A5051772252- Renal cell carcinoma treatment
- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Metabolism and Genetic Disorders
- Acute Kidney Injury Research
- Diet and metabolism studies
- Renal and Vascular Pathologies
- Lysosomal Storage Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Neonatal Health and Biochemistry
- Alkaline Phosphatase Research Studies
- Renal function and acid-base balance
- Chronic Lymphocytic Leukemia Research
- Selenium in Biological Systems
- Biochemical effects in animals
- Birth, Development, and Health
- Drug-Induced Ocular Toxicity
- Mitochondrial Function and Pathology
- Bone and Joint Diseases
- Peroxisome Proliferator-Activated Receptors
- Methemoglobinemia and Tumor Lysis Syndrome
- Hemoglobinopathies and Related Disorders
- Heterotopic Ossification and Related Conditions
Assistance Publique – Hôpitaux de Paris
2017-2024
Hôpital Tenon
2018-2024
Sorbonne Université
2018-2024
Inserm
2022-2024
Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée
2023
Hôpital Saint-Louis
2022
Hôpital Bichat-Claude-Bernard
2017
Sorbonne Paris Cité
2017
Université Paris Cité
2017
Délégation Paris 7
2017
Abstract Background In the context of tumor lysis syndrome (TLS), optimal timing and criteria for initiating kidney replacement therapy (KRT) remain unclear. This study aims to assess effect KRT at various phosphatemia thresholds on Major Adverse Kidney Events day 30 (MAKE30). Methods results We retrospectively emulated a pragmatic clinical trial comparing initiation versus conventional approach during TLS MAKE30. All consecutive patients admitted ICU Saint-Louis University hospital in Paris...
Abstract Background Tumor lysis syndrome (TLS) is a life-threatening complication during the treatment of malignant neoplasia. We sought to describe characteristics and predictors acute kidney injury (AKI), remission mortality in high-risk TLS patients. In this retrospective monocentric study, we included all patients with diagnosis biological and/or clinical from 2012 2018. The primary outcome was prevalence AKI phase TLS. Secondary outcomes were overall underlying malignancy at 1 year....
ATP depletion is a hallmark of acute kidney injury. Proliferation instrumental to repair. We show that levels vary during the cell cycle and proliferation sensitizes renal epithelial cells superimposed injuries in vitro. More less energy production by mitochondria are associated with adverse outcomes injured allografts. This suggests controlling timing repair might be beneficial mitigate extent
Hydroxychloroquine (HCQ) is largely prescribed as an immunomodulator to prevent systemic diseases flares in patients with lupus erythematous, rheumatoid arthritis, Sjogren's disease. Among reported side effects, HCQ can accumulate lysosomes and induced phospholipidosis. Here, we report HCQ-induced podocytopathy mimicking Fabry disease (FD). They share the same histological lesions: cytoplasmic vacuolisation of podocytes zebra bodies on light electronic microscopy. FD has been ruled out by...
Focal segmental glomerulosclerosis (FSGS) is a major cause of end-stage renal disease and remains without specific treatment. To identify new events during FSGS progression, we used an experimental model associated with nephroangiosclerosis in rats injected L-NAME (Nω-nitro-L-arginine methyl ester). After transcriptomic analysis focused our study on the role Isthmin-1 (ISM1, anti-angiogenic protein involved endothelial cell apoptosis. We studied expression ISM1 other models proteinuria,...
<b><i>Introduction:</i></b> Hypertensive nephrosclerosis (HN) ranks as one of the most frequent causes chronic kidney disease (CKD), but its very existence has repeatedly been called into question, especially in young adults. Its diagnostic framework is established chiefly on non-specific clinical criteria, and defining histopathological set features fact shared by numerous other conditions. Genetic testing based exome sequencing (ES) emerged a comprehensive tool to...
Abstract Acute kidney injury (AKI) is a prevalent and significant complication in critically ill patients, its management remains considerable challenge. The highly metabolic organ, consuming producing substantial amounts of ATP, mainly through mitochondrial oxidative phosphorylation. Recently, dysfunction has been identified as key factor the pathophysiology AKI progression to chronic disease. complex comprising millions structural functional units. These nephrons are composed different...
Amanita phalloides-related kidney toxicity is poorly documented and remains to be elucidated. Herein, we describe the case of a 43-year old patient who presented with severe liver failure following ingestion phalloides. Although injury subsided administration N-acetyl cystein silibinin, subsequently developed KDIGO stage 3 acute injury. Histopathological examination displayed moderate tubular characterized by dilated lumens flattening epithelium on optic microscopy. Electron microscopy...
Journal Article Management of severe hypercalcaemia: results the French-speaking physicians’ practice survey Get access Cyril Mousseaux, Mousseaux Soins Intensifs de Néphrologie et Rein Aigu, Hôpital Tenon, AP-HP, Paris, FranceINSERM UMR_S1155, CoRaKID, FranceFaculté Médecine, Sorbonne Université, France Correspondence to: Mousseaux; E-mail: cyril.mousseaux@aphp.fr Search for other works by this author on: Oxford Academic PubMed Google Scholar Romain Arrestier, Arrestier Service Médecine...
<h3>Background</h3> Patients with chronic inflammatory rheumatic diseases (IRD) receiving immunosuppressive therapy are at high risk for invasive pneumococcal disease. Despite national recommendations regarding vaccination, vaccination rate remains low in this population. <h3>Objectives</h3> We aimed to determine whether a nurse-led program improve coverage among patients IRD. <h3>Methods</h3> From April August 2015, all consecutive adult IRD admitted our day hospital unit (Department of...
Abstract Background and Aims Mitochondrial dysfunction energy metabolism deficiency are part of the acute kidney injury (AKI) pathophysiology. In particular, recent studies highlighted role nicotinamide adenine dinucleotide (NAD) production in pathogenesis AKI. NAD is an electron carrier for mitochondria a cofactor cytoplasmic redox reactions. Its decreased during AKI following expression PGC1α (Peroxisome proliferator activated receptor gamma co-activator-1-α). inactivation worsened its...
Abstract BACKGROUND AND AIMS Hypertensive nephrosclerosis ranks as one of the most frequent causes chronic kidney disease (CKD) worldwide and is deemed to be especially prevalent among patients African ancestry [1]. The very existence hypertensive nephropathy has been called into question, in young adults. Its diagnostic framework based on non-specific clinical criteria, its histopathological features are fact unspecific. Genetic testing with exome sequencing (ES) emerged a comprehensive...