A5067859146- Multiple Myeloma Research and Treatments
- interferon and immune responses
- Peptidase Inhibition and Analysis
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- PI3K/AKT/mTOR signaling in cancer
- Parasites and Host Interactions
- Herpesvirus Infections and Treatments
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Viral Infections and Vectors
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
Aarhus University Hospital
2023-2025
Aarhus University
2023-2025
Max Delbrück Center
2021-2023
Hiroshima University
2023
Charité - Universitätsmedizin Berlin
2021-2023
Abstract Heligmosomoides polygyrus co-infection is reported to have protective antiviral effects against pulmonary viral infections. To investigate a potential underlying mechanism, we infected C57BL/6 mice with H. larvae for two weeks. Bone marrow (BM)-derived plasmacytoid dendritic cells (pDCs) were generated and stimulated TLR agonists. We found increased expression of type 1 interferon genes (Ifnα1, Ifnα4, Ifnβ1, Mx1, Isg15), TNF, IL-6, IL-10 secretion, higher antigen presentation...
Highlights•Circulating stem cell-generated pDCs cross-present antigen to autologous CD8+ T cells•Antigen-presenting activate cells proliferate and secrete cytokines•Antigen-presenting induce a transcriptomic signature distinct from mDCsSummaryPlasmacytoid dendritic (pDCs) play pivotal role in immune responses, particularly against viral infections. exhibit diverse functions, including interferon production, cytokine secretion, presentation. Here, we investigate the cross-presentation...
Abstract Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus exclusively infecting humans, causing two distinct pathologies: varicella (chickenpox) upon primary infection and herpes (shingles) following reactivation. In susceptible individuals, VZV can give rise to more severe clinical manifestations, including disseminated infection, pneumonitis, encephalitis, vasculopathy with stroke. Here, we describe 3-year-old boy in whom followed complicated course thrombocytopenia,...
Multiple myeloma (MM), a tumor of germinal center (GC)-experienced plasma cells, comprises distinct genetic subgroups, such as the t(11;14)/CCND1 and t(4;14)/MMSET subtype. We have generated genetically defined, subgroup-specific MM models by GC B cell-specific coactivation mouse Ccnd1 or MMSET with constitutively active Ikk2 mutant, mimicking secondary NF-κB activation frequently seen in human MM. Ccnd1/Ikk2ca MMSET/Ikk2ca mice developed pronounced, clonally restricted cell outgrowth age,...
Abstract Multiple myeloma (MM), a tumor of germinal center (GC)-experienced plasma cells, comprises distinct genetic subgroups, such as the t(11;14)/CCND1 and t(4;14)/MMSET subtype. We have generated subgroup-specific MM models by GC B cell-specific co-activation Ccnd1 or MMSET with constitutively active Ikk2 mutant, mimicking secondary NFκB activation frequently seen in human MM. Ccnd1/Ikk2ca MMSET/Ikk2ca mice developed pronounced, clonally restricted cell outgrowth age, accompanied serum M...