A5077449133- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 and healthcare impacts
- HER2/EGFR in Cancer Research
- interferon and immune responses
- Immunotherapy and Immune Responses
- Hippo pathway signaling and YAP/TAZ
- Organ Transplantation Techniques and Outcomes
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Hepatitis C virus research
- Phagocytosis and Immune Regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Degradation and Inhibitors
- Cellular Mechanics and Interactions
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cell Adhesion Molecules Research
Stanford University
2019-2024
VA Palo Alto Health Care System
2024
Stanford Medicine
2020-2021
Pharmaceutical Product Development (United States)
2016
Abstract Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development 1,2 , and increased stiffness known promote HCC progression cirrhotic conditions 3,4 . characterized by an accumulation of advanced glycation end-products (AGEs) the ECM; however, how this affects non-cirrhotic unclear. Here we find that, patients animal models, AGEs changes collagen architecture enhance ECM...
Background and Aims Coronavirus disease 2019 (COVID‐19) is associated with liver injury, but the prevalence patterns of injury in transplantation (LT) recipients COVID‐19 are open for study. Approach Results We conducted a multicenter study United States 112 adult LT COVID‐19. Median age was 61 years (interquartile range, 20), 54.5% (n = 61) were male, 39.3% 44) Hispanic. Mortality rate 22.3% 25); 72.3% 81) hospitalized 26.8% 30) admitted to intensive care unit (ICU). Analysis peak values...
Metastasis is a major cause of cancer mortality. We generated an autochthonous transgenic mouse model whereby conditional expression MYC and Twist1 enables hepatocellular carcinoma (HCC) to metastasize in >90% mice. cooperate their sustained required elicit transcriptional program associated with the activation innate immunity, through secretion cytokinome that elicits recruitment polarization tumor macrophages (TAMs). Systemic treatment Ccl2 Il13 induced MYC-HCCs metastasize; whereas,...
Abstract Cancers evade immune surveillance, which can be reversed through immune-checkpoint therapy in a small subset of cases. Here, we report that the MYC oncogene suppresses innate surveillance and drives resistance to immunotherapy. In 33 different human cancers, genomic amplification overexpression increased expression, predicted nonresponsiveness blockade, was associated with both Th2-like profile reduced CD8 T-cell infiltration. transcriptionally suppressed immunity MHCI-mediated...
The COVID-19 pandemic forced medical schools to rapidly transform their curricula using online learning approaches. At our institution, the preclinical Practice of Medicine (POM) course was transitioned large-group, synchronous, video-conference sessions. aim this study is assess whether there were differences in learner engagement, as evidenced by student question-asking behaviors between in-person and videoconferenced sessions one course. In Spring, 2020, large-group didactic POM converted...
Antibody-drug conjugates (ADCs) require thorough characterization and understanding of product quality attributes. The framework many ADCs comprises one molecule antibody that is usually conjugated with multiple drug molecules at various locations. It unknown whether the release rate from ADC dependent on location, and/or local environment, dictated by sequence structure carrier. This study addresses these issues valine-citrulline-monomethylauristatin E (vc-MMAE)-based reduced disulfide...
S evere acute respiratory syndrome coronavirus 2 has caused more than 10 million infections in the United States, and its associated disease, disease-2019 (COVID-19), unfortunately led to 240,000 deaths. 1 There is growing recognition of significant racial disparities with COVID-19, concern that Black Hispanic individuals have a higher risk infection mortality from COVID-19. Chronic liver diseases (CLDs) are major public health burden, substantial exist both prevalence CLD States. 3ecent...
Abstract Long waiting times due to ongoing organ shortage have led increased utilization of locoregional therapies (LRTs) bridge patients with hepatocellular carcinoma (HCC) liver transplantation (LT). We performed this study evaluate the impact LRTs on post‐LT outcomes. conducted a retrospective who were transplanted for HCC at Stanford University Hospital between 2008 and 2018 ( n = 302). found that receipt ≥5 was an independent significant predictor poor overall 5‐year survival (58.3% vs....
The incidence of hepatocellular carcinoma (HCC) is growing in the United States, especially among elderly. Older patients are increasingly receiving transplants as a result HCC, but impact advancing age on long-term posttransplant outcomes not clear. To study this, we used data from US Multicenter HCC Transplant Consortium 4980 patients. We divided into 4 groups by at transplantation: 18 to 64 years (n = 4001), 65 69 683), 70 74 252), and ≥75 44). There were no differences tumor stage, type...
ABSTRACT Cancers evade immune surveillance that in some, but not many, cases can be reversed through checkpoint therapy. Here we report the MYC oncogene suppresses surveillance, activates expression, and predicts responsiveness to inhibition. First, when is genomically amplified overexpressed 33 different human cancers, this increases drives therapeutic resistance, associated with both Th2-like profile, reduced CD8 T cell infiltration. Second, experimentally, MYC-driven tumors suppress...
<div>Abstract<p>Cancers evade immune surveillance, which can be reversed through immune-checkpoint therapy in a small subset of cases. Here, we report that the MYC oncogene suppresses innate surveillance and drives resistance to immunotherapy. In 33 different human cancers, genomic amplification overexpression increased expression, predicted nonresponsiveness blockade, was associated with both Th2-like profile reduced CD8 T-cell infiltration. transcriptionally suppressed immunity...
<p>Supp Figures 1-14</p>
<p>Supp Figures 1-14</p>
<div>Abstract<p>Cancers evade immune surveillance, which can be reversed through immune-checkpoint therapy in a small subset of cases. Here, we report that the MYC oncogene suppresses innate surveillance and drives resistance to immunotherapy. In 33 different human cancers, genomic amplification overexpression increased expression, predicted nonresponsiveness blockade, was associated with both Th2-like profile reduced CD8 T-cell infiltration. transcriptionally suppressed immunity...