A5080746107- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Biological Control of Invasive Species
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Coastal wetland ecosystem dynamics
- Endoplasmic Reticulum Stress and Disease
- Genomics and Phylogenetic Studies
- Cancer Research and Treatments
- Ecology and Vegetation Dynamics Studies
- Plant and animal studies
- Genetic diversity and population structure
- Plant and Fungal Species Descriptions
- Plant Molecular Biology Research
- HIV/AIDS Research and Interventions
- Genomic variations and chromosomal abnormalities
- Plant Parasitism and Resistance
- Allelopathy and phytotoxic interactions
- Genetic and phenotypic traits in livestock
- Plant Gene Expression Analysis
- Diatoms and Algae Research
- Genetic Mapping and Diversity in Plants and Animals
- Plant Taxonomy and Phylogenetics
- Regulation of Appetite and Obesity
- HIV-related health complications and treatments
Guangdong Pharmaceutical University
2025
Huizhou University
2023-2024
Harvard University
2024
Northwest A&F University
2019-2024
Sun Yat-sen University
2010-2017
University of Hong Kong
2016
South China Botanical Garden
2011
Chinese Academy of Sciences
2011
Systemic inflammation will cause an imbalance in the steady state of gut–brain axis. Phosphatidylcholine (PC) is a phospholipid found egg yolk that has anti-inflammatory and antioxidant properties. The present research proved PC supplementation (60 mg/kg body weight) for 35 days prevented inflammatory responses behavioral disturbances lipopolysaccharide (LPS)-induced mice. could regulate expression neurotrophic factors synaptic proteins, which effectively alleviated nerve damage dysfunction...
Rhizophora species are the most widely distributed mangrove trees in Indo-West Pacific (IWP) region. Comparative studies of these with shared life history traits can help identify evolutionary factors that have played important roles determining genetic diversity within and between populations ocean-current dispersed tree species. We sampled 935 individuals from 54 natural for genotyping 13 microsatellite markers to investigate level variation, population structure, gene flow on a broad...
Objective: To explore the latent-classes of HIV high risk behaviors among college students, and association between experiences intimate partner violence (IPV) behaviors, to provide evidence for reducing them. Methods: A cross-sectional study was conducted from October December 2019 university students six higher education institutions in Zhuhai City, using a multi-stage cluster sampling method, with an estimated sample size 1 318. The included participants who self-reported being romantic...
Abstract Background Understanding factors associated with antiretroviral treatment (ART) adherence is crucial for ART success among people living HIV (PLHIV) in the “test and treat” era. Multiple psychosocial tend to coexist have a syndemic effect on adherence. We aimed explore of multiple PLHIV newly starting Guangdong Province, China. Methods Newly diagnosed from six cities Province were recruited between May 2018 June 2019, then followed up 2019 August 2020. Baseline follow-up data...
• Premise of the study: Microsatellite markers were developed for invasive species Mikania micrantha to investigate its invasion history. Transcriptome sequencing projects offer a potential source development new markers. Methods and Results: Sixteen polymorphic simple sequence repeat (SSR) derived from ESTs identified screened in 36 samples M. micrantha. The number alleles per locus ranged two four, with an average 2.7 locus. expected heterozygosity observed 0 0.7754 0.8333, respectively....
Abstract Biological invasions that involve well‐documented rapid adaptations to new environments provide unequalled opportunities for testing evolutionary hypotheses. Mikania micrantha Kunth (Asteraceae), a perennial herbaceous vine native tropical Central and South America, successfully invaded Asia in the early 20th century. It is regarded as one of most aggressive weeds world. To elucidate molecular processes underlying this invasion, we extensively sampled weed throughout its range...
Abstract Although persistent efforts have identified and characterized a few candidate genes related biological processes with potential functions in the adaptation of many species to extreme environments, works been conducted determine genomic basis endangered livestock breeds that living conditions for more than thousands years. To fill this gap, we sequenced whole genomes nine individuals from three Chinese native cattle are high‐altitude or arid environments. Phylogenetic evolutionary...
As an initial step towards understanding the molecular mechanisms by which plants become invasive, we present here first transcriptome analysis for invasive weed Mikania micrantha. The was based on 75-nucleotide short reads data generated Illumina Genome Analyzer II system. A total of 31 131 unique sequences were assembled de novo 8.7 million filtered paired-end sequence individual M. micrantha growing in field. 73 % showed significant similarity to existing proteins NCBI database, and 21...
Chromatin accessibility and post-transcriptional histone modifications play important roles in gene expression regulation. However, little is known about the joint effect of multiple chromatin on level plants, despite that regulatory individual marks such as H3K4me3 have been well-documented. By using machine-learning methods, we systematically performed prediction based data Arabidopsis rice. We found few four were sufficient to yield good performance, H3K36me3 being top two predictors with...
As a significant process of post-transcriptional gene expression regulation in eukaryotic cells, alternative splicing (AS) exons greatly contributes to the complexity transcriptome and indirectly enriches protein repertoires. A large number studies have focused on inclusion revealed roles AS organ development maturation. Notably, takes place through change relative abundance transcript isoforms produced by single gene, meaning that can complex patterns. However, commonly used percent...
Spartina alterniflora is one of the nine most notoriously invasive plants in China. Microsatellite markers were developed for this species to investigate its invasiveness and genetic diversity. •Fifteen polymorphic seven monomorphic simple sequence repeat (SSR) derived from expressed tags (ESTs) identified screened 60 samples S. alterniflora. The number alleles per locus ranged two eight, with an average 3.8 locus. expected heterozygosity observed based on disomic loci 0.27 0.46 0.21 0.51,...
We present TXpredict, a transformer-based framework for predicting microbial transcriptomes using annotated genome sequences. By leveraging information learned from large protein language model, TXpredict achieves an average Spearman correlation of 0.53 in gene expression new bacterial genomes. further extend this to predict 900 additional genomes spanning 276 genera, 69% which remain uncharacterized at the transcriptional level. Additionally, enables prediction condition-specific...
As an initial step towards understanding the molecular mechanisms by which plants become invasive, we present here first transcriptome analysis for invasive weed Mikania micrantha. The was based on 75-nucleotide short reads data generated Illumina Genome Analyzer II system. A total of 31 131 unique sequences were assembled de novo 8.7 million filtered paired-end sequence individual M. micrantha growing in field. 73 % showed significant similarity to existing proteins NCBI database, and 21...
In eukaryotes, the three-dimensional (3D) conformation of genome is far from random, and this nonrandom chromatin organization strongly correlated with gene expression protein function, which are two critical determinants selective constraints evolutionary rates genes. However, whether genes other elements that located close to each in 3D evolve a coordinated way has not been investigated any organism. To address question, we constructed interaction networks (CINs) Arabidopsis thaliana based...
Abstract Retrocopies are gene duplicates arising from reverse transcription of mature mRNA transcripts and their insertion back into the genome. While long being regarded as processed pseudogenes, more functional retrocopies have been discovered. How stripped- down recover expression capability become paralogs continually intrigues evolutionary biologists. Here, we investigated function evolution in context three-dimensional (3D) genome organization. By mapping retrocopy-parent pairs onto...
Retrocopies are gene duplicates arising from reverse transcription of mature mRNA transcripts and their insertion back into the genome. While long being regarded as processed pseudogenes, more functional retrocopies have been discovered. How stripped-down recover expression capability become paralogs continually intrigues evolutionary biologists. Here, we investigated function evolution in context 3D genome organization. By mapping retrocopy-parent pairs onto sequencing-based imaging-based...