A5020610335- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Systemic Lupus Erythematosus Research
- Horticultural and Viticultural Research
- Veterinary Equine Medical Research
- HER2/EGFR in Cancer Research
- Lipid metabolism and disorders
- Signaling Pathways in Disease
- Protein Degradation and Inhibitors
- Mathematical Biology Tumor Growth
- Ion Transport and Channel Regulation
Aarhus University
2011-2024
Stanford University
2020-2022
Abstract The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly induction of interferon inflammatory cytokines. Here we report that cGAMP stimulation leads transient decline ER cholesterol levels, mediated Sterol O-Acyltransferase 1-dependent esterification. This facilitates membrane curvature...
The MYC oncogene drives T- and B- lymphoid malignancies, including Burkitt's lymphoma (BL) Acute Lymphoblastic Leukemia (ALL). Here, we demonstrate a systemic reduction in natural killer (NK) cell numbers SRα-tTA/Tet-O-MYCON mice bearing MYC-driven T-lymphomas. Residual mNK cells spleens of MYCON T-lymphoma-bearing exhibit perturbations the terminal NK effector differentiation pathway. Lymphoma-intrinsic arrests maturation by transcriptionally repressing STAT1/2 secretion Type I Interferons...
Abstract Cancers evade immune surveillance, which can be reversed through immune-checkpoint therapy in a small subset of cases. Here, we report that the MYC oncogene suppresses innate surveillance and drives resistance to immunotherapy. In 33 different human cancers, genomic amplification overexpression increased expression, predicted nonresponsiveness blockade, was associated with both Th2-like profile reduced CD8 T-cell infiltration. transcriptionally suppressed immunity MHCI-mediated...
Abstract A key phenomenon in cancer is the establishment of a highly immunosuppressive tumour microenvironment (TME). Despite advances immunotherapy, where purpose to induce recognition and hence hereof eradication, majority patients applicable for such treatment still fail respond. It has been suggested that high immunological activity essential achieving effective response which therefore have led exploration strategies triggers inflammatory pathways. Here activation stimulator interferon...
Extracellular vesicles (EVs) have been recognized as route of communication in the microenvironment. They transfer proteins and microRNAs (miRNAs) between cells, possess immunoregulatory properties. However, their role immune-mediated diseases remains to be elucidated. We hypothesized a for EVs rheumatoid arthritis (RA) joint, potentially involving development T cell exhaustion co-inhibitory receptor programmed death 1 (PD-1).Synovial fluid mononuclear cells (SFMCs) peripheral blood (PBMCs)...
Abstract CD46 is a glycoprotein with important functions in innate and adaptive immune responses. Functionally different isoforms are generated by alternative splicing at exons 7–9 (BC C isoforms) exon 13 (CYT-1 CYT-2 giving rise to BC1, BC2, C1 C2. We developed novel real-time PCR assay that allows quantitative comparisons between these isoforms. Their relative frequency CD4 + T cells from 100 donors revealed distribution high interpersonally variability. Importantly, the was not random...
Abstract Background Lymphocyte activation gene-3 (LAG-3) inhibits T cell and interferes with the immune response by binding to MHC-II. As antigen presentation is central in rheumatoid arthritis (RA) pathogenesis, we studied aspects of LAG-3 as a serological marker mediator pathogenesis RA. Since Galectin-3 (Gal-3) described an additional partner for LAG-3, also aimed study functional importance this interaction. Methods Plasma levels soluble (s) were measured early RA patients (eRA, n = 99)...
Active rheumatoid arthritis (RA) is accompanied by increased appendicular and axial bone loss, closely associated to the degree of inflammation. The programmed death-1 (PD-1) pathway important for maintaining peripheral tolerance, its ligand PD-L2 has recently been with morphogenetic protein activity. Here, we report that plays a central role in RA osteoimmunology.Femoral mineral density (BMD) trabecular microstructure were evaluated micro-CT wild type (WT) PD-L2-/- mice. Osteoclasts...
Abstract Background Practice patterns of follow-up after pulmonary embolism (PE) varies both within and between countries, high-quality evidence to provide clinical guidance is lacking [1,2]. This study part the trial – A sTrucTurEd INtegrateD post Pulmonary Embolism care model (Attend-PE) aimed at developing testing effectiveness a structured, integrated patient-centered for patients with PE. Purpose To explore experiences, perspectives, practice PE follow-up. Ultimately identifying...
<h3>Background:</h3> Co-inhibitory receptors are important for the regulation of inflammation in autoimmune diseases. Among these, T-cell Immunoglobulin and mucin domain-3 (Tim-3) has recently gained attention, as it is expressed on exhausted T cells co-expressing PD-1 (1). <h3>Objectives:</h3> To investigate Tim-3's role rheumatoid arthritis (RA). <h3>Methods:</h3> Early RA (eRA) patients were randomized to conventional methotrexate (MTX) treatment + placebo or MTX adalimumab (ADA) (2)....
ABSTRACT Cancers evade immune surveillance that in some, but not many, cases can be reversed through checkpoint therapy. Here we report the MYC oncogene suppresses surveillance, activates expression, and predicts responsiveness to inhibition. First, when is genomically amplified overexpressed 33 different human cancers, this increases drives therapeutic resistance, associated with both Th2-like profile, reduced CD8 T cell infiltration. Second, experimentally, MYC-driven tumors suppress...
Smoking and periodontitis are risk factors for developing rheumatoid arthritis (RA), suggesting a break of tolerance on mucosal surfaces. Immunoglobulin A (IgA) antibodies part the immune system. The dominant autoantibodies in RA anti-cyclic citrullinated protein (ACPAs), IgG IgA subclasses exist simultaneously. This study aimed to investigate association ACPA subtypes with disease activity long-term radiographic outcomes RA, compared IgG.Total IgG, IgA, IgA1, IgA2 were quantified serum from...
Summary A key phenomenon in cancer is the establishment of a highly immunosuppressive tumor microenvironment (TME). Despite advances immunotherapy, where purpose to induce recognition and hence hereof eradication, majority patients applicable for such treatment still fail respond. It has been suggested that high immunological activity essential achieving effective response which therefore have led exploration strategies triggers inflammatory pathways. Here activation stimulator interferon...
<div>Abstract<p>Cancers evade immune surveillance, which can be reversed through immune-checkpoint therapy in a small subset of cases. Here, we report that the MYC oncogene suppresses innate surveillance and drives resistance to immunotherapy. In 33 different human cancers, genomic amplification overexpression increased expression, predicted nonresponsiveness blockade, was associated with both Th2-like profile reduced CD8 T-cell infiltration. transcriptionally suppressed immunity...