A5059854039- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Anesthesia and Sedative Agents
- Traumatic Brain Injury and Neurovascular Disturbances
- Adrenal Hormones and Disorders
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Diversity and Career in Medicine
- Occupational and environmental lung diseases
- Innovations in Medical Education
- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antibiotics Pharmacokinetics and Efficacy
- Drug-Induced Adverse Reactions
- Dialysis and Renal Disease Management
- Liver Disease and Transplantation
University of Kentucky
2017-2024
University of Kentucky HealthCare
2017-2023
Mayo Clinic
2022
Mayo Clinic in Arizona
2022
Mayo Clinic Health System
2022
WinnMed
2022
American College of Clinical Pharmacy
2022
Albert B. Chandler Hospital
2020
Grady Health System
2018
Jacksonville University
2015
Background: This American Thoracic Society, European Respiratory Japanese and Asociación Latinoamericana de Tórax guideline updates prior idiopathic pulmonary fibrosis (IPF) guidelines addresses the progression of in patients with interstitial lung diseases (ILDs) other than IPF. Methods: A committee was composed multidisciplinary experts ILD, methodologists, patient representatives. 1) Update IPF: Radiological histopathological criteria for IPF were updated by consensus. Questions about...
We examined the association between fluid overload and major adverse kidney events in critically ill patients requiring continuous renal replacement therapy for acute injury.Retrospective cohort study.ICU a tertiary medical center.Four-hundred eighty-one adults injury.None.Fluid was assessed as balance from admission to initiation, adjusted body weight. Major were defined composite of mortality, therapy-dependence or inability recover 50% baseline estimated glomerular filtration rate (if not...
Abstract Objective Administration of diuretics has been shown to assist fluid management and improve clinical outcomes in the critically ill post-shock resolution. Current guidelines have not yet included standardization or guidance for diuretic-based de-resuscitation patients. This study aimed evaluate impact a multi-disciplinary protocol diuresis-guided ill. Methods was pre-post single-center pilot within medical intensive care unit (ICU) large academic center. Adult patients admitted...
Although the potential dangers of hyperchloremia from resuscitation fluids continue to emerge, no study date has considered contribution medication diluents cumulative volume and hyperchloremia. This compares saline versus dextrose 5% in water as primary diluent occurrence critically ill patients.Prospective, open-label, sequential period pilot study.Medical ICU a large academic medical center.Adult patients admitted were eligible for inclusion. Patients who less than 48 hours, 18 years old,...
Vasopressors such as norepinephrine are first line for support of mean arterial pressure (MAP) in the management septic shock. Their use, however, is commonly associated with many adverse events. These detriments frequently trigger use alternative, noncatecholamine therapies, including vasopressin. Vasopressin deficiency a known physiologic consequence shock, and while guidelines recommend vasopressin addition to norepinephrine, no consensus exists on duration or ideal time cessation....
Vancomycin is a first-line antibiotic for empiric treatment of gram-positive infections in the trauma intensive care unit. When dosed intermittently, difficulties arise from trough collection and drug monitoring. The objective this study was to evaluate time goal vancomycin levels comparing continuous infusion protocol when compared standard intermittent dosing. This retrospective cohort patients admitted unit between July 2011 2015 receiving at least 48 hours. In 150 patients, had decreased...
Background Fluid management during continuous renal replacement therapy (CRRT) requires accuracy in the prescription of desired patient fluid balance (FB Goal ) and precision attainable Achieved ). Herein, we examined association gap between prescribed vs. achieved CRRT (%FB Gap with hospital mortality critically ill patients. Methods Cohort study adults acute kidney injury (AKI) requiring a negative (mean goal ≥0.5 liters per day). parameters included: 1) NUF (net ultrafiltration rate); 2)...
Extracorporeal membrane oxygenation (ECMO) is a potential option for the management of severe acute respiratory failure secondary to COVID-19. Conflicting use this therapy known coagulopathy within COVID-19, leading an incidence venous thrombotic events 25% 49%. To date, limited guidance available on optimal anticoagulation strategies in population.The purpose study was evaluate utilization pharmacist-driven bivalirudin dosing protocol setting ECMO COVID-19-associated failure.This...