A5006998717- Pharmaceutical Practices and Patient Outcomes
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Patient Safety and Medication Errors
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Innovations in Medical Education
- Cardiac Arrest and Resuscitation
- Machine Learning in Healthcare
- Pharmacy and Medical Practices
- Anesthesia and Sedative Agents
- Health and Medical Research Impacts
- Artificial Intelligence in Healthcare and Education
- Renal function and acid-base balance
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- Health Sciences Research and Education
- Healthcare professionals’ stress and burnout
- Diversity and Career in Medicine
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Clinical Reasoning and Diagnostic Skills
- Antibiotic Use and Resistance
- Electrolyte and hormonal disorders
Augusta University
2012-2025
Georgia College & State University
2017-2025
University of Georgia
2012-2025
Augusta University Health
2017-2025
University of Colorado Denver
2025
University of Virginia
2024
Franklin College
2024
Duke University
2024
Emory University
2022-2024
Brigham and Women's Hospital
2024
Despite the established role of critical care pharmacist on ICU multiprofessional team, workloads are likely not optimized in ICU. Medication regimen complexity (as measured by Regimen Complexity-ICU [MRC-ICU] scoring tool) has been proposed as a potential metric to optimize workload but lacked robust external validation. The purpose this study was test hypothesis that MRC-ICU is related both patient outcomes and interventions diverse population.This multicenter, observational cohort...
Minocycline is under investigation as a neurovascular protective agent for stroke. This study evaluated the pharmacokinetic, anti-inflammatory, and safety profile of minocycline after intracerebral hemorrhage.This was single-site, randomized controlled trial conducted from 2013 to 2016. Adults ≥18 years with primary hemorrhage who could have drug administered within 24 hours onset were included. Patients received 400 mg intravenous minocycline, followed by oral daily 4 days. Serum...
What gets measured, improved. —Robert Sharma Every critically ill patient requires care by a critical pharmacist (CCP) for best possible outcomes. Indeed, these highly trained professionals generate benefit through direct (eg, pharmacist-driven protocols, medication monitoring, etc), participation on the intensive unit (ICU) interprofessional team pharmacotherapy recommendations, education, and leadership in development implementation of quality improvement initiatives.1 However, clinical...
Purpose: ASHP Residency Standards consider research an important component of residency training. Publication these projects is considered the gold standard for high quality research; however, publication rates are low, with most reports suggesting less than 12% successfully published. This study reviewed post-graduate year one (PGY1) to evaluate role mentorship in successful peer-reviewed journals. Summary: was a single-center, observational PGY1 between 2010 and 2022 assess mentorship’s...
The purpose of this study was to develop and validate a novel medication regimen complexity-intensive care unit (MRC-ICU) scoring tool in critically ill patients correlate MRC with illness severity patient outcomes.This single-center, retrospective observational chart review adults admitted the medical ICU (MICU) between November 2016 June 2017. primary aim development internal validation MRC-ICU tool. Secondary aims included external exploration relationships complexity outcomes. Exclusion...
Intravenous fluids (IVFs) are the most common drugs administered in intensive care unit. Despite ubiquitous use, IVFs not benign and carry significant risks associated with under- or overadministration. Hypovolemia is decreased organ perfusion, ischemia, multi-organ failure. Hypervolemia volume overload dysfunction, delayed liberation from mechanical ventilation, increased mortality. appropriate provision of IVF, adverse drug effects such as electrolyte abnormalities acid–base disturbances...
Abstract Introduction Pharmacists are widely recognized members of the critical care health team. However, unlike other professions, pharmacists do not have standardized pharmacist to patient ratios that establish maximal cost‐efficiency while maintaining optimal safety. Though many prior recommendations claim a ratio 1:15 for safe pharmacy practice, ranged as low 1:8 high 1:30. Objectives To determine pharmacists' perceptions within intensive unit (ICU) and qualitatively quantitatively...
Abstract Background Clinical pharmacists are established members of the interprofessional patient care team, but limited guidance for optimal utilization pharmacy resources is available. Objective measurement medication regimen complexity offers a novel process evaluating pharmacist activity. The purpose this study was to evaluate relationship between complexity, as measured by scoring tool (MRC‐ICU), and both interventions drug‐drug interactions (DDIs). Methods This multi‐center,...
<b>Objective.</b> To develop, implement, and assess student performance confidence in a pharmacy capstone course that used case-based instruction the Pharmacist's Patient Care Process (PPCP) to develop patient work-up skills third-year Doctor of Pharmacy (PharmD) students. <b>Methods.</b> A skills-based was developed by team faculty members instructional designers focused on evaluation applying steps PPCP complex cases housed simulated electronic health record (SEHR). The acuity increased...
The purpose of this study was to characterize dynamic changes in medication regimen complexity over time critically ill adults and validate a modified version the complexity-intensive care unit (MRC-ICU) scoring tool.A single-center, retrospective, observational chart review conducted with primary aim assessing time, as measured by both 39-item MRC-ICU tool (the mMRC-ICU) containing just 17 items. Secondary aims included validation mMRC-ICU exploration relationships between ICU length stay...
The Medication Regimen Complexity -Intensive Care Unit (MRC-ICU) is the first tool for measuring medication regimen complexity in critically ill patients. This study tested machine learning (ML) models to investigate relationship between and patient outcomes.This was a single-center, retrospective observational evaluation of 130 adults admitted medical ICU. MRC-ICU score utilized improve inpatient model's prediction accuracy. Three were proposed: model I, demographic data without data; II,...
Abstract Purpose Critical care pharmacy services have progressed since their origination in the 1970s and been supported by a position paper that categorized these as fundamental (eg, provides drug information to critical team), desirable responds resuscitation events hospital), optimal publishes clinical research peer‐reviewed journals). Burnout syndrome is serious problem with far‐reaching consequences may be heightened demanding nature of care. The purpose this study was explore...
Background: Critically ill patients are at increased risk for fluid overload, but objective prediction tools to guide clinical decision-making lacking. The MRC-ICU scoring tool is an measuring medication regimen complexity. Objective: To evaluate the relationship between score and overload in critically patients. Methods: In this multi-center, retrospective, observational study, of was examined. Patient demographics, balance day 3 ICU admission, 24 hours, outcomes were collected from medical...
Abstract Background Identifying patterns within ICU medication regimens may help artificial intelligence algorithms to better predict patient outcomes; however, machine learning methods incorporating medications require further development, including standardized terminology. The Common Data Model for Intensive Care Unit (ICU) Medications (CDM-ICURx) provide important infrastructure clinicians and researchers support analysis of medication-related outcomes healthcare costs. Using an...
In this study, we introduce PharmacyGPT, a novel framework to assess the capabilities of large language models (LLMs) such as ChatGPT and GPT-4 in emulating role clinical pharmacists. Our methodology encompasses utilization LLMs generate comprehensible patient clusters, formulate medication plans, forecast outcomes. We conduct our investigation using real data acquired from intensive care unit (ICU) at University North Carolina Chapel Hill (UNC) Hospital. analysis offers valuable insights...
Abstract Fluid overload, while common in the ICU and associated with serious sequelae, is hard to predict may be influenced by medication use. Machine learning (ML) approaches offer advantages over traditional regression techniques it. We compared ability of different ML-based modeling identify clinically meaningful fluid overload predictors. This was a retrospective, observational cohort study adult patients admitted an ≥ 72 h between 10/1/2015 10/31/2020 available balance data. Models (a...
Abstract Objective Common data models provide a standard means of describing for artificial intelligence (AI) applications, but this process has never been undertaken medications used in the intensive care unit (ICU). We sought to develop common model (CDM) ICU standardize medication features needed support future AI efforts. Materials and Methods A 9-member, multi-professional team clinicians experts conducted 5-round modified Delphi employing conference calls, web-based communication,...
Introduction: Angiotensin II (Ang-2) is a non-catecholamine vasopressor that targets the renin-angiotensin-aldosterone system by agonism of angiotensin type 1 receptor. Its utility as and catecholamine-sparing agent was demonstrated in pivotal ATHOS-3 trial, numerous post-hoc analyses have shown reduced mortality certain subsets population. Methods: Consecutive adult patients at 5 centers who received Ang-2 from 2017-2020 were included this multicenter, retrospective observational cohort...
Abstract Background The MRC-ICU, a novel regimen complexity scoring tool, provides an objective measure of medication in critically ill patients. MRC-ICU may have the ability to evaluate impact critical care pharmacists on patient outcomes but requires further validation. this study was confirm external validity tool at multiple institutions and intensive unit (ICU) settings. Methods This multicenter, prospective, observational study. electronic medical record reviewed collect demographics...