A5101502717- Asthma and respiratory diseases
- Mobile Health and mHealth Applications
- Respiratory and Cough-Related Research
- Child and Adolescent Health
- Kawasaki Disease and Coronary Complications
- Emergency and Acute Care Studies
- Streptococcal Infections and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Impact on Reproduction
- Antimicrobial Resistance in Staphylococcus
- Coronary Artery Anomalies
- Pregnancy and Medication Impact
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Neonatal Respiratory Health Research
- Metabolomics and Mass Spectrometry Studies
- Technology Use by Older Adults
- Cardiovascular Issues in Pregnancy
- Neonatal and Maternal Infections
- Delphi Technique in Research
- Pneumonia and Respiratory Infections
- Childhood Cancer Survivors' Quality of Life
- Spinal Fractures and Fixation Techniques
- Health Literacy and Information Accessibility
- Fungal and yeast genetics research
University of Toledo
2019-2025
Mount Sinai Hospital
2025
The University of Melbourne
2016-2024
Murdoch Children's Research Institute
2016-2024
Royal Children's Hospital
2016-2024
Universitätsklinikum Krems
2024
University of California, San Francisco
2023
General Department of Preventive Medicine
2023
University of California, San Diego
2015-2022
University of California, Berkeley
2020
Malignant mesothelioma (MM) is an aggressive tumor arising from mesothelial linings of the serosal cavities. Pleural space most common site, accounting for about 80% cases, while peritoneum makes up majority remaining 20%. While histologically similar, tumors these sites are epidemiologically and clinically distinct their attribution to asbestos exposure differs. We compared DNA array-based findings 48 epithelioid peritoneal MMs 41 pleural identify similarities differences in copy number...
The incidence of type 2 diabetes is increasing more rapidly in adolescents than any other age group. We identified and compared metabolite signatures obese children with (T2D), without (OB), healthy, age- gender-matched normal weight controls (NW) by measuring 273 analytes fasting plasma 24-hour urine samples from 90 subjects targeted LC-MS/MS. Diabetic were within years diagnosis an attempt to capture early-stage disease prior declining renal function. found 22 metabolites that uniquely...
Study Design: This is a retrospective cohort analysis of patient’s identified with short cervix (<2.5cm) at the time their anatomic survey ultrasound between 16-24 weeks gestation. Patient’s demographic data including race and ethnicity were collected in addition to cervical lengths throughout pregnancy gestational age delivery. Short delivery compared racial groups. Results: 351 patients cervixes our study. Among those cervix, there was no statistical significance White (p=0.66, 95% CI =...
Background There are limited data describing the epidemiology, management and outcomes of children with toxic shock syndrome (TSS), a potentially life-threatening illness. Here, we describe incidence, clinical features, treatment outcome staphylococcal streptococcal TSS in Victoria, Australia. Methods Retrospective chart review admitted between 2003 2014 to two tertiary paediatric referral centres who fulfilled Centers for Disease Control Prevention case definition TSS. Results were 62 cases...
Abstract Objective To identify concerns, barriers and facilitators impacting the use of patient portals by older patients as well desired features in future updates. Materials Methods This is a cross-sectional study consisting 2 focus group discussions culminating an anonymous survey administered to women who were 65 years receiving urogynecologic care Northwest Ohio. Results Of 205 surveyed (91% response rate), providers healthcare systems play primary roles (73% 69%, respectively)...
The pathogenesis of Kawasaki disease (KD) remains unknown and there is accumulating evidence for the importance innate immune system in initiating mediating host inflammatory response. We compared responses KD toxic shock syndrome (TSS) participants more than two years after their acute illness with control to investigate differences phenotype. Toxic shares many clinical features KD; by including both groups we endeavoured explore changes following illnesses broadly. measured vitro...
Cervical alignment has become increasingly important in the planning of spine surgery. A relationship between slope T1 (T1S), cervical lordosis (CL), and overall sagittal vertical axis (cSVA) previously been demonstrated, but exact nature this is poorly understood. In study, we derive theoretical empirical equations to better understand how T1S CL affect cSVA. The first equation was developed on a basis using inherent trigonometric relationships spine. By treating as arc circumference, by...
The purpose of this study was to determine the predictors and outcomes pregnant women with vaginal-rectal carriage community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). We performed an unmatched 1:4 case-control two control groups (13 CA-MRSA cases, 52 methicillin-sensitive S. (MSSA) controls, aureus-negative controls) via a retrospective medical record review. found that cases were 12.5 times significantly less likely be colonized group B streptococci (GBS) compared...
Abstract Background Asthma is the most common chronic respiratory illness among children in Australia. While childhood asthma prevalence varies by region, little known about variations at small geographic area level. Identifying critical for highlighting hotspots targeted interventions. This study aimed to investigate area-level variation, spatial clustering, and sociodemographic risk factors associated with Methods Data on self-reported (by parent/carer) aged 0–14 years statistical level 2...
Self-quantifying fitness tracking services and wearable devices have become more ubiquitous but still suffer from high abandonment rates. Wearable can monitor the physiological changes of body alert patients physicians immediate needed actions facilitate in research process disease prevention treatment, especially areas that less access to healthcare. This proceeding discusses how bridge gap between novice expert users by implementing gamification techniques social communities within...
Variation in healthcare delivery is increasingly recognized as an important metric of quality. Directly observed therapy (DOT) has been the standard care for tuberculosis (TB) treatment supervision decades based on World Health Organization (WHO) guidelines. However, variation implementation DOT and associated TB practices remains poorly defined.We collected individual patient data from registers at 18 units Uganda including District Centers, Hospitals, Regional Referral Hospitals. We also...
Abstract It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and associated traditional risk factors events. aim of this study was to investigate microvascular parameters two populations patients previous KD control participants. We performed case-control studies 116 (57 59 participants) Australian 156 (78 78 Singaporean individuals, at least years since their acute...
A needs assessment was conducted of hepatitis B education, screening, vaccination, and care within community health centers (CHCs) serving Asian Americans, Native Hawaiians, Pacific Islanders.Written surveys were administered to education directors from 13 CHCs 75 medical providers 14 in the U.S. affiliated Islands.Although is mission clients are screened regardless insurance status, little financial or staffing resources dedicated services. Lack funding considered greatest barrier. Better...
Highly inbred C57BL/6 mice show wide variation in their degree of insulin resistance response to diet-induced obesity even though they are almost genetically identical. Here we employed transcriptional profiling by RNA sequencing (RNA-Seq) visceral adipose tissue (VAT) and liver young determine how gene expression patterns correlate with the later development high-fat diet (HFD)-induced adulthood. To accomplish this goal, partially removed banked tissues from pubertal mice. Mice subsequently...
To study total growth, rate of bone maturation, and menarche after discontinuation Gonadotropin releasing hormone agonist (GnRHa) treatment for central precocious puberty (CPP).Twenty girls with CPP on GnRHa were followed from to final height (FH). Height, velocity (HV), age measured every 6 months. Age at was collected.Once is discontinued, maturation (bone [BA]/chronological [CA]) accelerated 0.7 ± 0.3 end 1.2 0.8 post treatment, similar BA/CA prior treatment. BA ranged 11-14 years. On...
Explore gaps and opportunities in primary care for children following a hospital admission asthma.Exploratory mixed-methods, using linked administration data.Eligible children, aged 3-18 years, admitted to one of three hospitals Victoria, Australia between 2017 2018 with clinical diagnosis asthma.767 caregivers eligible participated, 39 completed semistructured interview 277 general practitioners (GPs) caring 360 survey. Over 90% (n=706) reported their child had regular GP. However, few...
INTRODUCTION: Identification and Rating of Gynecologic Oncology Applications Using the APPLICATIONS Scoring System. METHODS: A list non-consumer gyn-onc apps was identified from Apple iTunes Google Play Stores. Based on reliable references, inaccurate were excluded. The remaining rated with scoring system, which uses both objective subjective measures. RESULTS: Of 748 identified, 11 (1.5%) found to be useful accurate providers. lowest scores calculator while those highest informational apps....
Docosahexaenoic acid (DHA 22:6n-3) and salicylate are both known to exert anti-inflammatory effects. This study investigated the effects of a novel bifunctional drug compound consisting DHA linked together by small molecule that is stable in plasma but hydrolyzed cytoplasm. The components acted synergistically reduce inflammation mediated via nuclear factor κB cultured macrophages. Notably, oral administration two distinct ways mitigate hyperglycemia high-fat diet-induced insulin resistance....
Objectives To (1) describe the dispensing of asthma preventers at hospital discharge and estimate its effect on readmissions, (2) community preventer readmissions for subgroup children who were not prescribed an discharge. Design Multisite cohort study with linked administrative data. Participants Children aged 3–18 years admitted to a tertiary paediatric, mixed paediatric adult, or regional between 2017 2018. Main outcome measure Hospital readmission within 12 months. Results Of 767...