A5019400294- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- interferon and immune responses
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Image Processing Techniques and Applications
- Ubiquitin and proteasome pathways
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
Aalborg University
2017-2024
Oslo University Hospital
2024
University of Oslo
2024
Faculty (United Kingdom)
2018-2019
New York University Press
2017
Cambridge University Press
2017
Abstract The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly induction of interferon inflammatory cytokines. Here we report that cGAMP stimulation leads transient decline ER cholesterol levels, mediated Sterol O-Acyltransferase 1-dependent esterification. This facilitates membrane curvature...
Immunotherapeutic activation of tumor-specific T cells has proven to be an interesting approach in anticancer treatment. Particularly, anti-CTLA-4 and anti–PD-1/PD-L1 treatment looks promising, conceivably, even better clinical results might obtained if such could combined with boosting the existing T-cell response. One way achieve this by increasing level maturation dendritic locally draining lymph nodes. When exposed cancer cells, may spontaneously mature because danger-associated...
Abstract Conserved epitopes shared between virus subtypes are often subdominant, making it difficult to induce broadly reactive antibodies by immunization. Here, we generate a plasmid DNA mix vaccine that encodes protein heterodimers with sixteen different influenza A hemagglutinins (HA) representing all HA except H1 (group 1) and H7 2). Each single heterodimer expresses two is targeted MHC class II on antigen presenting cells (APC). Female mice immunized the produce not only against 16...
An issue with many current vaccines is the dependency on broadly inflammatory adjuvants, such as aluminum hydroxide or salts that affect immune- and non-immune cells. These adjuvants are not necessarily activating all antigen-presenting cells (APCs) take up antigen most likely they also activate APCs no uptake, well Conjugation of adjuvant would enable use smaller amounts avoid unnecessary tissue damage activation bystander It ensure become activated immature non-activated present to T...