A5056799177- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diabetes Management and Research
- Metabolomics and Mass Spectrometry Studies
- FOXO transcription factor regulation
- Regulation of Appetite and Obesity
- Innovations in Medical Education
- Skin and Cellular Biology Research
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Health Systems, Economic Evaluations, Quality of Life
- Ultrasound in Clinical Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism and Genetic Disorders
- Gestational Diabetes Research and Management
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Healthcare Policy and Management
- Gene expression and cancer classification
- Lipid metabolism and disorders
University of California, San Diego
2009-2024
Rady Children's Hospital-San Diego
2009-2024
UC San Diego Health System
2024
University of Hong Kong
2024
Harvard University
2016-2017
University of California, San Francisco
2004-2011
San Francisco General Hospital
2010
Yale University
2004
Columbia University
2001-2002
Henry Ford Health System
1999-2001
Health policy instruments such as the public financing of health technologies (e.g., new drugs, vaccines) entail consequences in multiple domains. Fundamentally, policies aim at increasing uptake effective and efficient interventions subsequently leading to better benefits premature mortality morbidity averted). In addition, can provide non-health addition sole well-being populations beyond sector. For instance, social insurance programs prevent illness-related impoverishment procure...
SARS-CoV-2 Infections and Presymptomatic Type 1 Diabetes Autoimmunity in Children Adolescents From Colorado, USA, Bavaria, Germany
Chronic inflammation is a key feature of insulin resistance and obesity. Toll-Like Receptor 4 (TLR4), involved in modulating innate immunity, an important mediator its comorbidities. TLR4 contributes to the development through activation by elevated exogenous ligands (e.g., dietary fatty acids enteric lipopolysaccharide) endogenous free acids) which are obese states. TLR4, expressed target tissues, activates proinflammatory kinases JNK, IKK, p38 that impair signal transduction directly...
Background and Purpose— Collateral flow plays an important role in maintaining tissue viability proximal large vessel occlusion. We developed tested a regional angiographic collateral grading system for patients with angiographically confirmed acute symptomatic middle cerebral artery occlusion to predict infarction. Methods— A subset of 42 was selected from 180 enrolled the Prolyse Acute Cerebral Thromboembolism II (PROACT II) trial. Readers evaluated baseline angiograms blinded fashion...
The transcriptional factor FoxO1 plays an important role in metabolic homeostasis. Herein we identify a novel transrepressional function that converts from activator of transcription to promoter-specific repressor peroxisome proliferator-activated receptor γ (PPARγ) target genes regulate adipocyte biology. transrepresses PPARγ via direct protein-protein interactions; it is recruited PPAR response elements (PPRE) on by bound PPRE and interferes with promoter DNA occupancy the receptor....
OBJECTIVE Forkhead box O (FoxO) transcription factors represent evolutionarily conserved targets of insulin signaling, regulating metabolism and cellular differentiation in response to changes nutrient availability. Although the FoxO1 isoform is known play a key role adipogenesis, its physiological differentiated adipose tissue remains unclear. RESEARCH DESIGN AND METHODS In this study, we analyzed phenotype haploinsufficient mice investigate high-fat diet–induced obesity metabolism. RESULTS...
GPR105, a G protein-coupled receptor for UDP-glucose, is highly expressed in several human tissues and participates the innate immune response. Because inflammation has been implicated as key initial trigger type 2 diabetes, we hypothesized that GPR105 (official gene name: P2RY14) might play role initiation of insulin resistance obesity. To this end, investigated glucose metabolism knockout (KO) wild-type (WT) mice fed high-fat diet (HFD). We also examined whether regulates macrophage...
Aging is associated with a decline in multiple aspects of cognitive function, spatial cognition being particularly sensitive to age-related decline. Environmental stressors, such as high-fat diet (HFD) exposure, that produce diabetic phenotype and metabolic dysfunction may indirectly lead exacerbated brain aging promote the development deficits. The present work investigated whether exposure HFD exacerbates deficits adult versus aged mice. Adult (5 months old) (15 mice were exposed control...
Obesity-induced inflammation is a key component of systemic insulin resistance, which hallmark type 2 diabetes. A major driver this inflammation/insulin resistance syndrome the accumulation proinflammatory macrophages in adipose tissue and liver. We found that orphan GPCR Gpr21 was highly expressed hypothalamus mice whole-body KO receptor led to robust improvement glucose tolerance sensitivity modest lean phenotype. The high-fat diet-fed (HFD-fed) mouse traced marked reduction caused by...
The incidence of type 2 diabetes is increasing more rapidly in adolescents than any other age group. We identified and compared metabolite signatures obese children with (T2D), without (OB), healthy, age- gender-matched normal weight controls (NW) by measuring 273 analytes fasting plasma 24-hour urine samples from 90 subjects targeted LC-MS/MS. Diabetic were within years diagnosis an attempt to capture early-stage disease prior declining renal function. found 22 metabolites that uniquely...
Type 2 diabetes is highly prevalent in human populations, particularly obese individuals, and characterized by progressive pancreatic β-cell dysfunction insulin resistance. Most mammals, including Old World primates, express two major kinds of sialic acids, Af-acetylneuraminic acid (Neu5Ac) Af-glycolylneuraminic (Neu5Gc), typically found at the distal ends glycoconjugate chains cell surface. Humans are uniquely unable to produce endogenous Neu5Gc due an inactivating mutation CMP-Neu5Ac...
Adult Refsum disease (ARD) is a rare peroxisomal biogenesis disorder inherited in an autosomal recessive fashion and often characterized by retinitis pigmentosa, cerebellar ataxia, polyneuropathy. Many patients with ARD require diet modification, psychosocial support, various specialist visits to manage their symptoms. In this study, we explored the quality of life individuals analyzing retrospective survey data collected Coordination Rare Diseases at Sanford (CoRDS) Registry Global Defeat...
Anal cancer is one of the most common cancers affecting human immunodeficiency virus (HIV)-infected male patients. Currently, there no consensus on posttreatment surveillance HIV-infected men who have sex with (MSM) been treated for high-grade intraepithelial neoplasia (HGAIN), likely precursor to anal cancer.
Background: High-Fat Diet (HFD)-induced obesity may promote agerelated memory impairment via disturbances of ammonia-glutamine metabolism. Objective: We studied the effects age and long-term HFD exposure on Glutamine Synthetase (GS) expression in liver hippocampus recognition mice. Methods: Adult (5-month-old) aged (15-month-old) male C57BL/6 mice were exposed to control diet (CD, 14% calories from fat) or (60% fat). Novel place testing was conducted tissue collected after 4 5 months HFD,...