantha. The was based on 75-nucleotide short reads data generated Illumina Genome Analyzer II system. A total of 31 131 unique sequences were assembled de novo 8.7 million filtered paired-end sequence individual M. micrantha growing in field. 73 % showed significant similarity to existing proteins NCBI database, and 21...
Abstract Objective To estimate the positive predictive value (PPV) of fetal sex chromosome aneuploidy (SCA) screened in non-selective population and explore rate pregnancy termination ultrasound findings for SCA factors influencing parents’ decisions South China. Methods This is a large-scale retrospective cohort from unselected singleton pregnancies by non-invasive prenatal testing (NIPT) single center tertiary hospital, January 2016 to November 2019. Clinical information, indications,...
Learning-based Multi-view Stereo (MVS) and stereo matching methods typically construct 3D cost volumes based on the camera frustum of reference view. Regularization regression volume are performed to obtain a depth map. However, resolution output map is limited by computational cost, when performing feature extraction, characteristics convolution local perception make it impossible capture global context information. In this paper, we propose CTPMVSNet using Global Feature Aware Transformer...