A5063640282- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- interferon and immune responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Toxoplasma gondii Research Studies
- Immunodeficiency and Autoimmune Disorders
- Mosquito-borne diseases and control
- Microbial Inactivation Methods
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Parvovirus B19 Infection Studies
- Immune Response and Inflammation
- Chemokine receptors and signaling
- Cervical Cancer and HPV Research
- NF-κB Signaling Pathways
- HIV-related health complications and treatments
- Transgenic Plants and Applications
- Genital Health and Disease
Aalborg University
2008-2024
Faculty (United Kingdom)
2019
Laboratory of Molecular Genetics
2018
Aarhus University Hospital
2013-2016
Institute of Molecular Medicine
2015
Aarhus University
2006-2014
Herpes simplex encephalitis (HSE) in children has previously been linked to defects type I interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel genetic etiology HSE by identifying heterozygous loss-of-function mutation the IFN regulatory factor 3 (IRF3) gene, leading autosomal dominant (AD) IRF3 deficiency haploinsufficiency, an adolescent female patient with HSE. is activated most pattern recognition receptors recognizing viral infections and plays...
Abstract The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly induction of interferon inflammatory cytokines. Here we report that cGAMP stimulation leads transient decline ER cholesterol levels, mediated Sterol O-Acyltransferase 1-dependent esterification. This facilitates membrane curvature...
Osteopontin (OPN) is a cytokine with multiple functions, including immune defense mechanisms against invading microorganisms. OPN-deficient mice are impaired in clearing intracellular pathogens, suggesting an important role of OPN during phagocytosis, but it remains to be defined how may enhance this innate process. Here, we demonstrate that binds monocytes, not resting T cells, NK or B and mediates chemoattraction IL-1-activated human monocytes. Moreover, specific manner all known serotypes...
HIV infects key cell types of the immune system, most notably macrophages and CD4+ T cells. Whereas represent an important viral reservoir, activated cells are permissive supporting high levels replication. In recent years, it has been appreciated that innate system plays role in controlling replication, e.g. via interferon (IFN)-inducible restriction factors. Moreover, responses involved driving chronic activation pathogenesis progressive immunodeficiency. Several pattern recognition...
The innate immune system has been recognized to play a role in the pathogenesis of HIV infection, both by stimulating protective activities and through contribution chronic activation, development immunodeficiency progression AIDS. A for DNA sensors recognition suggested recently, aim present study was describe influence infection on expression function intracellular sensing. Here we demonstrate impaired interferon-stimulated genes responses peripheral blood monuclear cells from HIV-positive...
During recent years, inborn errors of human IL-17 immunity have been demonstrated to underlie primary immunodeficiencies with chronic mucocutaneous candidiasis (CMC). Various defects in receptors responsible for sensing Candida albicans or downstream signalling may lead susceptibility infection. While CMC is common patients profound T cell immunodeficiencies, also recognised as part other syndromic CMC, relatively isolated disease. We describe a 40-year-old woman clinical picture involving...
An analysis of all known human herpesviruses has not previously been reported on sperm from normal donors. Using an array-based detection method, we determined the cross-sectional frequency in semen 198 Danish Fifty-five donors had at least one ejaculate that was positive for or more herpesvirus. Of these 27.3% (n = 15) a double herpesvirus infection. If corrected presence multiple ejaculates some donors, adjusted 27.2% with HSV-1 0.4%; HSV-2 0.1%; EBV 6.3%; HCMV 2.7%; HHV-6A/B 13.5%; HHV-7...
ABSTRACT The immune system targets virus-infected cells by different means. One of the essential antiviral mechanisms is apoptosis induced ligation tumor necrosis factor receptor 1 (TNFR1). This can be activated alpha (TNF-α), which upon binding to TNFR1 induces assembly first an inflammatory and later a proapoptotic signaling complex. Here, we report that infection human herpesvirus 6B (HHV-6B) inhibited poly(ADP-ribose) polymerase (PARP) cleavage, caspase 3 8 activation, IκBα Ser-32...
Immunotherapeutic activation of tumor-specific T cells has proven to be an interesting approach in anticancer treatment. Particularly, anti-CTLA-4 and anti–PD-1/PD-L1 treatment looks promising, conceivably, even better clinical results might obtained if such could combined with boosting the existing T-cell response. One way achieve this by increasing level maturation dendritic locally draining lymph nodes. When exposed cancer cells, may spontaneously mature because danger-associated...
An issue with many current vaccines is the dependency on broadly inflammatory adjuvants, such as aluminum hydroxide or salts that affect immune- and non-immune cells. These adjuvants are not necessarily activating all antigen-presenting cells (APCs) take up antigen most likely they also activate APCs no uptake, well Conjugation of adjuvant would enable use smaller amounts avoid unnecessary tissue damage activation bystander It ensure become activated immature non-activated present to T...
Human herpesvirus 6B (HHV-6B) induces significant accumulation of p53 in both the nucleus and cytoplasm during infection. Activation by DNA damage is known to induce either growth arrest or apoptosis; nevertheless, HHV-6B-infected cells are arrested their cell cycle independently p53, only a minor fraction infected undergoes apoptosis. Using pifithrin-alpha, inhibitor, p53-null cells, this study showed that epithelial accumulated viral transcripts proteins significantly higher degree absence...
The SalI-L fragment from human herpesvirus 6A (HHV-6A) encodes a protein DR7 that has been reported to produce fibrosarcomas when injected into nude mice, transform NIH3T3 cells, and interact with inhibit the function of p53. homologous gene in HHV-6B is dr6. Since p53 deregulated both HHV-6A -6B, we characterized expression dr6 mRNA localization translated during infection HCT116 cells. Expression was inhibited by cycloheximide partly phosphonoacetic acid, known characteristic early/late...
Human herpesvirus 6B (HHV-6B) is the causative agent of common childhood febrile illness, exanthema subitum. The virus predominantly regarded as a T-cell tropic virus, although in reality it has ability to infect wide variety cell types including monocytes, macrophages and dendritic cells (DC). Although DC are important immune regulators, modulating effects HHV-6B on controversial. Here, we examine phenotypic functional consequences infection DC. addition immature led expression nuclear...
Infection with human herpesvirus (HHV)-6B alters cell cycle progression and stabilizes tumor suppressor protein p53. In this study, we have analyzed the activity of p53 after stimulation p53-dependent -independent DNA damaging agents during HHV-6B infection. Microarray analysis, Western blotting confocal microscopy demonstrated that HHV-6B-infected cells were resistant to arrest death γ irradiation in both permissive non-permissive lines. contrast, died normally through p53-independet damage...
Human herpesvirus 6B (HHV-6B) contains an IE-B domain spanning open reading frames U16/17-U19, based on homology with human cytomegalovirus. Here, the protein product, U19, of HHV-6B U19 gene is identified as a 47 kDa transcriptional activator. infection or overexpression transactivated RANTES promoter. Mutational analysis promoter indicated that transactivation was not critically dependent sites CRE, NF-kappaB, ISRE NF-IL6. ND10 are nuclear substructures involved in several cellular...