A5009417120- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Complement system in diseases
- Ion Transport and Channel Regulation
- Muscle and Compartmental Disorders
- Renal function and acid-base balance
- Eosinophilic Disorders and Syndromes
- Dialysis and Renal Disease Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Kidney Disease and Diabetes
- Drug-Induced Hepatotoxicity and Protection
- Renal cell carcinoma treatment
- Electrolyte and hormonal disorders
- Nephrotoxicity and Medicinal Plants
- Cancer Immunotherapy and Biomarkers
- Vasculitis and related conditions
- Thyroid Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Multiple and Secondary Primary Cancers
- Potassium and Related Disorders
- Drug-Induced Adverse Reactions
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
Université de Caen Normandie
2022-2024
Centre Hospitalier Universitaire de Caen
2022-2024
Normandie Université
2024
Pitié-Salpêtrière Hospital
2011-2021
Sorbonne Université
2011-2021
Association pour l'Utilisation du Rein Artificiel
2015-2021
Assistance Publique – Hôpitaux de Paris
2012-2019
Laboratoire d'études sur les monothéismes
2014
Délégation Paris 6
2014
Centre de Recherche des Cordeliers
2013
Expanded clinical experience with patients taking antiangiogenic compounds has come increasing recognition of the renal adverse effects. Because histology is rarely sought in those patients, consequences are underestimated. Antiangiogenic-treated-cancer who had a biopsy for effects from 2006 to 2013, were included current study. Clinical features and histologic findings reviewed. Our cohort was 100 (58 women) biopsy-proven kidney disease using anti-vascular endothelial growth factor (VEGF)...
Inactivation of the B1 proton pump subunit (ATP6V1B1) in intercalated cells (ICs) leads to type I distal renal tubular acidosis (dRTA), a disease associated with salt- and potassium-losing nephropathy. Here we show that mice deficient ATP6V1B1 (Atp6v1b1-/- mice) displayed loss NaCl, K+, water, causing hypovolemia, hypokalemia, polyuria. We demonstrated NaCl originated from cortical collecting duct, where activity both epithelial sodium channel (ENaC) pendrin/Na(+)-driven chloride/bicarbonate...
Avacopan, a selective C5aR1 inhibitor, recently emerged as glucocorticoid (GCs) sparing agent in ANCA-associated vasculitis (AAV). We aim to evaluate the tolerance and efficacy of avacopan given outside randomized clinical trials or with severe kidney involvement.
Secondary hyperparathyroidism (SHPT) is frequent in haemodialysis (HD) patients. Oral cinacalcet-hydrochloride (HCl) decreases parathyroid hormone (PTH); however, real-life PTH data, according to Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, are still lacking. Our goal assess the percentage of cinacalcet-HCl-treated HD patients with controlled SHPT (PTH <9× upper limit normal range) after 12 months (M12) treatment.This a retrospective observational study treated by...
The hypereosinophilic syndromes (HESs) are a group of disorders marked by the sustained overproduction eosinophils, in which eosinophilic infiltration and mediator release cause damage to multiple organs. In idiopathic HES, underlying hypereosinophilia (HE) remains unknown despite thorough aetiological work-up. Kidney disease is thought be rare HES. Renal manifestations described include interstitial nephritis, various types glomerulopathies, thrombotic microangiopathy (TMA) electrolyte...
Malaria, a potentially life-threatening disease, is the most prevalent endemic infectious disease worldwide. In modern era, spectrum of glomerular involvement observed in patients after malarial infections remains poorly described.We therefore performed retrospective multicenter study to assess clinical, biologic, pathologic, and therapeutic characteristics with demonstrated by kidney biopsy France within 3 months an acute malaria episode.We identified 23 (12 men), all but 1 African ancestry...
Onconephrology is a growing discipline that aims to improve the management of patients with cancer and kidney disease. If histology an essential key, anatomopathological data remain weak although this complex management. Patients active who had biopsy (KB) between 2014 2020 were included, their clinicobiological histological analyzed retrospectively. Our cohort consisted 154 (83 women) mean age 58 years. One hundred twelve presented proteinuria, 95 acute injury, 59 arterial hypertension....
Nonhematologic malignancies are rarely reported to be associated with AA amyloidosis. Although the association between renal cell carcinoma and systemic amyloidosis has been established, evidence linking pulmonary cancer is scarce. Here, a case of biopsy-proven complicated nephrotic syndrome lung reported.
Gueutin V, Ficheux M, Châtelet Lecouf A, Henri P, Hurault de Ligny B, Ryckelynck J-P, Lobbedez T. Hydration status of patients with end-stage renal disease after kidney transplantation. Clin Transplant 2011: 25: E656–E663. © 2011 John Wiley & Sons A/S. Abstract: Background: This study was carried out to estimate the modification hydration within first three months Subjects and methods: Fifty who underwent a allograft were prospectively followed for transplantation assess by bioimpedance...
Background: Thrombotic microangiopathies (TMAs) can be induced by drugs. Recent works have indicated proteasome inhibitors, including carfilzomib, as a possible new causative agent. Although the physiopathology and management of carfilzomib-induced TMA are still unknown, eculizumab seems to efficient. Results: We report clinical case during carfilzomib treatment for multiple myeloma, possibly triggered concomitant influenza infection, suggesting multi-hit process. Histologic analysis kidney...
The approval of febuxostat, a non-purine analogue inhibitor xanthine oxidase, by the European Medicines Agency and US Food Drug Administration, heralds new era in treatment gout [1]. most commonly reported adverse drug reactions were liver function abnormalities, diarrhoea, headache, nausea, dizziness and/or altered taste. Only one case cutaneous leukocytoclastic vasculitis has been with febuxostat [2]. In this report, we provide first anti-neutrophil cytoplasmic antibody (ANCA)-positive...
We report a case of renal thrombotic microangiopathy (TMA) in myeloproliferative variant hypereosinophilic syndrome (HES) 24-year-old man which resolved with imatinib therapy. This is one few cases the literature to date describing TMA HES, suggesting that pathogenesis thrombosis at least part related damage from activated eosinophils.
The anti-neutrophil cytoplasmic antibody (ANCA) renal risk score (ARRS) for predicting survival in ANCA-associated vasculitis (AAV) had not previously been validated adults over 65 years of age and presenting impairments associated with an aging kidney, a high cardiovascular comorbidity burden prevalent microscopic polyangiitis.