A5075906136- Personality Disorders and Psychopathology
- Health Systems, Economic Evaluations, Quality of Life
- Mental Health and Psychiatry
- Global Cancer Incidence and Screening
- Psychotherapy Techniques and Applications
- Colorectal Cancer Screening and Detection
- Asthma and respiratory diseases
- HIV/AIDS Research and Interventions
- Child and Adolescent Psychosocial and Emotional Development
- Per- and polyfluoroalkyl substances research
- Health Policy Implementation Science
- Obsessive-Compulsive Spectrum Disorders
- Economic and Financial Impacts of Cancer
- Breast Cancer Treatment Studies
- Treatment of Major Depression
- Mental Health Treatment and Access
- Delphi Technique in Research
- Bipolar Disorder and Treatment
- Adolescent and Pediatric Healthcare
- HIV/AIDS Impact and Responses
- demographic modeling and climate adaptation
- Healthcare cost, quality, practices
- Health and Medical Research Impacts
- Autoimmune Neurological Disorders and Treatments
- BRCA gene mutations in cancer
Brigham and Women's Hospital
2021-2024
Harvard University
2010-2024
Massachusetts General Hospital
2020-2022
McLean Hospital
2020
Tufts Medical Center
2014-2015
Harvard University Press
2014
Tufts University
2014
De Viersprong
2005-2012
University of Amsterdam
2011-2012
Erasmus MC
2011
Article AbstractObjective: Some evidence suggests that personality disorders are associated with a high economic burden due to, for example, demand on psychiatric, health, and social care services. However, state-of-the-art cost studies the broad range of disorder diagnoses lacking. The present study examines direct medical costs, as well indirect patients seeking mental health treatment DSM-IV disorders. Method: 1740 subjects included in this were recruited from March 2003 to 2006 6...
A generic quality of life measure was used to investigate the burden disease in a large sample patients with personality disorders. The 1,708 subjects included this study were recruited from six different mental health care institutes Netherlands. measured using EuroQol EQ-5D. Personality disorders diagnosed Structured Interview for DSM-IV (SIDP-IV). mean EQ-5D index value 0.56. Primarily total number disorder diagnoses rather than specific type determined life. Notably borderline not...
Generic preference-based measures (EuroQoL-5D (EQ-5D) and SF-6D) are used in the economic evaluation of mental health interventions. However, there inconsistent findings regarding their psychometric properties.To investigate properties EQ-5D SF-6D different conditions, using seven existing data-sets.The construct validity responsiveness were assessed comparison with condition-specific indicators.Evidence for common personality disorders was found (correlations 0.22-0.64; effect sizes...
Background: Targeting low-dose computed tomography (LDCT) for lung cancer screening to persons at highest risk mortality has been suggested improve efficiency. Objective: To quantify the value of risk-targeted selection compared with National Lung Screening Trial (NLST) eligibility criteria. Design: Cost-effectiveness analysis using a multistate prediction model. Data Sources: NLST. Target Population: Current and former smokers eligible screening. Time Horizon: Lifetime. Perspective: Health...
Recommendations on current clinical guidelines are informed by limited economic evidence.A formal evaluation of three modalities psychotherapy for patients with cluster B personality disorders.A probabilistic decision-analytic model to assess the cost-effectiveness out-patient, day hospital and in-patient over 5 years in terms cost per recovered patient-year quality-adjusted life-year (QALY). Analyses were conducted from both societal payer perspectives.From perspective, most cost-effective...
Objective: This study aimed to estimate the cost-effectiveness of esketamine, a novel intranasally dosed antidepressant, for patients in United States with treatment-resistant depression. Methods: A decision-analytic model parameterized efficacy data from phase 3 randomized trials esketamine was used simulate effects treatment versus oral antidepressants over 5-year horizon, both societal and health care sector perspectives. Outcomes included remission response depression, quality-adjusted...
Abstract Background Bibliometric analyses show gender bias against women in scientific publications and citations. We hypothesized that a metric of an individual senior author’s inclusivity as first authors critical care would predict inequality. Methods Using PubMed Web Science, we conducted bibliometric analysis original research from 2008 to 2018 11 specialty general journals. Gender for was assigned by determination application, manually if needed. For all defined the novel Female First...
Colorectal cancer is one of the most common cancers worldwide and associated with high mortality when detected at a later stage. There paucity studies from low middle income countries to support cost-effectiveness colorectal screening. We aim analyze screening compared no in Ukraine, lower-middle country. developed deterministic Markov cohort model assess three strategies [fecal occult blood test (FOBT) every year, flexible sigmoidoscopy FOBT 5 years, colonoscopy 10 years] modeled outcomes...
Article Abstract Objective: To conduct a formal economic evaluation of various dosages psychotherapy for patients with avoidant, dependent, and obsessive-compulsive (ie, cluster C) personality disorders (Structured Interview DSM-IV Personality criteria). Method: We developed decision-analytic model to assess the cost-effectiveness 5 long-term outpatient psychotherapy, short-term day hospital inpatient psychotherapy) over 5-year time horizon in terms cost per recovered patient-year...
BackgroundThe prevalence of ductal carcinoma in situ (DCIS) and the marked variability patterns care highlight need for comparative effectiveness research. We sought to quantify tradeoffs among alternative management strategies DCIS with respect disease outcomes breast preservation.
Article Abstract Objective: Autoimmune encephalitis (AE) is a highly treatable neurologic condition that can cause psychosis. Screening for AE not currently recommended in routine workup first-episode psychosis (FEP), owing partly to the high cost of testing AE-associated neuronal autoantibodies. Methods: This study used decision-analytic model estimate cost-effectiveness serum screening compared with clinically targeted patients FEP. Model parameters drawn from prior published literature...
The burden of disease 1,651 inpatients in the Netherlands who had complex personality problems and disorders were treated specialized units that provide psychotherapy was compared with patients other mental physical conditions. Patients completed EuroQol EQ-5D, a generic quality-of-life questionnaire. mean EQ-5D index score .54 (possible scores range from -.59 to 1.00, higher indicating fewer problems). This reflects comparable severe illnesses, such as Parkinson's (.58) or rheumatic (.53).
Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic, highly fluorinated aliphatic compounds, commonly utilised in wide variety consumer products with diverse applications.
Background: Healthcare payers in the United States are increasingly tying provider payments to quality and value using pay-for-performance policies. Cost-effectiveness analysis quantifies healthcare but is not currently used design or prioritize strategies metrics. Acute ischemic stroke care provides a useful application demonstrate how simulation modeling can be determine cost-effective levels of financial incentives policies associated challenges with this approach. Methods Results: Our...
Metamodels can simplify complex health policy models and yield instantaneous results to inform decisions. We investigated the predictive validity of linear regression metamodels used support a real-time decision-making tool that compares infant HIV testing/screening strategies.
Abstract Introduction To improve the diagnosis and survival of children living with HIV (CLWH), World Health Organization recommends testing approaches beyond traditional infant programmes. Information about undiagnosed prevalence among varying ages in general population is needed to guide innovative national/subnational case‐finding approaches. Methods We used Cost‐Effectiveness Preventing AIDS Complications (CEPAC)‐Pediatric model estimate 2‐, 5‐ 10‐year‐old South Africa, Côte d'Ivoire...