A5010458440- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Ultrasound and Hyperthermia Applications
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- MRI in cancer diagnosis
- Abdominal vascular conditions and treatments
- Photoacoustic and Ultrasonic Imaging
- Neuroendocrine Tumor Research Advances
- Medical Imaging Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound Imaging and Elastography
- Pancreatitis Pathology and Treatment
- Renal cell carcinoma treatment
- Amoebic Infections and Treatments
- Alcohol Consumption and Health Effects
- Atomic and Subatomic Physics Research
- Congenital Anomalies and Fetal Surgery
University Hospital of Geneva
2014-2023
University of Geneva
2013-2022
European Organisation for Research and Treatment of Cancer
2022
Hôpital Beau-Séjour
2008-2019
Massachusetts General Hospital
2016
Creative Research Enterprises (United States)
2016
Geneva College
2003-2015
Pancreas Centre (Canada)
2015
Nagoya University
2014
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2014
Transcatheter arterial chemoembolization (TACE) offers a survival benefit to patients with intermediate hepatocellular carcinoma (HCC). A widely accepted TACE regimen includes administration of doxorubicin-oil emulsion followed by gelatine sponge—conventional TACE. Recently, drug-eluting bead (DC Bead®) has been developed enhance tumor drug delivery and reduce systemic availability. This randomized trial compares conventional (cTACE) DC Bead for the treatment cirrhotic HCC. Two hundred...
In patients with synchronous colorectal liver metastases, an approach reversing the traditional therapeutic order - i.e. starting chemotherapy first, doing surgery second, and performing last is theoretically appealing as it avoids risk of metastatic progression during treatment primary tumor. The present series updates on a previously reported pilot experience.35 advanced metastases nonobstructive tumors were treated reversed approach. Data collected in prospective database.The median...
Objective Impaired liver regeneration is associated with a poor outcome in patients decompensated alcoholic disease (ALD). We assessed whether autologous bone marrow mononuclear cell transplantation (BMMCT) improved function ALD. Design 58 (mean age 54 yrs; mean MELD score 19, all cirrhosis, 81% steatohepatitis at baseline biopsy) were randomized early after hospital admission to standard medical therapy (SMT) alone (n = 30), including steroids Maddrey’s ≥32, or combined G-CSF injections and...
How Reliable Is Sonography in the Assessment of Sialolithiasis?Sylvain Terraz1, Pierre Alexandre Poletti1, Pavel Dulguerov2, Natalia Dfouni3, Christoph D. Becker1, Francis Marchal2 and Minerva Becker1Audio Available | Share
Bilobar colorectal metastases are a therapeutic challenge and require multidisciplinary approach. The aim of this study was to describe the clinical histological outcomes patients having neoadjuvant chemotherapy two-step hepatectomy with right portal vein occlusion for advanced bilateral metastases.A series 23 consecutive treated curative intent according standardized management protocol reviewed.Of patients, 22 completed programme. There no mortality Clavien grade III morbidity. Median...
Proton resonance frequency shift (PRFS) MR thermometry (MRT) is the generally preferred method for monitoring thermal ablation, typically implemented with gradient-echo (GRE) sequences. Standard PRFS MRT based on subtraction of a temporal reference phase map and is, therefore, intrinsically sensitive to tissue motion (including deformation) external perturbation magnetic field. Reference-free (or reference-less) has been previously described by Rieke was 2-D polynomial fit performed data...
C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy (1H MRS), we have repeatedly observed an abnormal neurochemical profile brains both wild-type and genetically modified derived from C57BL/6J strain, consisting a several fold increase cerebral glutamine two decrease myo-inositol. This strikingly "phenotype" resembles that chronic liver disease or portosystemic shunting appeared to be independent transgene, origin chow was not...
Purpose To determine whether quantification of liver surface nodularity (LSN) provides an estimate the presence clinically significant portal hypertension (CSPH) in patients with cirrhosis. Materials and Methods This retrospective study included a training cohort (n = 189) separate external validation 78), both composed cirrhosis who underwent abdominal CT hepatic venous pressure gradient (HVPG) measurement between 2010 2016. The LSN score, spleen volumes, liver-to-spleen volume ratio,...
The combination of ultrasound (US) and magnetic resonance imaging (MRI) may provide a complementary description the investigated anatomy, together with improved guidance assessment image-guided therapies. aim present study was to integrate clinical setup for simultaneous US (MR) acquisition obtain synchronized monitoring liver motion. feasibility this hybrid precision image fusion were evaluated.Ultrasound achieved using scanner modified be MR compatible, whereas MRI on 1.5- 3-T scanners....
Abstract MR acoustic radiation force imaging (ARFI) is an elegant adjunct to MR‐guided high intensity focused ultrasound for treatment planning and optimization, permitting in situ assessment of the focusing targeting quality. The thermal effect pulses associated with ARFI measurements recommended be monitored on line, particular when beam crosses highly absorbent structures or interfaces (e.g., bones air‐filled cavities). A dedicated sequence proposed here, derived from a segmented gradient...
Porto-sinusoidal vascular disorder (PSVD) is a rare and commonly overlooked cause of portal hypertension. The interest CT analysis, including quantification liver surface nodularity (LSN) for PSVD diagnosis has not been established. This study aimed at assessing the performance LSN features in patients with signs hypertension.This retrospective case-control included learning cohort consisting 50 histologically proven PSVD, according to VALDIG criteria, 100 control cirrhosis, matched on...
Positron Emission Tomography (PET) using (18)F-fluorodeoxyglucose (FDG) associated with computed tomography (CT) is increasingly used for the detection and staging of pancreatic cancer, but data regarding its clinical added value in pre-surgical planning still lacking. The aim this study to investigate performance FDG PET contrast-enhanced CT cancer.We prospectively evaluated PET/CT studies obtained patients suspicion operable cancer between May 2006 January 2008. Staging was conducted...
MR thermometry based on the proton resonance frequency shift (PRFS) is most commonly used method for monitoring of thermal therapies. As chemical water protons temperature dependent, local variation (relative to an initial baseline) may be calculated from time-dependent phase changes in gradient-echo (GRE) images. Dynamic GRE images also produced by magnetic bulk susceptibility tissue. Gas bubbles (known as "white cavitation") are frequently visualized near RF electrode...
Objective . To demonstrate the technical feasibility and potential interest of using a digital optical camera inside MR magnet bore for monitoring breathing cycle subsequently gating PRFS thermometry, MR-ARFI measurement, MRgHIFU sonication in upper abdomen. Materials Methods A was reengineered to remove its magnetic parts further equipped with 7 m long USB cable. The system electromagnetically shielded operated closed 3T clinical scanner. Suitable triggers were generated based on real-time...