A5032087488- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Sulfur Compounds in Biology
- Cardiovascular Disease and Adiposity
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Cardiac Ischemia and Reperfusion
- Heart rate and cardiovascular health
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Blood Pressure and Hypertension Studies
- Cardiac Fibrosis and Remodeling
- Genomics, phytochemicals, and oxidative stress
- Obstructive Sleep Apnea Research
- Cardiac pacing and defibrillation studies
- Cardiac tumors and thrombi
- Anesthesia and Neurotoxicity Research
- Angiogenesis and VEGF in Cancer
- Fungal and yeast genetics research
- Sulfur-Based Synthesis Techniques
Cedars-Sinai Medical Center
2022-2024
Harvard University
2023
Pondicherry University
2023
Institute of Genomics and Integrative Biology
2023
L'Oreal (United States)
2023
Johns Hopkins University
2014-2022
Johns Hopkins Medicine
2014-2022
East Sussex Healthcare NHS Trust
2022
Cedars-Sinai Smidt Heart Institute
2022
Louisiana State University Health Sciences Center New Orleans
2015-2019
Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation patients having heart failure heralds worse overall prognosis. In animal studies, or TMAO significantly accelerates atherosclerotic lesion development ApoE-deficient mice, reduction levels inhibits atherosclerosis low-density lipoprotein receptor knockout mouse.C57BL6/J mice were fed either control diet, diet containing (1.2%)...
Diagnosis of heart failure with preserved ejection fraction (HFpEF) among dyspneic patients without overt congestion is challenging. Multiple diagnostic approaches have been proposed but are not well validated against the independent gold standard for HFpEF diagnosis an elevated pulmonary capillary wedge pressure (PCWP) during exercise.To evaluate H2FPEF and HFA-PEFF scores a PCWP/cardiac output (CO) slope more than 2 mm Hg/L/min to diagnose HFpEF.This retrospective case-control study...
The epigenetic remodeling of chromatin histone proteins by acetylation has been the subject recent investigations searching for biomarkers indicative late onset cognitive loss. Histone acetylations affect regulation gene transcription, and loss learning induced deacetylation at specific sites may represent memory Alzheimer's disease (AD). Selected-reaction-monitoring (SRM) recently advanced to quantitate peptides in complex biological systems. In this paper, we provide evidence that...
Abstract A strategy to deliver a well‐defined persulfide species in biological medium is described. Under near physiological conditions, the prodrug can be activated by an esterase generate “hydroxymethyl persulfide” intermediate, which rapidly collapses form defined persulfide. Such prodrugs used either as chemical tools study chemistry and biology or for future development H 2 S‐based therapeutic reagents. Using developed this study, reactivity between S ‐methyl methanethiosulfonate (MMTS)...
There is a paucity of data about the mechanisms by which sacubitril/valsartan (also known as LCZ696) improves outcomes in patients with heart failure. Specifically, effects on vascular function and NO bioavailability have not been investigated. We hypothesized that therapy increases circulating levels setting failure.Male spontaneously hypertensive rats underwent myocardial ischemia/reperfusion surgery to induce failure were followed for up 12 weeks serial echocardiography. Rats received (68...
We describe the complete synthesis, assembly, debugging, and characterization of a synthetic 404,963 bp chromosome,
Catheter-based renal denervation (RDN) is currently under development for the treatment of resistant hypertension and thought to reduce blood pressure via interruption sympathetic pathways that modulate cardiovascular function. The nervous system also plays a critical role in pathogenesis acute myocardial infarction heart failure.We examined whether with radiofrequency (RF)-RDN would protect against subsequent ischemia/reperfusion injury direct effects on myocardium.Spontaneously...
Cardioprotective effects of H2S have been well documented. However, the lack evidence supporting benefits afforded by delayed therapy warrants further investigation. Using a murine model transverse aortic constriction-induced heart failure, this study showed that protects multiple organs including heart, kidney, and blood-vessel; reduces oxidative stress; attenuates renal sympathetic renin-angiotensin-aldosterone system pathological activation; ultimately improves exercise capacity. These...
Abstract A strategy to deliver a well‐defined persulfide species in biological medium is described. Under near physiological conditions, the prodrug can be activated by an esterase generate “hydroxymethyl persulfide” intermediate, which rapidly collapses form defined persulfide. Such prodrugs used either as chemical tools study chemistry and biology or for future development H 2 S‐based therapeutic reagents. Using developed this study, reactivity between S ‐methyl methanethiosulfonate (MMTS)...
Case Presentation: A 27-year-old female with a history of Crohn’s disease and prior pulmonary nocardiosis presented fever unknown origin (FUO) lung infiltrate. CT angiogram revealed segmental embolism sessile mass mobile components in the right atrium (RA). band-like extending from interventricular septum to body ventricle (RV) was also noted. Transthoracic echocardiogram confirmed these findings showed moderate severe tricuspid regurgitation. Lab testing notable for white blood cell count...
Rationale: Trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine, is elevated circulation patients at increased risk for heart attack and adverse prognosis during failure. Objective: We investigated effects choline TMAO on severity failure following transverse aortic constriction (TAC). Methods Results: Male C57Blk/6J mice were fed either control diet, diet containing (1.2%) or (0.12%) 3 weeks prior to surgical TAC studied 12 weeks. Left...