A5005908657- Congenital Heart Disease Studies
- Birth, Development, and Health
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Coronary Artery Anomalies
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Cardiovascular Issues in Pregnancy
- Cardiac Imaging and Diagnostics
- Respiratory viral infections research
- Cardiac Structural Anomalies and Repair
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Infective Endocarditis Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Congenital Diaphragmatic Hernia Studies
- Obesity, Physical Activity, Diet
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Kawasaki Disease and Coronary Complications
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular Conditions and Treatments
Thomas Jefferson University Hospital
2022-2025
Royal Children's Hospital
2015-2024
Murdoch Children's Research Institute
2015-2024
The University of Melbourne
2014-2024
Bristol-Myers Squibb (United States)
2024
Morristown Medical Center
2024
Atlantic Health System
2024
Seqirus (United States)
2023
Thomas Jefferson University
2022
Oracle (United States)
2022
The incidence and age distribution of primary cardiomyopathy in children are not well defined. We undertook a population-based, retrospective cohort study Australia to document the epidemiology childhood cardiomyopathy.
Background— We have demonstrated that myocardial acceleration during isovolumic contraction (IVA) is a sensitive index of left ventricular contractile function. In this study, we assessed the utility IVA to measure right (RV) Methods and Results— examined 8 pigs by using tissue Doppler imaging RV free wall simultaneous measurements intraventricular pressure, volume, maximal elastance (e max ), preload recruitable stroke work, dP/dt conductance catheterization. Animals were paced in atrium at...
Background— Despite considerable mortality, population-based prognostic factors for childhood dilated cardiomyopathy are lacking. Methods and Results— A cohort study was undertaken of all children in Australia who presented with at age 0 to 10 years between January 1, 1987, December 31, 1996. single cardiologist analyzed cardiac investigations, a pathologist histopathological material. There were 184 subjects cardiomyopathy. Positive viral identification or lymphocytic myocarditis found 30...
Remote ischemic preconditioning reduces myocardial infarction (MI) in animal models. We tested the hypothesis that systemic protection thus induced is effective when administered during ischemia (PerC) and before reperfusion examined role of K + -dependent ATP (K ) channel. Twenty 20-kg pigs were randomized (10 each group) to 40 min left anterior descending coronary artery occlusion with 120 reperfusion. PerC consisted four 5-min cycles lower limb by tourniquet occlusion. Left ventricular...
A high childhood body mass index (BMI) is associated with a risk of obesity in adulthood. Several studies have shown adverse long-term outcomes childhood, including type 2 diabetes mellitus and cardiovascular disease. It unclear whether increased as an adult predetermined consequence or these effects can be reversed obese children who become nonobese adults. This observational study was designed to compare the disease among adults without history overweight during childhood. Data were pooled...
Background— Population-based studies have provided insight into the natural history of adult hypertrophic cardiomyopathy, but comparable information for affected children is lacking. Methods and Results— All Australian who presented with primary cardiomyopathy at 0 to 10 years age between January 1, 1987, December 31, 1996, were enrolled in a longitudinal cohort study. A single cardiologist reviewed serial cardiac investigations on each subject. total 80 subjects identified. An underlying...
Abstract More than 7 million individuals have been conceived by Assisted Reproductive Technologies (ART) and there is clear evidence that ART associated with a range of adverse early life outcomes, including rare imprinting disorders. The periconception period embryogenesis are widespread epigenetic remodeling, which can be influenced ART, effects on the developmental trajectory in utero, potentially health throughout life. Here we profile genome-wide DNA methylation blood collected newborn...
Stroke is among the top 10 causes of death in children and survivors carry resulting disabilities for decades, at substantial cost to themselves their families. Children are not currently able access reperfusion therapies, due limited evidence supporting safety efficacy long diagnostic delays. The Australian Clinical Consensus Guideline Diagnosis Acute Management Childhood was developed minimize unwarranted variations care document best on risk factors, etiologies, conditions mimicking...
AimThe myocardial performance index (MPI), or Tei index, has been shown to be useful in the assessment of global performance. There are few invasive data however, which examine its load dependence sensitivity acute changes contractile function. The purpose this study was therefore formally effect clinically relevant these parameters an animal model.
Hypertension may be predicted from childhood risk factors. Repeated observations of abnormal blood pressure in enhance prediction hypertension and subclinical atherosclerosis adulthood compared with a single observation. Participants (1927, 54% women) the Cardiovascular Risk Young Finns Study had systolic diastolic measurements performed when aged 3 to 24 years. Childhood/youth was defined as above 90th or 95th percentile. After 21- 31-year follow-up, at age 30 45 years, (>140/90 mm Hg...
Aim The coronavirus (COVID‐19) pandemic has led to increased concerns about adolescent mental health. This study aimed determine the effect of on eating disorders (EDs) by measuring changes in number and severity presentations an Australian paediatric ED service that utilises a standardised approach triage assessment. Methods A 4‐year retrospective chart review (2017–2020) all patients ( n = 457) presenting Royal Children's Hospital Eating Disorder Service, Melbourne, was undertaken....
Video-assisted thoracic surgery (VATS) is an established treatment for recurrent or complicated primary spontaneous pneumothorax (PSP). However, a proportion of patients still complains chronic pain discomfort after VATS pleurodesis. We aimed to investigate if paresthesia distinct component the post-operative in receiving PSP.Telephone interviews were conducted with 52 who had received pleurodesis PSP our institute during defined 24 month period. A standardized questionnaire was used...
Physical fitness is known to influence arterial stiffness. Resting heart rate reduced by exercise and positively associated with This study aimed investigate the role of resting in relationship physical Subjects were 2,328 young adults from Childhood Determinants Adult Health study. Cardiorespiratory was estimated as work capacity at a 170 bpm. Muscular strength hand-grip (both sides), shoulder (pull push), leg strength. Arterial stiffness measured using carotid ultrasound. negatively...
Summary Background Excess adiposity and adiposity‐related inflammation are known risk factors for cardiovascular disease in adults; however, little is regarding the determinants of at birth. Objectives The aim this study was to investigate association between maternal pre‐pregnancy BMI newborn inflammation. Methods Paired (28‐week gestation) infant (umbilical cord) blood samples were collected from a population‐derived birth cohort (Barwon Infant Study, n = 1074). Data on comorbidities...
Long-term outcomes for childhood left ventricular noncompaction (LVNC) are uncertain. We examined late children with LVNC enrolled in a national population-based study.The National Australian Childhood Cardiomyopathy Study includes all Australia primary cardiomyopathy diagnosed before 10 years of age between 1987 and 1996. Outcomes subjects dilated phenotype (LVNC-D) were compared those cardiomyopathy. Propensity-score analysis was used risk factor adjustment.There 29 (9.2% subjects), mean...
OBJECTIVES: To examine how overweight and obesity at specific ages overall BMI growth patterns throughout childhood predict cardiometabolic phenotypes 11 to 12 years. METHODS: In a population-based sample of 5107 infants, was measured every 2 years between 3 10 We identified 5 trajectories using curve models. At years, 1811 children completed assessments for metabolic syndrome risk scores, carotid-femoral pulse wave velocity, carotid intima-media thickness. Multivariable regression models...
Respiratory syncytial virus (RSV) has been reported to infect human mesenchymal stem cells (MSCs) but the consequences are poorly understood. MSCs present in nearly every organ including nasal mucosa and lung play a role regulating immune responses mediating tissue repair. We sought determine whether RSV infection of enhances their regulatory functions contributes RSV-associated disease. was shown replicate by fluorescence microscopy, plaque assay, expression transcripts. RSV-infected showed...
Socioeconomic disadvantage throughout the life course is associated with increased risk of cardiometabolic diseases, but traditional factors do not fully account for social gradient. We investigated interactions between low socioeconomic status (SES) and infection in childhood adverse parameters adulthood.Participants from Cardiovascular Risk Young Finns Study, a cohort well phenotyped adulthood parameters, were linked to lifetime hospitalization data birth onward available Finnish National...