A5074205499- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Breastfeeding Practices and Influences
- Child and Adolescent Health
- Pregnancy and Medication Impact
- Vitamin D Research Studies
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Reproductive System and Pregnancy
- Adrenal Hormones and Disorders
- Birth, Development, and Health
- Cystic Fibrosis Research Advances
- Studies on Chitinases and Chitosanases
- Stress Responses and Cortisol
- Preterm Birth and Chorioamnionitis
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Food Allergy and Anaphylaxis Research
- Obstructive Sleep Apnea Research
- Allergic Rhinitis and Sensitization
- Delphi Technique in Research
- Airway Management and Intubation Techniques
- Epigenetics and DNA Methylation
Stanford University
2022-2024
Harvard University
2020-2024
Brigham and Women's Hospital
2020-2024
Helsinki University Hospital
2016-2020
University of Helsinki
2015-2020
Allergy and Asthma Federation
2014
Rationale: A link among sphingolipids, 17q21 genetic variants, and childhood asthma has been suggested, but the underlying mechanisms characteristics of such an endotype remain to be elucidated.Objectives: To study sphingolipid-associated using multiomic data.Methods: We used untargeted liquid chromatography-mass spectrometry plasma metabolomic profiles at ages 6 months years from more than 500 children in COPSAC2010 (Copenhagen Prospective Studies on Asthma Childhood) birth cohort focusing...
Reduced lung function in early childhood is associated with persistent symptoms and low later life. Impulse oscillometry (IOS) feasible for assessing also preschool children, some of the parameters, such as respiratory resistance at 5 Hz (Rrs5) frequency dependence (dRrs/df), have been suggested to reflect small airway dysfunction. Whether changes IOS predict remains unknown.The medical data 154 asthmatic children performed 2-7 years spirometry 12-18 were analyzed. post-bronchodilator...
Prenatal vitamin D3 supplementation has been linked to reduced risk of early-life asthma/recurrent wheeze. This protective effect appears be influenced by variations in the 17q21 functional single nucleotide polymorphism rs12936231 child, which regulates expression ORMDL3 (ORM1-like 3) and for high-risk CC genotype is associated with early-onset asthma. However, this does not fully explain differential effects supplementation. We investigated influence maternal variation on prenatal against...
Summary Introduction: Early origins of chronic obstructive pulmonary disease have been recognized. Impulse oscillometry (IOS) is suitable for assessment lung function also in preschool children, and some novel indices connected to small airway function. However, limited data exist on the sensitivity these new detect deficits young symptomatic children. Methods: IOS measurements 103 healthy children were evaluated establish reference equations difference between respiratory resistance at 5 20...
Objective The determinants of preterm birth remain unknown. Excessive maternal inflammation during pregnancy may play an important role in the pathogenesis birth. Our objective was to describe association prenatal levels proinflammatory C-reactive protein (CRP) and interleukin-8 (IL-8) with participants Vitamin D Antenatal Asthma Reduction Trial. Study Design Five hundred twenty-eight patients available samples both first- third-trimester plasma were included this analysis. CRP IL-8 measured...
Abstract Introduction The impulse oscillometry (IOS) indices absolute and relative difference between respiratory resistance at 5 20 Hz (R5‐20 R5‐20%, respectively) the area under reactance curve (AX) are postulated to reflect small airway function. Data on their cutoff values evaluate bronchodilator responsiveness (BDR) or between‐visit changes after interventions limited in young children. Methods We evaluated BDR of 103 healthy children aged 2‐7 years, who received either salbutamol ( n =...
Patients are surviving decades after congenital heart surgery (CHS), raising the importance of postoperative quality life as an outcome measure. We determined long-term social outcomes CHS performed during childhood.Between 1953 and 2009, 10 635 patients underwent for defects at <15 years age in Finland. obtained 4 control subjects per patient, matched by age, sex, birth time, hospital district, from Statistics Finland, which also provided data on highest education level, employment status,...
Abstract Background Lung function impairment among asthmatic children begins in early life, and biomarkers for identifying this are needed. The chitinase‐like protein YKL‐40 has been associated with asthma lung adults, but studies have yielded conflicting results. We evaluated the potential of other systemic deficits symptoms. Methods determined levels serum YKL‐40, periostin, high‐sensitivity C‐reactive (hs‐CRP) from blood samples 49 was assessed impulse oscillometry (IOS) spirometry,...
Preeclampsia has been associated with maternal epigenetic changes, in particular DNA methylation changes the placenta. It suggested that preeclampsia could also cause neonate. We examined relation to gene expression cord blood of offspring born mothers preeclampsia.
The biochemical mechanisms underlying lung function are incompletely understood.
We evaluated whether the administration of sildenafil in children undergoing TCPC operation shortened interval from to removal pleural and peritoneal drains.We retrospectively reviewed data 122 patients who had undergone between 2004 2014. Patients were divided into two groups on basis their treatments. Sildenafil was orally administered pre-operatively morning procedure or within 24 hours after group (n = 48), which compared a control 60). Fourteen excluded study.The primary outcome measure...
Abstract Background The use of component‐resolved allergy diagnostics has provided a clearer understanding the species‐specific sensitization and severity potential allergic reactions. This cross‐sectional study aimed to determine whether allergen components in furry animals is indicative blood eosinophilia, positive fractional exhaled nitric oxide (FeNO) test, abnormal lung function, asthma symptoms children. Additionally, we investigated having pets during childhood affects development or...
In this retrospective study we investigated risk factors for impaired lung function based on medical records of asthmatic children treated in a tertiary hospital between October 2004 and December 2008. Baseline characteristics, measurements current medication were charted. Those 430 with data ≥2 performed ≥5 years apart, included the analyses. Altogether 91 (21%) had abnormal findings first measurement (n=38/265 oscillometry at median age 4.2 years, n=53/165 spirometry 7.6 years) 183 (43%)...
<b>Background:</b> Impulse oscillometry (IOS) is feasible for preschool children and postulated to enable assessment of small airways function. Yet, limited data on the repeatability IOS in young exist. <b>Aims:</b> To clarify within- between-visit healthy symptomatic children, with special regard putative indices function: difference between respiratory resistance at 5 20 Hz (R5-20) area under reactance curve (AX). <b>Methods:</b> We retrospectively analysed within-measurement triplicate...