A5043660253- Sulfur Compounds in Biology
- Mitochondrial Function and Pathology
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
- Eicosanoids and Hypertension Pharmacology
- ATP Synthase and ATPases Research
- Hydrogen's biological and therapeutic effects
- Adipose Tissue and Metabolism
- Alcohol Consumption and Health Effects
- Osteoarthritis Treatment and Mechanisms
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Urinary Bladder and Prostate Research
- Sexual function and dysfunction studies
- Cardiovascular Disease and Adiposity
- Metabolism and Genetic Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Redox biology and oxidative stress
- Neurological Disorders and Treatments
- Muscle metabolism and nutrition
- Heme Oxygenase-1 and Carbon Monoxide
- Obstructive Sleep Apnea Research
- Neurological Disease Mechanisms and Treatments
- interferon and immune responses
- Renin-Angiotensin System Studies
Institut Pasteur
2021-2023
Centre National de la Recherche Scientifique
2021-2023
Université Paris Cité
2022-2023
Louisiana State University Health Sciences Center New Orleans
2015-2019
University of Naples Federico II
2013-2016
Zofenopril, a sulfhydrylated angiotensin-converting enzyme inhibitor (ACEI), reduces mortality and morbidity in infarcted patients to greater extent than do other ACEIs. Zofenopril is unique ACEI that has been shown increase hydrogen sulfide (H2S) bioavailability nitric oxide (NO) levels via bradykinin-dependent signaling. Both H2S NO exert cytoprotective antioxidant effects. We examined zofenopril effects on cardiac damage murine swine models of myocardial ischemia/reperfusion (I/R)...
Background Cystathionine γ‐lyase, cystathionine β‐synthase, and 3‐mercaptopyruvate sulfurtransferase are endogenous enzymatic sources of hydrogen sulfide (H 2 S). Functions H S mediated by several targets including ion channels signaling proteins. Nuclear factor‐erythroid 2‐related factor is responsible for the expression antioxidant response element–regulated genes known to be upregulated S. We examined levels S, S‐producing enzymes, nuclear activation status in skeletal muscle obtained...
Abstract Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is an inner mitochondrial membrane (IMM) protein dispensable for division yet essential cardiac structure function. Constitutive knockout cardiomyocyte MTFP1 in mice resulted a fatal, adult-onset dilated cardiomyopathy accompanied by extensive remodeling during transition heart failure. Prior onset disease, mitochondria displayed specific IMM...
Abstract Hepatic steatosis is the result of imbalanced nutrient delivery and metabolism in liver first hallmark Metabolic dysfunction-associated steatotic disease (MASLD). MASLD most common chronic involves accumulation excess lipids hepatocytes, inflammation, cancer. Mitochondria play central roles yet specific mitochondrial functions causally linked to remain unclear. Here, we identify Mitochondrial Fission Process 1 protein (MTFP1) as a key regulator metabolic activity liver. Deletion...
Background Bioavailability of nitric oxide ( NO ) and hydrogen sulfide (H 2 S) is reduced in heart failure HF ). Recent studies suggest cross‐talk between H S signaling. We previously reported that sodium nitrite (Na ameliorates myocardial ischemia‐reperfusion injury HF. Nuclear factor‐erythroid‐2‐related factor (Nrf2) regulates the antioxidant proteins expression upregulated by S. examined Na effects on endogenous bioavailability Nrf2 activation mice subjected to ischemia‐induced chronic...
Abstract The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H 2 S as possible mediator released downstream following muscarinic (M) activation, by using human bladder and urothelial T24 cell line. Carbachol stimulation enhances production in turn cGMP or cells. This effect is reversed cysthationine-β-synthase (CBS) inhibition. blockade M1 M3 receptors reverses increase urothelium. In...
Endogenously produced hydrogen sulfide (H2S) is critical for cardiovascular homeostasis. Therapeutic strategies aimed at increasing H2S levels have proven cardioprotective in models of acute myocardial infarction (MI) and heart failure (HF). The present study was undertaken to investigate the effects a novel prodrug, SG-1002, on stress induced hypertrophic signaling murine HL-1 cardiac muscle cells. Treatment cells with SG-1002 under serum starvation without or H2O2 increased H2S, producing...
Abstract CHCHD10 is an amyotrophic lateral sclerosis/frontotemporal dementia gene that encodes a mitochondrial protein whose precise function unclear. Here we show Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10 interacts with the Stomatin-Like Protein 2 and participates in stability of prohibitin complex inner membrane. By using patient fibroblasts mouse models expressing same variant (p.Ser59Leu), forms aggregates prohibitins, found vivo hippocampus as aggresome-like inclusions...
Metabolic syndrome (MetS) reduces endothelial nitric oxide (NO) bioavailability and exacerbates vascular dysfunction in patients with preexisting diseases. Nitrite, a storage form of NO, can mediate function during pathological conditions when endogenous NO is reduced. The aims the present study were to characterize effects severe MetS obesity on dyslipidemia, myocardial oxidative stress, synthase (eNOS) regulation obese Ossabaw swine (OS) model examine novel, sustained-release formulation...
Adult cardiomyocytes are embedded within a highly organized myocardial microenvironment that imposes critical geometric cues es- sential for the alignment and distribution of organelles shaping their unique, rectangular cellular morphology. Despite association cardiomyocyte disarray with human heart disease, functional consequences this disorganization remain poorly understood. Here, we leveraged micropatterned substrates to promote structural in induced pluripotent stem cell-derived...
Urotensin-II (U-II) is a cyclic peptide that acts through G protein-coupled receptor (urotensin-II [UTR]) mainly involved in cardiovascular function humans. The urotensinergic system also implicated the urogenital tract. Indeed, U-II relaxes human corpus cavernosum strips and causes an increase intracavernous pressure (ICP) rats. In light of this, U-II/UTR pathway can be considered new target for treatment erectile dysfunction. On this hypothesis, herein we report on two UTR high...
Background: Nitric oxide (NO) and hydrogen sulfide (H 2 S) are reduced in congestive heart failure. Recent studies suggest cross-talk between NO H S signaling. We previously reported that sodium nitrite (NaNO ) significantly ameliorates myocardial ischemia-reperfusion injury Nrf2 regulates the expression of antioxidant protein genes is upregulated by S. examined effects NaNO therapy on endogenous bioavailability activation mice subjected to ischemia-induced Materials Methods: Mice underwent...
Abstract Hepatic steatosis is the result of an imbalance between nutrient delivery and metabolism in liver. It first hallmark Non-alcoholic fatty liver disease (NAFLD) characterized by accumulation excess lipids that can drive failure, inflammation, cancer. Mitochondria control fate function cells compelling evidence implicates these multifunctional organelles appearance progression dysfunction, although it remains to be elucidated which specific mitochondrial functions are actually causally...
Abstract Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is essential for cardiac structure function. Constitutive knockout cardiomyocyte MTFP1 in mice resulted adult-onset dilated cardiomyopathy (DCM) characterized by sterile inflammation fibrosis progressed heart failure middle-aged death. Failing hearts from cardiomyocyte-restricted displayed a general decline mitochondrial gene expression oxidative...
Introduction: Glucocorticoid (GC) excess is related to hypertension. The deletion of endothelial GC-receptors abrogates the blood pressure increase, suggesting GC-induced hypertension endothelium-dependent. In response shear stress endothelium releases nitric oxide, derived hyperpolarizing factor (EDHF) and prostacyclin. Recently H2S has been proposed as a candidate for EDHF. mainly produced by enzymes cystathionine β-synthase (CBS) γ-lyase (CSE) from L-cysteine. aim this study was...
Background: Cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) are enzymatic sources of hydrogen sulfide (H2S). Functions H2S mediated by several targets including ion channels signaling proteins. Nuclear factor-erythriod 2-related factor 2 (NRF2) is responsible for the expression antioxidant response element (ARE)-regulated genes known to be upregulated H2S. We examined levels producing enzymes, H2S, NRF2 activation status in...