A5105510448- Acute Kidney Injury Research
- Methemoglobinemia and Tumor Lysis Syndrome
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Respiratory Support and Mechanisms
- Muscle and Compartmental Disorders
- Cardiac Arrest and Resuscitation
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Poisoning and overdose treatments
- Abdominal vascular conditions and treatments
- Aortic aneurysm repair treatments
- Electrolyte and hormonal disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Complement system in diseases
- Legionella and Acanthamoeba research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Radiology practices and education
- Chronic Kidney Disease and Diabetes
- Infectious Diseases and Tuberculosis
- Potassium and Related Disorders
- Amoebic Infections and Treatments
- Ultrasound in Clinical Applications
- Glioma Diagnosis and Treatment
- Alcoholism and Thiamine Deficiency
Assistance Publique – Hôpitaux de Paris
2013-2025
Sorbonne Université
2021-2025
Hôpital Tenon
2021-2025
Metabolism and Renal Physiology
2007-2022
Hôpital Louis-Mourier
2013-2016
Délégation Paris 7
2013-2014
Sorbonne Paris Cité
2013-2014
Université Paris Cité
2013-2014
Délégation Paris 5
2014
Hôpital Européen Georges-Pompidou
2014
Tracheal intubation of ICU patients is frequently associated with severe hypoxemia. Although noninvasive ventilation reduces desaturation during severely hypoxemic patients, it does not allow for per-procedure oxygenation and has been evaluated in mild-to-moderate whom high-flow nasal cannula oxygen may be an alternative. We sought to compare pre- either a nonrebreathing bag reservoir facemask or tracheal patients.Prospective quasi-experimental before-after study (ClinicalTrials.gov:...
The prognosis for kidney survival is poor in patients presenting with circulating anti-glomerular basement membrane (GBM) antibodies and severe injury. It unknown if treatment an endopeptidase that cleaves bound IgG can alter the prognosis.An investigator-driven phase 2a one-arm study (EudraCT 2016-004082-39) was performed 17 hospitals five European countries. A single dose of 0.25 mg/kg imlifidase given to 15 adults anti-GBM eGFR <15 ml/min per 1.73m2. All received standard cyclophosphamide...
Excessive correction of chronic and profound hyponatremia may result in central pontine myelinolysis cause permanent brain damage. In the case foreseeable or established overcorrection, slowing down rate sodium plasma levels (PNa) reinducing mild prevent this neurologic complication.This retrospective observational study was performed with 20 consecutive patients admitted to two intensive care units for severe hyponatremia, defined by PNa <120 mmol/L and/or complications ascribable...
Patients with pheochromocytoma (PH) or paraganglioma (PGL) may suffer from tumor persistence recurrence after resection of the primary tumor. Malignancy and genetic determinants account for vast majority these cases, but also arise spillage during resection, followed by peritoneal implantation. We report here five such cases.Thirty-nine 181 patients referred to our unit a PH experienced as result malignant disease (n = 12), new PGL in context 18) incomplete surgical 4). Another presenting...
Noninvasive ventilation (NIV) requires a close "partnership" between conscious patient and the patient's caregivers. Specific perceptions of NIV stakeholders their impact have been poorly described to date. The objectives this study were compare by intensive care unit (ICU) physicians, nurses, patients, relatives explore factors associated with caregivers' willingness administer patients' relatives' anxiety in relation NIV.This is prospective, multicenter questionnaire-based study.Three...
Malaria, a potentially life-threatening disease, is the most prevalent endemic infectious disease worldwide. In modern era, spectrum of glomerular involvement observed in patients after malarial infections remains poorly described.We therefore performed retrospective multicenter study to assess clinical, biologic, pathologic, and therapeutic characteristics with demonstrated by kidney biopsy France within 3 months an acute malaria episode.We identified 23 (12 men), all but 1 African ancestry...
To evaluate the diagnostic performances of two training programs for residents with no prior ultrasound experience to reach competences in extended basic critical care transthoracic echocardiography (CCE) including Doppler capabilities.This is a prospective observational study intensive units teaching hospitals. Group I (five residents) completed short program (4-h theory; 3-h practical); group II (six longer (6-h 12-h practical). The and an expert examined all patients who required...
Genomic information has the potential to reshape management of Thrombotic microangiopathy (TMA) which encompasses in 10% cases various genetically-related diseases, with some them could benefit specific therapy that should be initiated as soon possible (Complement C5 blocking, VitB12 therapy). Yet, structural variants (SV) affecting CFH/CFHR gene region, lead fusions, despite constituting less than 5% complement dependent TMA (c-TMA) represents a molecular diagnostic bottleneck large impact...
<b><i>Introduction:</i></b> Hypertensive nephrosclerosis (HN) ranks as one of the most frequent causes chronic kidney disease (CKD), but its very existence has repeatedly been called into question, especially in young adults. Its diagnostic framework is established chiefly on non-specific clinical criteria, and defining histopathological set features fact shared by numerous other conditions. Genetic testing based exome sequencing (ES) emerged a comprehensive tool to...