A5018047889- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Alcohol Consumption and Health Effects
- Diabetes and associated disorders
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Adipose Tissue and Metabolism
- Cellular Mechanics and Interactions
- Protease and Inhibitor Mechanisms
- Aortic Disease and Treatment Approaches
- Endoplasmic Reticulum Stress and Disease
- Connective Tissue Growth Factor Research
- Hippo pathway signaling and YAP/TAZ
- Diet and metabolism studies
- Cardiac, Anesthesia and Surgical Outcomes
Stanford University
2020-2024
Stanford Medicine
2022
Mayo Clinic in Arizona
2019-2020
Abstract Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development 1,2 , and increased stiffness known promote HCC progression cirrhotic conditions 3,4 . characterized by an accumulation of advanced glycation end-products (AGEs) the ECM; however, how this affects non-cirrhotic unclear. Here we find that, patients animal models, AGEs changes collagen architecture enhance ECM...
Type 2 diabetes is clinically associated with progressive necroinflammation and fibrosis in nonalcoholic steatohepatitis (NASH). Advanced glycation end-products (AGEs) accumulate during prolonged hyperglycemia, but the mechanistic pathways that lead to accelerated liver have not been well defined. In this study, we show AGEs clearance receptor AGER1 was downregulated patients NASH our models, whereas proinflammatory RAGE induced. These findings were necroinflammatory, fibrogenic, pro-oxidant...
Background and Aims Older patients with obesity/type II diabetes mellitus frequently present advanced NASH. Whether this is due to specific molecular pathways that accelerate fibrosis during aging unknown. Activation of the Src homology 2 domain–containing collagen‐related (Shc) proteins redox stress have been recognized in aging; however, their link NASH has not explored. Approach Results Shc expression increased livers older NASH, as assessed by real time quantitative PCR (RT‐qPCR) or...
Abstract Type 2 diabetes mellitus (T2DM) is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development, and increased stiffness known promote HCC progression cirrhotic conditions. T2DM characterized by an accumulation of advanced glycation end products (AGEs) the ECM; however, how this affects non-cirrhotic conditions unclear. Here, we find that patients animal models AGEs changes collagen architecture enhance ECM...