A5015728089- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Palliative Care and End-of-Life Issues
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Family and Patient Care in Intensive Care Units
- Cardiac Arrest and Resuscitation
- Adrenal Hormones and Disorders
- Clinical Nutrition and Gastroenterology
- Airway Management and Intubation Techniques
- Clinical Reasoning and Diagnostic Skills
- Healthcare cost, quality, practices
- Asthma and respiratory diseases
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Emergency and Acute Care Studies
- Mechanical Circulatory Support Devices
- Nosocomial Infections in ICU
- Geriatric Care and Nursing Homes
- Healthcare Policy and Management
- Sarcoidosis and Beryllium Toxicity Research
- Nutrition and Health in Aging
- Blood transfusion and management
- Hemoglobinopathies and Related Disorders
Boston University
2019-2025
Pulmonary Associates
2022-2025
Beth Israel Deaconess Medical Center
2016-2024
Boston Medical Center
2023-2024
Johns Hopkins University
2024
Deaconess Hospital
2020-2024
Pulmonary and Allergy Associates
2023
University of Alabama at Birmingham
2022
Providence College
2021
Rhode Island College
2021
This document updates previously published Clinical Practice Guidelines for the management of patients with acute respiratory distress syndrome (ARDS), incorporating new evidence addressing use corticosteroids, venovenous extracorporeal membrane oxygenation, neuromuscular blocking agents, and positive end-expiratory pressure (PEEP).
This study assesses changes in COVID-19 vaccination rates before and after the Ohio vaccine lottery announcement compared with national to control for expansion of indications adolescents.
Importance Patients with septic shock may benefit from the initiation of corticosteroids. However, comparative effectiveness 2 most studied corticosteroid regimens (hydrocortisone fludrocortisone vs hydrocortisone alone) is unclear. Objective To compare adding to alone among patients using target trial emulation. Design, Setting, and Participants This retrospective cohort study 2016 2020 used enhanced claims-based Premier Healthcare Database, which included approximately 25% US...
Despite our increasingly sophisticated understanding of transcriptional regulation in pancreas development, we know relatively little about the extrinsic signaling pathways involved this process. We show here that early pancreatic epithelium exhibits a specific enrichment unphosphorylated beta-catenin protein, hallmark activation canonical Wnt pathway. To determine if pathway is functionally required for normal have specifically deleted gene these cells. Pancreata developing without are...
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In trial, patients randomly allocated 1:1 to either or intensive medical therapies (standard care). We conducted planned analyses 6 months, including all 155 patients. measured functional using Glasgow Outcome Scale-Extended (GOS-E). used ordered logistic regression, dichotomized GOS-E...
Importance Thyroid storm is the most severe form of thyrotoxicosis, with high mortality, and treated propylthiouracil methimazole. Some guidelines recommend over methimazole, although difference in outcomes associated each treatment unclear. Objective To compare use vs methimazole for thyroid storm. Design, Setting, Participants This comparative effectiveness study comprised a large, multicenter, US-based cohort from Premier Healthcare Database between January 1, 2016, December 31, 2020. It...
Lottery-Based Incentives and COVID-19 Vaccination Rates in the USOn May 12, 2021, Ohio announced a lottery system incentivizing residents to receive vaccinations 1 ; several US states subsequently introduced similar programs. 2Although analysis of vaccination rates from suggested that lotterybased incentives were not associated with increased rates, 3 responses programs across other are unclear.In this study, we assessed changes lottery-based vaccine incentives.
Uncertainty remains regarding the risks associated with single-dose use of etomidate.
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible cause of dementia and gait disturbance that typically treated by operative placement ventriculoperitoneal shunt. The outcome from shunting variable, some evidence suggests the presence comorbid Alzheimer's disease (AD) may impact shunt outcome. Evidence also AD biomarkers in cerebrospinal fluid (CSF) predict AD. aim this study was to investigate relationship between phosphorylated tau/amyloid beta 1-42 (ptau/Aβ1-42)...
: Rationale The comparative effectiveness of biologics used as add-on therapy in the management difficult-to-control asthma is unclear. Objective To compare dupilumab, mepolizumab and benralizumab among patients with asthma. Methods Retrospective multicenter cohort study adult started on or from a electronic health record claims-based database between October 19, 2018 September 30, 2022. Propensity score matching was to minimize bias non-randomized treatment assignment; prespecified alpha...
In-hospital mortality of patients with sepsis is frequently measured for benchmarking, both by researchers and policymakers. Prior studies have reported higher in-hospital among at safety-net hospitals compared non-safety-net hospitals; however, in critically ill patients, rates are known to be associated hospital discharge practices, which may differ between hospitals.
Acute Respiratory Distress SyndromeAcute respiratory distress syndrome (ARDS) is a sudden and dangerous illness that makes it difficult to get enough oxygen.
A large multicenter retrospective study was conducted to examine practice patterns in the care of severe acute asthma PICUs compared with adult ICUs. Eligible patients were 12-26 y old, admitted a PICU or an ICU asthma, and received noninvasive ventilation mechanical ventilation. Multiple medication prescribing examined. 3,361 total included: 583 (17.3%) 2,778 (82.7%) Significantly more parenteral terbutaline (25.7% vs. 10.2%, standard mean differences = 0.412) than those Admission for...