A5047191391- interferon and immune responses
- Viral Infections and Vectors
- Aquaculture disease management and microbiota
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Virus-based gene therapy research
- Inflammasome and immune disorders
- Animal Virus Infections Studies
- RNA regulation and disease
- Herpesvirus Infections and Treatments
- Mosquito-borne diseases and control
- Cytokine Signaling Pathways and Interactions
- Animal Disease Management and Epidemiology
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Streptococcal Infections and Treatments
- Particle accelerators and beam dynamics
- Oral microbiology and periodontitis research
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Autoimmune and Inflammatory Disorders Research
- Fusion materials and technologies
- Viral Infections and Outbreaks Research
- Microbial infections and disease research
Aarhus University
2018-2024
Chinese Academy of Sciences
2010-2021
University of Chinese Academy of Sciences
2014-2021
Institute of Modern Physics
2021
Institute of Oceanology
2014-2017
Qingdao National Laboratory for Marine Science and Technology
2017
Institute of Zoology
2014
Plant Biosecurity Cooperative Research Centre
2014
Institute of Plant Protection
2014
Chinese Academy of Agricultural Sciences
2014
Polyinosinic:polycytidylic acid (poly(I:C)) is a ligand of toll-like receptor (TLR) 3 that has been used as an immunostimulant in humans and mice against viral diseases based on its ability to enhance innate adapt immunity. Antiviral effect poly(I:C) also observed teleost, however, the underling mechanism not clear. In this study, we investigated potential signaling antiviral agent model Japanese flounder (Paralichthys olivaceus) infected with megalocytivirus. We found exhibited strong...
Herpes simplex virus (HSV) is the main cause of viral encephalitis in Western world, and type I interferon (IFN) system important for antiviral control brain. Here, we have compared Ifnb induction mixed murine brain cell cultures by a panel HSV1 mutants, each devoid one mechanism to counteract IFN-stimulating cGAS-STING pathway. We found that mutant lacking deubiquitinase (DUB) activity VP1-2 protein induced particularly strong expression IFN-stimulated genes. ΔDUB also elevated IFN human...
Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral defense, but may also promote pathological inflammation. A range diseases characterized by elevated IFN-I, including systemic lupus erythematosus (lupus). The DNA-activated cGAS-STING pathway is a major IFN-I-inducing pathway, activation signaling dependent on trafficking STING from the ER to Golgi.Here we used cell culture systems, mouse model, material patients, explore mode action antagonistic peptide, its...
Abstract The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly induction of interferon inflammatory cytokines. Here we report that cGAMP stimulation leads transient decline ER cholesterol levels, mediated Sterol O-Acyltransferase 1-dependent esterification. This facilitates membrane curvature...
MicroRNAs (miRNAs) regulate gene expression by binding to mRNA transcripts in various biological processes. In mammals and birds, miRNAs are known play vital parts both host immune defense viral infection. However, lower vertebrates such as teleost, systematic investigations on lacking. this study, we applied high-throughput sequencing technology identify analyze Japanese flounder (Paralichthys olivaceus), an economically important teleost fish farmed widely the world, infected with...
Megalocytivirus is a DNA virus that highly infectious in wide variety of marine and freshwater fish, including Japanese flounder (Paralichthys olivaceus), flatfish farmed worldwide. However, the infection mechanism megalocytivirus remains largely unknown. In this study, we investigated function microRNA, pol-miR-731, virus-host interaction. We found pol-miR-731 was induced expression by promoted viral replication at early stage. vivo vitro studies revealed (i) specifically suppresses...
There is growing evidence that porcine reproductive and respiratory syndrome virus (PRRSV) has developed mechanisms to subvert the host innate immune response. PRRSV non-structural protein 2 (Nsp2) was suggested previously as a potential interferon (IFN) antagonist. This study focused on Nsp2 investigate its inhibitory mechanism of IFN induction. It demonstrated strongly inhibited IFN-β production by antagonizing activation regulatory factor 3 (IRF-3) pathway induced Sendai (SeV). Further...
Streptococcus iniae is a Gram-positive bacterium that reckoned one of the most severe aquaculture pathogens. It has broad host range among farmed marine and freshwater fish can also cause zoonotic infection in humans. Here we report for first time complete genome sequence as well factor-induced proteomic profile pathogenic S. strain, SF1, serotype I isolate from diseased fish. SF1 possesses single chromosome 2,149,844 base pairs, which contains 2,125 predicted protein coding sequences (CDS),...
Abstract Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus exclusively infecting humans, causing two distinct pathologies: varicella (chickenpox) upon primary infection and herpes (shingles) following reactivation. In susceptible individuals, VZV can give rise to more severe clinical manifestations, including disseminated infection, pneumonitis, encephalitis, vasculopathy with stroke. Here, we describe 3-year-old boy in whom followed complicated course thrombocytopenia,...
Pattern recognition receptors (PRRs) induce host defense but can also exacerbated inflammatory responses. This raises the question of whether other mechanisms are involved in early defense. Using transcriptome analysis disrupted transcripts herpes simplex virus (HSV)-infected cells, we find that HSV infection disrupts hypoxia-inducible factor (HIF) transcription network neurons and epithelial cells. Importantly, HIF activation leads to control replication. Mechanistically, induces autophagy,...
This study investigated the population genetics, demographic history and pathway of invasion Russian wheat aphid (RWA) from its native range in Central Asia, Middle East Europe to South Africa Americas. We screened microsatellite markers, mitochondrial DNA endosymbiont genes 504 RWA clones nineteen populations worldwide. Following analyses data, we postulate that Turkey Syria were most likely sources Kenya Africa, respectively. Furthermore, found one clone transferred between Americas was...
Critical COVID-19 is characterized by lack of early type I interferon-mediated host defense and subsequent hyper-inflammation in the lungs. Aberrant activation macrophages neutrophils has been reported to lead excessive innate immunological pathways. It recently suggested that DNA-sensing cGAS–STING pathway drives pathology SARS-CoV-2–infected lungs, but mechanistic understanding from vivo models needed. Here, we tested whether STING involved COVID-19-like disease using K18-hACE2 mouse...
Streptococcus iniae is a Gram-positive bacterium and severe pathogen to wide range of economically important fish species. In addition, S. also zoonotic can cause serious infections in humans. this study, we identified from pathogenic strain putative bacteriocin, Sil, examined its biological activity. Sil composed 101 amino acid residues shares 35.6% overall sequence identity with the lactococcin 972 Lactococcus lactis. Immunoblot analysis showed that was secreted by into extracellular...
Incoming viruses challenge the cell with diverse foreign molecules, which need to be sensed quickly initiate immune responses and remove viral components. In this study, we investigate cellular requirements for sensing degradation of incoming DNA capsids during herpes simplex virus type 1 (HSV-1) infections. Using click chemistry labeling genome, found that HSV-1 was released from a subset into cytosol early in infection. By next-generation sequencing cyclic GMP-AMP (cGAMP) synthase...
Abstract DNA is a danger signal sensed by cGAS to engage signaling through STING activate innate immune functions. The best-studied downstream responses activation include expression of type I interferon and inflammatory genes, but also activates other pathways, including apoptosis. Here, we report that STING-dependent induction apoptosis in macrophages occurs the intrinsic mitochondrial pathway mediated via IRF3 acts independently gene transcription. By intersecting four mass spectrometry...