A5000958725- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
- Metabolism, Diabetes, and Cancer
- Bone Tumor Diagnosis and Treatments
- Bone health and treatments
- Clinical Nutrition and Gastroenterology
- Ovarian function and disorders
- Bone and Joint Diseases
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Prenatal Substance Exposure Effects
- Reproductive System and Pregnancy
- Growth Hormone and Insulin-like Growth Factors
- Pharmacology and Obesity Treatment
- Sperm and Testicular Function
- Nutrition and Health in Aging
- Exercise and Physiological Responses
- Medication Adherence and Compliance
- Medical Imaging and Pathology Studies
- Pharmaceutical studies and practices
Brigham and Women's Hospital
2023
Harvard University
2018-2023
Massachusetts General Hospital
2021-2023
Broad Institute
2023
Brown University
2017-2023
Rhode Island Hospital
2023
Providence College
2018-2023
Harvard Pilgrim Health Care
2023
University of South Florida
2023
GTx (United States)
2022
Context Polycystic ovary syndrome (PCOS) is a chronic condition with metabolic manifestations spanning the reproductive years. Objective We sought to examine glucose metabolism, irrespective of presence obesity in cohort adolescent girls PCOS. Design One hundred adolescents were assessed for PCOS multi-specialty program. was diagnosed by Androgen Excess Society criteria. Oral tolerance testing (OGTT), homeostatic model assessment insulin resistance, and androgen lipid profiles performed...
OBJECTIVE Pregnant individuals are universally screened for gestational diabetes mellitus (GDM). Gestational glucose intolerance (GGI) (an abnormal initial GDM screening test without a diagnosis) is not recognized risk factor. We tested an association between GGI and after pregnancy. RESEARCH DESIGN AND METHODS conducted retrospective cohort study of followed prenatal primary care. defined as glucose-loading result at ≥24 weeks’ gestation with oral tolerance (OGTT) that did meet criteria....
Type 2 diabetes and obesity are risk factors for endometrial hyperplasia cancer, suggesting that hyperinsulinemia contributes to pathogenesis. Insulin action through insulin receptor (IR) splice variants IR-A IR-B regulates cellular mitogenesis metabolism, respectively.
To evaluate the risks of large-for-gestational-age birth weight (LGA) and weight-related complications in pregnant individuals with gestational glucose intolerance, an abnormal screening loading test result without meeting diabetes mellitus (GDM) criteria.
Identification of cancer or inflammatory bowel disease in the intestinal tract by PET/computed tomography (CT) imaging can be hampered physiological uptake F-fluorodeoxyglucose (F-FDG) normal colon. Previous work has localized this F-FDG to lumen, predominantly occupied bacteria. We sought determine whether pretreatment with an antibiotic could reduce healthy colon.Thirty patients undergoing restaging PET/CT for nongastrointestinal lymphoma were randomly selected receive rifaximin 550 mg...
Patients with fibrous dysplasia (FD) often present craniofacial lesions that affect the trigeminal nerve system. Debilitating pain, headache, and migraine are frequently experienced by FD patients poor prognosis, while some individuals similar bone asymptomatic. The clinical biological factors contribute to etiopathogenesis of pain in largely unknown. We two adult females comparable lesion size location, as measured 18 F-sodium fluoride positron emission tomography/computed tomography...
Abstract Disclosure: D. Mendez: None. M.G. Fernandez: D.J. Selen: Background: Endogenous Cushing syndrome may result from an ectopic non-pituitary tumor. Severe hypercortisolism has high mortality, so prompt medical management to acutely decrease cortisol levels is necessary when no surgical options are available. Clinical Case: A 67-year-old male presented the hospital with four weeks of fatigue and was found have a right hilar mass unsuppressed for which tumor suspected. On initial...
Abstract Background: Women with gestational diabetes mellitus (GDM) and glucose intolerance (GGI, abnormal initial GDM screening test) their infants have an increased risk of adverse perinatal outcomes including large for age birth weight (LGA), pregnancy-related hypertension, neonatal intensive care unit (NICU) admission, cesarean delivery. We expanded a prior analysis defining physiologic subtypes GGI categorized by insulin resistance, deficiency, or mixed pathophysiology. aimed to...
A 29-year-old woman presented with recurrent bone fractures and hypophosphatemia. The patient had been well until 19 months before admission, when pain in the right foot developed. During next months, multiple of metatarsal bones occurred. On blood phosphorus level was 1.0 mg per deciliter. diagnostic test performed.
Abstract Disclosure: M.G. Fernandez: None. D.J. Selen: Background: Nonislet cell tumor hypoglycemia is an uncommon but severe complication of cancer. It results from tumoral overproduction insulin-like growth factor 2 (IGF-2), which inhibits hepatic glycogenolysis and the release glucagon hormone (GH). These three mechanisms can result in refractory hypoglycemia. Clinical Case: We present a case 57-year-old female newly diagnosed with metastatic cholangiocarcinoma who was admitted to...
Introduction: The prevalence of non-alcoholic fatty liver disease (NAFLD) continues to rise among pregnant individuals. While NAFLD has a strong link hypertension outside pregnancy, data on the risk hypertensive disorders pregnancy (HDP) in are limited. Among individuals with overweight or obese body mass index (BMI), we aimed compare HDP those and without NAFLD. Methods: We performed retrospective cohort study pregnancies cared for at US academic center from 1998 2016. Singleton were...
Hyperglycemia is a common complication in hospitalized patients with type 2 diabetes mellitus (T2DM) on continuous enteral nutrition therapy (ENT). The purpose of this study was to identify an insulin regimen for patient population that provided adequate coverage hyperglycemia without significant hypoglycemia. A retrospective chart review conducted at the University Vermont Medical Center noncritically ill admitted between 07/01/2012 and 09/01/2015 who had T2DM received ENT ≥72 hours—209 met...
<p> </p> <p><strong>Objective:</strong> Pregnant individuals are universally screened for gestational diabetes. Gestational glucose intolerance (GGI, an abnormal initial diabetes screening test without a diagnosis) is not recognized risk factor. We tested association between GGI and after pregnancy.</p> <p><strong>Research Design Methods:</strong> conducted retrospective cohort study of followed prenatal primary care. defined as loading...
<p> </p> <p><strong>Objective:</strong> Pregnant individuals are universally screened for gestational diabetes. Gestational glucose intolerance (GGI, an abnormal initial diabetes screening test without a diagnosis) is not recognized risk factor. We tested association between GGI and after pregnancy.</p> <p><strong>Research Design Methods:</strong> conducted retrospective cohort study of followed prenatal primary care. defined as loading...