A5074857565- Thyroid Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Nitric Oxide and Endothelin Effects
- Thyroid Cancer Diagnosis and Treatment
- Redox biology and oxidative stress
- Diabetes and associated disorders
- Digestive system and related health
- Erythrocyte Function and Pathophysiology
- Inflammatory mediators and NSAID effects
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Glutathione Transferases and Polymorphisms
- Abdominal Trauma and Injuries
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Birth, Development, and Health
- Metastasis and carcinoma case studies
- Caveolin-1 and cellular processes
- Peripheral Neuropathies and Disorders
- Enzyme Production and Characterization
- Respiratory Support and Mechanisms
- Cardiac Arrhythmias and Treatments
- Eicosanoids and Hypertension Pharmacology
- Bariatric Surgery and Outcomes
UCLouvain
2007-2023
Hôpital de Jolimont
2020-2023
University of Alabama at Birmingham
2022
Society of Critical Care Medicine
2021
Centre Hospitalier Chrétien
2018
Morpho (United States)
2009
Institut de Biologie de Lille
2008
Centre Hospitalier Régional et Universitaire de Nancy
1982
Centre de Médecine Préventive
1981
<h3>Importance</h3> Obesity, diabetes, and hypertension are common comorbidities in patients with severe COVID-19, yet little is known about the risk of acute respiratory distress syndrome (ARDS) or death COVID-19 metabolic syndrome. <h3>Objective</h3> To determine whether associated an increased ARDS from COVID-19. <h3>Design, Setting, Participants</h3> This multicenter cohort study used data Society Critical Care Medicine Discovery Viral Respiratory Illness Universal Study collected 181...
In basal conditions, thyroid epithelial cells produce moderate amounts of reactive oxygen species (ROS) that are physiologically required for hormone synthesis. They not necessarily toxic because they continuously detoxified either in the process synthesis or by endogenous antioxidant systems. Using a rat model goiter formation and iodine-induced involution, we found compared with control thyroids, oxidative stress, assessed detection 4-hydroxynonenal, was strongly enhanced both hyperplastic...
Summary Aims Using the novel FreeStyle Libre ( FSL ), glucose monitoring FGM ) system becomes increasingly popular among people with type 1 diabetes (T1D) and is associated less shorter hypoglycaemic events without deterioration of HbA1c. There are not yet data reporting impact in T1D real‐life conditions. We sought evaluating tolerance, acceptance efficacy routine medical practice. Methods This 12‐month observational study included 120 individuals evaluated every 3 months. After having been...
Progress in biotechnology has provided useful tools for tracing proteins involved thyroid hormone synthesis vivo. Mono- or polyclonal antibodies are now available to detect on histological sections the Na(+)/I(-) symporter (NIS) at basolateral pole of cell, putative iodide channel (pendrin) apical plasma membrane, thyroperoxidase (TPO), and members NADPH-oxidase family, oxidase 1 2 (ThOXs), part H(2)O(2)-generating system. The aim this study was correlate thyroglobulin (Tg) iodination with...
Hashimoto's thyroiditis (HT) and Graves' disease (GD) are thyroid autoimmune disorders driven by Th1 Th2 immune responses, respectively. Caveolin-1 (Cav-1), peroxidase (TPO), dual oxidase (DUOX) thought to be part of the thyroxisome, which is essential maintain hormone synthesis, at apical membrane. To analyze thyroxisome in HT GD thyroids, we investigated Cav-1, DUOX, TPO expression as well markers oxidative stress (OS), cell proliferation, apoptosis, antioxidant defenses. The effects...
Providing analgesia and sedation is an essential component of caring for many mechanically ventilated patients. The selection analgesic sedative medications during the COVID-19 pandemic, impact these practices on patient outcomes, remain incompletely characterized.
In human thyroid, caveolin-1 is localized at the apex of thyrocytes, but its role there remains unknown. Using immunohistochemistry, (127)I imaging, transmission electron microscopy, immunogold and quantification H(2)O(2), we found that in knockout mice thyroid cell homeostasis was disrupted, with evidence oxidative stress, damage, apoptosis. An even more striking phenotype absence thyroglobulin iodine one-half follicular lumina their presence cytosol, suggesting iodide organification...
Pendred syndrome is caused by mutations in the gene coding for pendrin, an apical Cl-/I- exchanger.To analyze intrathyroidal compensatory mechanisms when pendrin lacking, we investigated thyroid of a patient with syndrome. The expression proteins involved hormone synthesis, markers oxidative stress (OS), cell proliferation, apoptosis, and antioxidant enzymes were analyzed.Three morphological zones identified: nearly normal follicles iodine-rich thyroglobulin colloid (zone 1.a), small without...
In animals, as well in humans, the thyroid gland is made of active follicles, with cuboidal cells and hypofunctioning flattened cells. this study, functional status human follicles was dissected out, based on immunohistochemical detection TSH receptor, Na+/I− symporter, pendrin, thyroperoxidase (TPO), oxidases (ThOXs), T4-containing iodinated Tg (Tg-I). To ascertain that angiofollicular units exist human, we studied microvascular bed each follicle, correlation vascular endothelial growth...
Peroxiredoxin 5 (PRDX5) is a newly discovered thioredoxin peroxidase able to reduce peroxides that implicated in antioxidant protective mechanisms. We report here its expression the human thyroid gland. Twentyseven specimens were examined by immunohistochemistry. They included six normal tissues, five multinodular goiters, nine hot nodules, two Hürthle cell adenomas, and thyroids from patients with Graves' disease. In control tissue, PRDX5 was heterogeneous, being stronger cubical...
Background: Angiogenesis plays an essential role in embryonic and tumoral developments. Vascular endothelial growth factor (VEGF), one of the best known proangiogenic factors, is increased thyroid cancers, especially papillary carcinomas (PC). However, other regulating mechanisms refine VEGF-induced cellular changes, such as Notch family ligands receptors. Their has not yet been investigated thyroid. The purpose our study was to analyze expression Notch1, Notch4, Delta-like 4 (DLL4) benign...
In addition to reactive oxygen species (ROS) produced by mitochondria during aerobic respiration, thyrocytes are continuously producing H 2 O , a key element for hormonogenesis. Because nothing is known about ROS implication in normal non-stimulated cells, we studied their possible involvement incubated with potent antioxidant, N -acetylcysteine (NAC). NAC, which blocked the production of intracellular ROS, also decreased dual oxidases, thyroperoxidase, pendrin, and thyroglobulin protein...
Vascular supply is an obvious requirement for all organs. In addition to oxygen and nutrients, blood flow also transports essential trace elements. Iodine, which a key element in thyroid hormone synthesis, one of them. An inverse relationship exists between the expansion microvasculature local availability iodine. This microvascular element-dependent regulation unique contributes keep steady iodide delivery thyroid. Signals involved this regulation, such as VEGF-A, originate from thyrocytes...
Vitamin D is known to modulate thyroid neoplastic and autoimmune disease. We investigated the role of vitamin receptor (VDR) in normal development function (thyrocytes C cells).The phenotype VDR knockout mice was studied comparison wild-type controls. The were fed a diet or calcium-rich circumvent effects induced by hypocalcemia.Thyroid morphology unaltered mice. Also, expression different parameters thyrocyte comparable (immunohistochemistry). cell physiology was, however, affected absence...
Morphological and functional alterations in Hashimoto's thyroiditis (HT) are predominantly mediated by Th1 cytokines through apoptotic cell death. This ultimate step could be preceded injuries thyroid hormone synthesis. The action of two (IL-1alpha/IFN-gamma) on thyroperoxidase (TPO) oxidase (ThOXs) expression was tested human thyrocytes isolated from normal tissues, Graves' disease (GD) autonomous toxic nodules. There no evidence Nitric oxide (NO) release induced but absent when...
Background: Th1 cytokines exert pleiotropic effects in Hashimoto's thyroiditis. Previous studies reported a downregulation of thyroperoxidase and dual oxidase (DUOX) protein mRNA expression thyroid cells treated with cytokines. Although this effect is partially mediated by intracellular reactive oxygen species (ROS) nitrogen species, the nature source ROS involved are currently unknown. The aim study was to examine further produced response Methods: Two rat cell lines (PCCL3 FRTL-5) human...
Iodine deficiency (ID) induces microvascular changes in the thyroid gland via a TSH-independent reactive oxygen species-hypoxia inducible factor (HIF)-1α-vascular endothelial growth (VEGF) pathway. The involvement of nitric oxide (NO) this pathway and role calcium (Ca2+) ryanodine receptors (RYRs) NO synthase 3 (NOS3) activation were investigated murine model goitrogenesis vitro models ID, including primary cultures human thyrocytes. ID activated NOS3 production thyrocytes increased blood...
Hypothyroidism, together with glandular atrophy, is the usual outcome of destructive autoimmune thyroiditis. The impairment in thyroid function results either from cell destruction or Th1 cytokine-induced alteration hormonogenesis. Here, we investigated impact local immune context on function. We used two rat lines (PCCL3 and FRTL-5) human thyrocytes incubated IL-1α/interferon (IFN) γ IL-4, a Th2 cytokine, TGF-β, IL-10, Th3 cytokines. first observed that IL-4 totally blocked γ-induced dual...